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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 3 | Time to clinical response and remission for therapeutics in inflammatory bowel diseases: what should the clinician expect, what should patients be told?显示文摘An awareness of the expected time for therapies to induce symptomatic improvement and remission is necessary for determining the timing of follow-up, disease(re)assessment, and the duration to persist with therapies, yet this is seldom reported as an outcome in clinical trials. In this review, we explore the time to clinical response and remission of current therapies for inflammatory bowel disease(IBD) as well as medication, patient and disease related factors that may influence the time to clinical response. It appears that the time to therapeutic response varies depending on the indication for therapy(Crohn's disease or ulcerative colitis). Agents with the most rapid time to clinical response included corticosteroids, calcineurin inhibitors, exclusive enteral nutrition, aminosalicylates and anti-tumor necrosis factor therapy which will work in most patients within the first 2 mo. Vedolizumab,methotrexate and thiopurines had a longer time to clinical response and can take several months to achieve maximal efficacy. Factors affecting the time to clinical response of therapies included use of concomitant therapy, disease duration, smoking status, disease phenotype and advanced age. There appears to be marked variation in time to clinical response for therapies used in IBD which is further influenced by disease and patient related factors. Understanding the expected time to therapeutic response is integral to inform further decision making, maintain a patientcentered approach and ensure treatment is given an appropriate timeframe to achieve maximal benefit prior to cessation. | Abhinav Vasudevan Peter R Gibson Daniel R van Langenberg | 2017 | World Journal of Gastroenterology2017，23，35： | 4 |
| 4 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 5 | Indian medicinal herbs as sources of antioxidants显示文摘 | Shahin Sharif Ali Naresh Kasoju Abhinav Luthra Angad Singh Hallihosur Sharanabasava Abhishek Sahu Utpal Bora | 2007 | Food Research International2007，，1： | 4 |
| 6 | 系统评价与Meta分析:高氟牙膏与标准含氟牙膏的防龋效果比较显示文摘目的:对比高氟牙膏(≥2500ppm)与标准含氟牙膏(≤1500ppm)的龋齿预防功效。材料与方法:采用随机对照试验(RCTs)和聚类随机试验比较高氟牙膏(≥2500ppm)和低浓度含氟牙膏(≤1500ppm)的防龋效果,随访时间至少6个月。随机效应模型用于评估所使用的两种牙膏在龋齿增加方面的平均差异。固定效应模型用于评定高浓度含氟牙膏相较于低氟浓度牙膏的防龋效果。当结果存在异质性时,进行亚组分组和敏感性分析。设定p | Abhinav Singh Bharathi M.Purohit 辛月娇(译) 张珊珊(审) 郑树国(审) | 2018 | 中国口腔医学继续教育杂志2018，21，5： | 3 |
| 7 | Post splenectomy related pulmonary hypertension显示文摘Splenectomy predisposes patients to a slew of infectious and non-infectious complications including pulmonary vascular disease. Patients are at increased risk for venous thromboembolic events due to various mechanisms that may lead to chronic thromboembolic pulmonary hypertension(CTEPH). The development of CTEPH and pulmonary vasculopathy after splenectomy involves complex pathophysiologic mechanisms, some of which remain unclear. This review attempts to congregate the current evidence behind our understanding about the etio-pathogenesis of pulmonary vascular disease related to splenectomy and highlight the controversies that surround its management. | Atul V Palkar Abhinav Agrawal Sameer Verma Asma Iftikhar Edmund J Miller Arunabh Talwar | 2015 | World Journal of Respirology2015，5，2： | 3 |
| 8 | Baastrup's disease: The kissing spine显示文摘A 67-year-old male presented with a gradually progressive low back pain of 2 years duration. The patient was leading a retired life and there was no history of chronic fever or significant trauma. There was no radiation of pain or any features suggestive of claudication. There was no history of any comorbidity. The pain was aggravated with extension of the spine and relieved with flexion. There was no swelling or neurological deficit, but muscle spasm was present. Radiographs of the spine revealed degenerative changes in the lumbosacral spine, along with articulation of spinous processes at in lumbar spine at all levels level suggestive of Baastrup's disease, commonly known as 'kissing spine'. Routine blood investigations were within normal limits. The patient was managed conservatively. He was given a week's course of analgesics and muscle relaxants and then started on spinal flexion exercises, with significant improvement being noted at 6 months follow up. | Amit Singla Vivek Shankar Samarth Mittal Abhinav Agarwal Bhavuk Garg | 2014 | World Journal of Clinical Cases2014，2，2： | 2 |
