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| 1 | A novel quantified bitterness evaluation model for traditional Chinese herbs based on an animal ethology principle显示文摘Traditional Chinese herbs(TCH) are currently gaining attention in disease prevention and health care plans. However, their general bitter taste hinders their use. Despite the development of a variety of taste evaluation methods, it is still a major challenge to establish a quantitative detection technique that is objective, authentic and sensitive. Based on the two-bottle preference test(TBP), we proposed a novel quantitative strategy using a standardized animal test and a unified quantitative benchmark. To reduce the difference of results, the methodology of TBP was optimized. The relationship between the concentration of quinine and animal preference index(PI) was obtained. Then the PI of TCH was measured through TBP, and bitterness results were converted into a unified numerical system using the relationship of concentration and PI. To verify the authenticity and sensitivity of quantified results,human sensory testing and electronic tongue testing were applied. The quantified results showed a good discrimination ability. For example, the bitterness of Coptidis Rhizoma was equal to 0.0579 mg/mL quinine, and Nelumbinis Folium was equal to 0.0001 mg/mL. The validation results proved that the newassessment method for TCH was objective and reliable. In conclusion, this study provides an option for the quantification of bitterness and the evaluation of taste masking effects. | Xue Han Hong Jiang Li Han Xi Xiong Yanan He Chaomei Fu Runchun Xu Dingkun Zhang Junzhi Lin Ming Yang | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 17 |
| 2 | Energy metabolism disorders and potential therapeutic drugs in heart failure显示文摘Heart failure(HF)is a global public health problem with high morbidity and mortality.A large number of studies have shown that HF is caused by severe energy metabolism disorders,which result in an insufficient heart energy supply.This deficiency causes cardiac pump dysfunction and systemic energy metabolism failure,which determine the development of HF and recovery of heart.Current HF therapy acts by reducing heart rate and cardiac preload and afterload,treating the HF symptomatically or delaying development of the disease.Drugs aimed at cardiac energy metabolism have not yet been developed.In this review,we outline the main characteristics of cardiac energy metabolism in healthy hearts,changes in metabolism during HF,and related pathways and targets of energy metabolism.Finally,we discuss drugs that improve cardiac function via energy metabolism to provide new research ideas for the development and application of drugs for treating HF. | Yanan He Wei Huang Chen Zhang Lumeng Chen Runchun Xu Nan Li Fang Wang Li Han Ming Yang Dingkun Zhang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 11 |
| 3 | GPU-accelerated computing of three-dimensional solar wind background显示文摘High-performance computational models are required to make the real-time or faster than real-time numerical prediction of adverse space weather events and their influence on the geospace environment.The main objective in this article is to explore the application of programmable graphic processing units(GPUs)to the numerical space weather modeling for the study of solar wind background that is a crucial part in the numerical space weather modeling.GPU programming is realized for our Solar-Interplanetary-CESE MHD model(SIP-CESE MHD model)by numerically studying the solar corona/interplanetary solar wind.The global solar wind structures are obtained by the established GPU model with the magnetic field synoptic data as input.Meanwhile,the time-dependent solar surface boundary conditions derived from the method of characteristics and the mass flux limit are incorporated to couple the observation and the three-dimensional(3D)MHD model.The simulated evolution of the global structures for two Carrington rotations 2058 and 2062 is compared with solar observations and solar wind measurements from spacecraft near the Earth.The MHD model is also validated by comparison with the standard potential field source surface(PFSS)model.Comparisons show that the MHD results are in good overall agreement with coronal and interplanetary structures,including the size and distribution of coronal holes,the position and shape of the streamer belts,and the transition of the solar wind speeds and magnetic field polarities. | FENG XueShang ZHONG DingKun XIANG ChangQing ZHANG Yao | 2013 | Science China Earth Sciences2013，56，11： | 7 |
