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| 1 | Solutions for submucosal injection: What to choose and how to do it显示文摘During the past decades, endoscopic resection techniques have gradually improved and gained more importance for the management of premalignant lesions and early cancers. These endoscopic resection techniques can be divided in 3 major groups: snare polipectomy, endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD). The use of submucosal injection is essential for the majority of EMR techniques and is an integral part of ESD,whereas during polipectomy it is not crucial in most cases except to prevent bleeding in large polyps and/or those with large stalks as an alternative to mechanical methods. Injection provides a lifting up effect of the lesion separating it from the muscular layer, thereby reducing thermal injury and the risk of perforation and bleeding while also facilitating en-bloc resection by improving technical feasibility. With this work, we aim to review the most common endoscopic resection techniques and the importance of submucosal injection in each one of them. For that, we present some of the most commonly used submucosal injection solutions, taking into account their advantages and disadvantages. We also discuss, based on current recommendations and our own experience, how and when to preform submucosal injection, depending on lesions features and endoscopic resection technique that′s being used, to assure complete resection and to prevent associated adverse events. Finally, we also present and discuss some new proposed submucosal injection solutions,endoscopic resection techniques and devices that may have a major impact on the future of therapeutic endoscopy. | Rui Castro Diogo Libanio Inês Pita Mário Dinis-Ribeiro | 2019 | World Journal of Gastroenterology2019，25，7： | 13 |
| 2 | Helicobacter pylori and microRNAs:Relation with innate immunity and progression of preneoplastic conditions显示文摘The accepted paradigm for intestinal-type gastric cancer pathogenesis is a multistep progression from chronic gastritis induced by Helicobacter pylori(H. pylori) to gastric atrophy, intestinal metaplasia, dysplasia and ultimately gastric cancer. The genetic and molecular mechanisms underlying disease progression are still not completely understood as only a fraction of colonized individuals ever develop neoplasia suggesting that bacterial, host and environmental factors are involved. Micro RNAs are noncoding RNAs that may influence H. pylori-related pathology through the regulation of the transcription and expression of various genes, playing an important role in inflammation, cell proliferation, apoptosis and differentiation. Indeed, H. pylori have been shown to modify micro RNA expression in the gastric mucosa and micro RNAs are involved in the immune host response to the bacteria and in the regulation of the inflammatory response. Micro RNAs have a key role in the regulation of inflammatory pathways and H. pylori may influence inflammation-mediated gastric carcinogenesis possibly through DNA methylation and epigenetic silencing of tumor suppressor micro RNAs. Furthermore, micro RNAs influenced by H. pylori also have been found to be involved in cell cycle regulation, apoptosis and epithelial-mesenchymal transition. Altogether, micro RNAs seem to have an important role in the progression from gastritis to preneoplastic conditions and neoplastic lesions and since each micro RNA can control the expression of hundreds to thousands of genes, knowledge of micro RNAs target genes and their functions are of paramount importance. In this article we present a comprehensive review about the role of micro RNAs in H. pylori gastric carcinogenesis, identifying the micro RNAs downregulated and upregulated in the infection and clarifying their biological role in the link between immune host response, inflammation, DNA methylation and gastric carcinogenesis. | Diogo Libanio Mário Dinis-Ribeiro Pedro Pimentel-Nunes | 2015 | World Journal of Clinical Oncology2015，6，5： | 7 |
| 3 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 4 | Purifi- cation of plasmid DNA vectors by aqueous two-phase extraction and hydrophobic interaction chromatography 显示文摘 | Trindade I P Diogo M M Prazeres D M F | 2005 | J Phys Chem A2005，1082，2： | 1 |
| 5 | Xanthohumol influences preadipocyte differentiation:implication of antiproliferative and apoptotic effects显示文摘 | Vanda M Rosa M Diogo P | 2008 | J Agric Food Chem2008，56，11： | 1 |
| 6 | Mitochondrial dysfunc- tion in autism spectrum disorders: a population-based study 显示文摘 | Oliveira G Diogo L Grazina M | 2005 | Dev Med Child Neurol2005，47，3： | 1 |
| 7 | Purifica- tion of plasmid DNA vectors by aqueous two-phase extrac- tion and hydrophobic interaction chromatography 显示文摘 | Trindade I P Diogo M M Prazeres D M F | 2005 | J Phys Chem A2005，1082，2： | 1 |
| 8 | Mitochondrial dysfunction inautism spectrum disorders: a population-based study显示文摘 | Oliveira G Diogo L Grazina M | 2005 | Dev Med Child Neurol2005，47，3： | 1 |
| 9 | Enantioselective synthesis and absolute configuration of the sex pheromone of Hedypathes betulinus( Coleoptera: Cerambycidae) 显示文摘 | Diogo M V Marcy G F Paulo H G Z | 2010 | Tetrahedron Letters2010，51，： | 1 |
| 10 | Chlorine and sulfur determination in extra-heavy crude oil by inductively coupled plasma optical emission spectrometry after microwave-induced combustion 显示文摘 | JULIANA S P PAOLA A M DIOGO P M | 2009 | Spectrochimica Acta Part B2009，，64： | 1 |
| 11 | Developing a reusable workflow engine显示文摘 | Ferreira Diogo M R Pinto gerreira J | 2004 | Journal of Systems Architecture2004，50，6： | 1 |
| 12 | Viscosity measurements of three ionic liq- uids using the vibrating wire technique 显示文摘 | DIOGO J C F CAETANO F J P FARELEIRA J M N A | 2013 | FluidPhase Equilibria2013，353，： | 1 |
| 13 | Purification of plasmid DNA vectors by aqueous two - phase extraction and hydrophobic interaction chromatography 显示文摘 | In^es P Trindade Maria M Diogo Duarte M F Prazeres | 2005 | Journal of Chromatography A2005，，1082： | 1 |
| 14 | Production,purification and analysis of an experimental DNA vaccine against rabies 显示文摘 | Diogo M Ribeiro M | 2001 | J Gene Med2001，，3： | 1 |
| 15 | Development of mandibular, hyoid and hypobranchial muscles in the zebrafish: homologies and evolution of these muscles within bony fishes and tetrapods显示文摘 | DIOGO R HINITS Y HUGHES S M | 2008 | BMC Developmental Biology2008，8，： | 1 |
| 16 | Studies on the retention of plasmid DNA and Escherichia coli nucleic acids by hydrophobic interaction chromatography 显示文摘 | Diogo M M Queiroz J A Prazeres D M F | 2002 | Bioseparation2002，10，45： | 1 |
| 17 | Mitochondrial dysfunction in autism spectrum disorders: a population- based study 显示文摘 | Oliveira G Diogo L Grazina M | 2005 | Dev Med Child Neuro12005，47，3： | 1 |
| 18 | Multilocus se- quence typing reveals intrafamilial transmission and microevolu- tions of Candida albicans isolates from the human digestive tract 显示文摘 | Bougnoux M E Diogo D Francois N | 2006 | J Clin Microbiol2006，44，5： | 1 |
| 19 | A hybrid collocation method for a nonlinear Volterra integral equation with weakly singular kernel显示文摘 | Rebelo M Diogo T | 2010 | Journal of Computational and Applied Mathematics2010，234，9： | 1 |
| 20 | Mouse embryonic stern cell expansion in a microcarrier-based stirred culture system显示文摘 | Fernandes A M Fernandes T G Diogo M M | 2007 | J Biotechnol2007，132，2： | 1 |
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