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| 1 | Polymethylmethacrylate bone cements and additives: A review of the literature显示文摘Polymethylmethacrylate(PMMA) bone cement technology has progressed from industrial Plexiglass administration in the 1950 s to the recent advent of nanoparticle additives. Additives have been trialed to address problems with modern bone cements such as the loosening of prosthesis, high post-operative infection rates, and inflammatory reduction in interface integrity. This review aims to assess current additives used in PMMA bone cements and offer an insight regarding future directions for this biomaterial. Low index(< 15%) vitamin E and low index(< 5 g) antibiotic impregnated additives significantly address infection and inflammatory problems, with only modest reductions in mechanical strength. Chitosan(15% w/w PMMA) and silver(1% w/w PMMA) nanoparticles have strong antibacterial activity with no significant reduction in mechanical strength. Future work on PMMA bone cements should focus on trialing combinations of these additives as this may enhance favourable properties. | Manit Arora Edward KS Chan Sunil Gupta Ashish D Diwan | 2013 | World Journal of Orthopedics2013，4，2： | 10 |
| 2 | Rising challenge of multidrug-resistant tuberculosis in China:a predictive study using Markov modeling显示文摘Background:Multidrug-resistant tuberculosis(MDR-TB)is on the rise in China.This study used a dynamic Markov model to predict the longitudinal trends of MDR-TB in China by 2050 and to assess the effects of alternative control measures.Methods:Eight states of tuberculosis transmission were set up in the Markov model using a hypothetical cohort of 100000 people.The prevalence of MDR-TB and bacteriologically confirmed drug-susceptible tuberculosis(DS-TB+)were simulated and MDR-TB was stratified into whether the disease was treated with the recommended regimen or not.Results:Without any intervention changes to current conditions,the prevalence of DS-TB+was projected to decline 67.7%by 2050,decreasing to 20 per 100000 people,whereas that of MDR-TB was expected to triple to 58/100000.Furthermore,86.2%of the MDR-TB cases would be left untreated by the year of 2050.In the case where MDR-TB detection rate reaches 50%or 70%at 5%per year,the decline in prevalence of MDR-TB would be 25.9 and 36.2%respectively.In the case where treatment coverage was improved to 70%or 100%at 5%per year,MDR-TB prevalence in 2050 would decrease by 13.8 and 24.1%,respectively.If both detection rate and treatment coverage reach 70%,the prevalence of MDR-TB by 2050 would be reduced to 28/100000 by a 51.7%reduction.Conclusions:MDR-TB,especially untreated MDR-TB,would rise rapidly under China’s current MDR-TB control strategies.Interventions designed to promote effective detection and treatment of MDR-TB are imperative in the fights against MDR-TB epidemics. | Bing-Ying Li Wen-Pei Shi Chang-Ming Zhou Qi Zhao Vinod K Diwan Xu-Bin Zheng Yang Li Sven Hoffner Biao Xu | 2020 | Infectious Diseases of Poverty2020，9，3： | 3 |
| 3 | Increasing prevalence of nonalcoholic steatohepatitis as an indication for liver transplantation显示文摘 | R. Cutler Quillin Gregory C. Wilson Jeffrey M. Sutton Dennis J. Hanseman Flavio Paterno Madison C. Cuffy Ian M. Paquette Tayyab S. Diwan E. Steve Woodle Daniel E. Abbott Shimul A. Shah | 2014 | Surgery2014，，4： | 2 |
| 4 | Preoperative magnetic resonance Imaging screening for a surgical decision regarding the approach for anterior spine fusion at the clervicothoracic junction显示文摘 | Fraser J F Diwan A D Peterson M | 2002 | SPINE2002，27，7： | 2 |
| 5 | 农村基层卫生服务研究课题报告显示文摘农村基层卫生服务研究反映的是农村最基本的卫生服务状况,包括门诊与住院、妇幼保健与计划免疫以及地方病防治等。本文通过安徽、江西与江苏三省六县的研究表明:门诊与住院服务都受到当地医疗保健制度的影响,常见的门诊与住院病种是呼吸道疾病与消化道疾病,已婚育龄妇女节育率平均为94.2%,女性结扎率在三省有差别,儿童计划免疫覆盖率平均为84.7%,医疗保健制度与父母受教育程度是计划免疫的主要影响因素,血吸虫病防治已取得了巨大的成绩,居民感染率大幅度下降,已基本达到了控制的目标。研究结果还表明:医疗保健制度对基层卫生服务的影响较大,因此加强农村医疗保健制度的研究应是当前农村卫生工作的重点之一。 | 姜庆伍 Lennart Bogg 董恒进 王克利 赵根明 Vinod Diwan 袁鸿昌 | 1997 | 中国初级卫生保健1997，11，5： | 2 |