| 9 | Improving sessile serrated adenoma detection rates with high definition colonoscopy:A retrospective study显示文摘BACKGROUND Sessile serrated adenomas(SSAs)are important premalignant lesions that are difficult to detect during colonoscopy due to poor definition,concealment by mucous caps,and flat appearance.High definition(HD)colonoscopy may uniquely aid in the detection of these inconspicuous lesions compared to standard definition(SD)colonoscopes.In the absence of existing clinical guidelines to obligate the use of HD colonoscopy for colorectal cancer screening in average-risk patients,demonstrating the benefit of HD colonoscopy on SSA detection rate(SSADR)may help strengthen the evidence to recommend its use in all settings.AIM To evaluate the benefit of HD colonoscopy compared to SD colonoscopy on SSADR in average-risk patients undergoing screening colonoscopy.METHODS Data from screening colonoscopies for patients aged 50-76 years two years before and two years after the transition from SD colonoscopy to HD colonoscopy at our large,academic teaching center were collected.Patients with symptoms of colorectal disease,positive occult blood test,history of colon polyps,cancer,polyposis syndrome,inflammatory bowel disease or family history of colon cancer or polyps were excluded.Patients whose endoscopists did not perform colonoscopies both before and after scope definition change were also excluded.Differences in individual endoscopist SSADR,average SSADR,and overall SSADR with SD colonoscopy vs HD colonoscopy were also evaluated for significance.RESULTS A total of 3657 colonoscopies met eligibility criteria with 2012 colonoscopies from the SD colonoscopy period and 1645 colonoscopies from the HD colonoscopy period from a pool of 11 endoscopists.Statistically significant improvements of 2.30%in mean SSADR and 2.53%in overall SSADR were noted with HD colonoscopy(P=0.00028 and P=0.00849,respectively).On the individual level,three endoscopists experienced statistically significant benefit with HD colonoscopy(+5.74%,P=0.0056;+4.50%,P=0.0278;+4.84%,P=0.03486).CONCLUSION Our study suggests that HD colonoscopy statistically significantly improves sessile serrated adenoma detection rate in the screening of average risk patients during screening colonoscopy.By improving the detection and removal of these lesions,adoption of HD colonoscopy may reduce the significant premalignant burden of sessile serrated adenomas. | Abhinav Sehgal Soorya Aggarwal Rohan Mandaliya Thomas Loughney Mark C Mattar | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，4： | 2 |
| 10 | Deep learning vs conventional learning algorithms for clinical prediction in Crohn's disease: A proof-of-concept study显示文摘BACKGROUND Traditional methods of developing predictive models in inflammatory bowel diseases(IBD)rely on using statistical regression approaches to deriving clinical scores such as the Crohn's disease(CD)activity index.However,traditional approaches are unable to take advantage of more complex data structures such as repeated measurements.Deep learning methods have the potential ability to automatically find and learn complex,hidden relationships between predictive markers and outcomes,but their application to clinical prediction in CD and IBD has not been explored previously.AIM To determine and compare the utility of deep learning with conventional algorithms in predicting response to anti-tumor necrosis factor(anti-TNF)therapy in CD.METHODS This was a retrospective single-center cohort study of all CD patients who commenced anti-TNF therapy(either adalimumab or infliximab)from January 1,2010 to December 31,2015.Remission was defined as a C-reactive protein(CRP)<5 mg/L at 12 mo after anti-TNF commencement.Three