| 4 | Effect of SF6 on Ozone Generation Using Dielectric Barrier Discharge显示文摘The influence mechanism of a small amount of SF6 on ozone generation in oxygen or air discharge is investigated.Some results are obtained by probing into the number of the high-energy electrons,which have the sufficiency energy for generating ozone.Introducing a small amount of SF6 into oxygen sharply decreases the number of high-energy electrons,because the electron density decreases sharply while the mean electron energy remains constant due to higher breakdown voltage and lower discharge power,and some high-energy electrons are consumed by the excitation and attachment of SF6.In contrast,when a small amount of SF6 is added into dry air discharge,despite the consumption of the excitation and attachment of SF6,the number of high energy electrons increases sharply,which is attributed to the higher mean electron energy and electron density resulted from higher breakdown voltage and discharge power.When the volume fraction of SF6 increases from 0 to 2.22%,the ozone mass concentration and the ozone yield increase by 45.7% and 29.7%,respectively.Therefore,though the oxygen source should avoid the presence of SF6,adding a small amount of SF6 can improve the ozone mass concentration and the efficiency of ozone generation. | WEI Linsheng DONG Guopan ZHANG Yafang YUAN Dingkun HU Zhaoji FU Chunyi | 2013 | 高电压技术2013，39，10： | 2 |
| 5 | Security Defence Policy Selection Method Using the Incomplete Information Game Model显示文摘Nowadays, the network defence policy selection using game model of incomplete information ignores the type of the defender, which quantifies cost simply, resulting in unreasonable defence policies selection. Aiming at the problem, we use Bayesian game theory to model the active defence policy selection. We take the types of both the attacker and the defender into consideration. Besides, the traditional quantization method is enhanced. Then, we calculate the equilibrium of static Bayesian game. Based on the analysis of the equilibrium, we select the optimal defence policy through the prediction for attackers' actions. The paper calculates the defence effectiveness of defence policies and provides a defence policies selection algorithm. Ultimately, we present an example to verify the effectiveness of the method and model proposed in the paper. | ZHANG Hengwei YU Dingkun WANG Jindong HAN Jihong WANG Na | 2015 | China Communications2015，12，S2： | 1 |
| 6 | Two superoxide dismutase (SOD) with different subcellular localizations involved in innate immunity in Crassostrea hongkongensis显示文摘 | Ziniu Yu Xiaocui He Dingkun Fu Yang Zhang | 2011 | Fish and Shellfish Immunology2011，，4： | 1 |
| 7 | Coupling of Adhesion and Anti‑Freezing Properties in Hydrogel Electrolytes for Low‑Temperature Aqueous‑Based Hybrid Capacitors显示文摘Solid-state zinc-ion capacitors are emerging as promising candidates for large-scale energy storage owing to improved safety,mechanical and thermal stability and easy-to-direct stacking.Hydrogel electrolytes are appealing solid-state electrolytes because of eco-friendliness,high conductivity and intrinsic flexibility.However,the electrolyte/electrode interfacial contact and anti-freezing properties of current hydrogel electrolytes are still challenging for practical applications of zinc-ion capacitors.Here,we report a class of hydrogel electrolytes that couple high interfacial adhesion and anti-freezing performance.The synergy of tough hydrogel matrix and chemical anchorage enables a well-adhered interface between hydrogel electrolyte and electrode.Meanwhile,the cooperative solvation of ZnCl2 and LiCl hybrid salts renders the hydrogel electrolyte high ionic conductivity and mechanical elasticity simultaneously at low temperatures.More significantly,the Zn||carbon nanotubes hybrid capacitor based on this hydrogel electrolyte exhibits low-temperature capacitive performance,delivering high-energy density of 39 Wh kg^(-1)at-60°C with capacity retention of 98.7%over 10,000 cycles.With the benefits of the well-adhered electrolyte/electrode interface and the anti-freezing hydrogel electrolyte,the Zn/Li hybrid capacitor is able to accommodate dynamic deformations and function well under 1000 tension cycles even at-60°C.This work provides a powerful strategy for enabling stable operation of low-temperature zinc-ion capacitors. | Jingya Nan Yue Sun Fusheng Yang Yijing Zhang Yuxi Li Zihao Wang Chuchu Wang Dingkun Wang Fuxiang Chu Chunpeng Wang Tianyu Zhu Jianchun Jiang | 2024 | Nano-Micro Letters2024，16，2： | 0 |