| 6 | Viral Genotypes and Associated Risk Factors of Hepatocellular Carcinoma in India显示文摘Objective This study aims to investigate the etiological relationship among hepatitis B virus(HBV),hepatitis C virus(HCV),and alcohol as risk factors in a cohort of hepatocellular carcinoma(HCC) patients from India.The clinical and biochemical profiles and tumor characteristics in the HCC cases were also evaluated. Methods A total of 357 consecutive cases of HCC fulfilling the diagnostic criteria from the Barcelona-2000 EASL conference were included in the study.The blood samples were evaluated for serological evidence of HBV and HCV infection,viral load,and genotypes using serological tests,reverse transcription-polymerase chain reaction,and restriction fragment length polymorphism. Results The male/female ratio for the HCC cases was 5.87:1.Majority of the HCC patients(33.9% ) were 50 to 59 years of age,with a mean age of 4±13.23 years.More than half the cases(60.8% ) had underlying cirrhosis at presentation.Among the HCC patients,68.9% were HBV related,21.3% were HCV related,18.8% were alcoholic,and 18.2% were of cryptogenic origin.The presence of any marker positive for HBV increased the risk for developing HCC by almost 27 times[OR:27.33;(12.87-60.0)].An increased risk of 10.6 times was observed for HCC development for cases positive for any HCV marker[OR:10.55;(3.13-42.73)].Heavy alcohol consumption along with HCV RNA positivity in cirrhotic patients was found to be a risk for developing HCC by 3 folds[OR:3.17;(0.37-70.71)]. Conclusions Patients of chronic HBV infection followed by chronic HCV infection were at higher risk of developing HCC in India. Chronic alcohol consumption was found to be a risk factor in cirrhotic cases only when it was associated with HCV RNA positivity. Most of the patients had a large tumor size(>5 cm) with multiple liver nodules,indicating an advanced stage of the disease thus making curative therapies difficult. | Manash Pratim Sarma Mohammad Asim Subhash Medhi Thayumanavan Bharathi Richa Diwan Premashis Kar | 2012 | Clinical oncology and cancer resexreh2012，9，3： | 2 |
| 7 | Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support显示文摘 | Scot J. Matkovich Derek J. Van Booven Keith A. Youker Guillermo Torre-Amione Abhinav Diwan William H. Eschenbacher Lisa E. Dorn Mark A. Watson Kenneth B. Margulies Gerald W. Dorn | 2009 | Circulation2009，，： | 2 |
| 8 | Nitric oxide regulates alkaline phosphatase activity in rats fracture callus explant cultures显示文摘 | Namkung-Matthai H Diwan A Mason RS | 2000 | Redox Rep2000，5，23： | 1 |
| 9 | Methods of developing a core collection of annual Medicago species显示文摘 | Diwan N M S Mclntosh G R Bauchan | 1995 | Theor Appl Genet1995，90，6： | 1 |
| 10 | The timing of surgery in lumbar disc pro- lapse : A systematic review 显示文摘 | Sabnis AB Diwan AD | 2014 | Indian J Orthop2014，48，2： | 1 |
| 11 | Chronic inorganic arsenic exposure induces hepatic globaland individualgene hypomethylation:implications for arsenic hepatocarcinogenesis显示文摘 | ChenH Li J Diwan BA | 2004 | Carcinogenesis2004，25，9： | 1 |
| 12 | Method of developing a core collection of annual Medicago species显示文摘 | DIWAN N MCLNTOSH M S BAUCHAN G R | 1995 | Theoretical & Applied Genetics1995，90，： | 1 |
| 13 | Metallothionein protection of cad- mium toxicity 显示文摘 | Klaassen C D Liu J Diwan B A | 2009 | Toxicology and Applied Pharmacology2009，238，3： | 1 |
| 14 | Pegylation enhances protein stability during encapsulation in PLGA microspheres显示文摘 | Park TG | 2001 | J Controlled Release2001，73，2： | 1 |
| 15 | Laparoscopic uterosacral ligament uterine suspension compared with vaginal hysterectomy with vaginal vault suspension for uterovaginal prolapse 显示文摘 | Diwan A Rardin CR Strohsnitter WC | 2005 | Int J Gynecol Obstet2005，17，： | 1 |
| 16 | Mechanistic Studies of Combustion Simulated Hydrogen Generation from Sodium Borohydride 显示文摘 | Diakov V Diwan M | 2007 | Chemical Engineering Science2007，62，： | 1 |
| 17 | Targeted Overexpression of Noneleavable and Secreted Forms of Tumor Necrosis Factor Provokes Disparate Cardiae Phenotypes显示文摘 | Diwan A Dibbs Z Nemoto S | 2004 | Circulation2004，109，2： | 1 |
| 18 | Ameliorative effects of Ocimum sanctum in sciatic nerve transection-induced neuropathy in rats显示文摘 | Muthuraman A Diwan V Jaggi AS Singh N Singh D | 2008 | J Ethnopharmacol2008，120，1： | 1 |
| 19 | Current concepts in intervertebral disc restoration显示文摘 | Diwan AD Parvataneti HK Khan SN | | 0，，03： | 1 |
| 20 | Promotion by Helicobacter hepaticus- induced hepatitis of hepatic tumors initated by N-nitrosodimethylamine in male A/J Crmice 显示文摘 | Diwan BA Ward JM Ramljak D | 1997 | Toxicol Pathol1997，25，6： | 1 |
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