| 8 | Study on aerosol agglomeration using the airborne ultrasonic transducer显示文摘Acoustic agglomeration technology use high-intensity acoustic field to make aerosol particles collide and condense rapidly. Existing studies have shown that 70%–90% of fine particles can be eliminated within minutes using compression drives and air-jet generators. Currently, there are limitations to the sound sources used. In this paper, an airborne ultrasonic transducer with a resonant frequency of 15 kHz is designed, followed by the corresponding numerical simulation and experiments for the evaluation of the vibration modal and sound pressure field. The sound pressure levels (SPL) of the open space and the agglomeration chamber can reach 150 dB and 156 dB, respectively. The agglomeration effect of water droplets, liquid phase smoke, solid phase smoke and mixed smoke is experimentally investigated, and the light transmittance rapidly increases from 8% to 60% within 4 s, 8 s, 5 s and 6 s, respectively. Agglomeration is also effective in the high-frequency range, and we infer that the acoustic wake effect is the predominant mechanism. The elimination effect is promoted with the increasing of SPL until the corresponding secondary acoustic effect is enhanced. Moreover, the agglomeration rate of higher concentration aerosol is significantly better than that of diluted aerosols in ultrasonic agglomeration process. | Yuxin Guo Guangxue Zhang Yunchao Li Hailin Gu Dingkun Yuan Maosheng Liu | 2023 | Particuology2023，，11： | 0 |
| 9 | Phyllanthi Fructus:A modal medicinal and food homologous item in quality evaluation显示文摘Phyllanthi Fructus is a highly unique medicine and food homologous item,which exhibits distinctive flavor,notable nutritional value,and abundant pharmacological activity.It has enormous potential in the creation of health products and pharmaceuticals.However,due to the unique laws of quality formation and transfer of Phyllanthi Fructus,its appearance,shape,chemical compositions,nutrients,and sensory flavors are frequently greatly influenced by botanical resources,the processing and storage conditions.As a result,the current quality evaluation model is difficult to meet the needs of Phyllanthi Fructus as a medicine and food homologous item in the development of diversified products.This paper constructs the hierarchical utilization mode of Phyllanthi Fructus based on its unique quality formation and transmission laws,explores the quality evaluation model for food-oriented use and medicinal-oriented use,respectively,and systematically describes the quality evaluation idea under diversified application scenarios.This paper aims to serve as a reference for the construction of a quality evaluation model suitable for the medicine and food homologous item of Phyllanthi Fructus. | Gefei Li Yurou Jiang Dingkun Zhang Li Han Taigang Mo Sanhu Fan Haozhou Huang Junzhi Lin | 2023 | Chinese Herbal Medicines2023，15，3： | 0 |
| 10 | Recent Development of Gas-Solid Phase Chemiluminescence显示文摘Serving as a classic and interesting strategy,gas–solid phase chemiluminescence(CL)has recently been a rapidly growing area where CL is emitted through chemical reactions between gas and solid reactants occurred on the surface of solid matter.This CL system provided a sensitive and simple spectral method for investigating gas–solid phase reactions while information on the rate constants,intermediate productions,surface states and reaction mechanisms of interaction could be acquired.Recent progresses mainly concentrate on development of new gas–solid phase CL systems and their practical applications.This review paper summarized main classifications,mechanisms and applications of gas–solid phase CL.The future prospects for gas–solid phase CL are discussed. | Dingkun Zhang Jin‑Ming Lin | 2017 | Journal of Analysis and Testing2017，1，4： | 0 |
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