supervised learning algorithms were compared:(1)A conventional statistical learning algorithm using multivariable logistic regression on baseline data only;(2)A deep learning algorithm using a feed-forward artificial neural network on baseline data only;and(3)A deep learning algorithm using a recurrent neural network on repeated data.Predictive performance was assessed using area under the receiver operator characteristic curve(AUC)after 10×repeated 5-fold cross-validation.RESULTS A total of 146 patients were included(median age 36 years,48%male).Concomitant therapy at anti-TNF commencement included thiopurines(68%),methotrexate(18%),corticosteroids(44%)and aminosalicylates(33%).After 12 mo,64%had CRP<5 mg/L.The conventional learning algorithm selected the following baseline variables for the predictive model:Complex disease behavior,albumin,monocytes,lymphocytes,mean corpuscular hemoglobin concentration and gamma-glutamyl transferase,and had a cross-validated AUC of 0.659,95%confidence interval(CI):0.562-0.756.A feed-forward artificial neural network using only baseline data demonstrated an AUC of 0.710(95%CI:0.622-0.799;P=0.25 vs conventional).A recurrent neural network using repeated biomarker measurements demonstrated significantly higher AUC compared to the conventional algorithm(0.754,95%CI:0.674-0.834;P=0.036).CONCLUSION Deep learning methods are feasible and have the potential for stronger predictive performance compared to conventional model building methods when applied to predicting remission after anti-TNF therapy in CD. | Danny Con Daniel R van Langenberg Abhinav Vasudevan | 2021 | World Journal of Gastroenterology2021，27，38： | 2 |
| 11 | Analysis of national and single-center incidence and survival after liver transplantation for hepatoblastoma. New trends and future opportunities显示文摘 | Ruy J. Cruz Sarangarajan Ranganathan George Mazariegos Kyle Soltys Navdeep Nayyar Qing Sun Geoffrey Bond Peter H. Shaw Kimberly Haberman Lakshmanan Krishnamurti Abhinav Humar Rakesh Sindhi | 2012 | Surgery2012，，： | 2 |
| 12 | Integrated optical switch matrices for packet data networks显示文摘Integrated circuit technologies are enabling intelligent,chip-based,optical packet switch matrices.Rapid real-time reconfigurability at the photonic layer using integrated circuit technologies is expected to enable cost-effective,energy-efficient,and transparent data communications.InP integrated photonic circuits offer high-performance amplifiers,switches,modulators,detectors,and de/multiplexers in the same wafer-scale processes.The complexity of these circuits has been transformed as the process technologies have matured,enabling component counts to increase to many hundreds per chip.Active–passive monolithic integration has enabled switching matrices with up to 480 components,connecting 16 inputs to 16 outputs.Integrated switching matrices route data streams of hundreds of gigabits per second.Multi-path and packet time-scale switching have been demonstrated in the laboratory to route between multiple fibre connections.Wavelength-granularity routing and monitoring is realised inside the chip.In this paper,we review the current status in InP integrated photonics for optical switch matrices,paying particular attention to the additional on-chip functions that become feasible with active component integration.We highlight the opportunities for introducing intelligence at the physical layer and explore the requirements and opportunities for cost-effective,scalable switching. | Ripalta Stabile Aaron Albores-Mejia Abhinav Rohit Kevin A.Williams | 2016 | Microsystems & Nanoengineering2016，2，1： | 2 |
| 13 | 13例髓内高分化骨肉瘤的临床、影像及病理学观察显示文摘背景与目的:髓内高分化骨肉瘤发病率低,临床影像及病理检查均易误诊,而因误诊导致的不当治疗对患者预后影响极大。本文旨在探讨髓内高分化骨肉瘤的临床、影像及病理学特点,随访观察其临床规律。方法:收集2000年1月—2012年6月在河北医科大学第三医院就诊并最终经组织学诊断为髓内高分化骨肉瘤的11例病例,另外2例为26年前确诊的病例。回顾性分析该组13例髓内高分化骨肉瘤的临床、影像及病理学资料,并随访患者的预后。随访时间2例为26年,11例为6~101个月,平均37.5个月。结果:13例中男性10例,女性3例。初诊年龄19~52岁,平均32岁。12例病变位于长骨,1例位于髋臼Ⅱ区。除2例病变相对局限,其他病变范围广泛,长骨病变全部涉及干骺端区,可向骨干或骨端延伸。其影像表现虽有一些规律,但缺乏特征性,总体发展缓慢,部分有恶性的征象。该组病变多边界不清,全部有骨皮质破坏、中断,粗大骨嵴常见,骨膜反应和软组织肿块较少见。组织学主要为梭形细胞成分,仅有轻度异型。随访发现,采用截肢及段切治疗者均无复发及转移;采用病灶搔刮治疗者4例,随访过程中3例死亡,其中2例死于肿瘤复发、转移。结论:髓内高分化骨肉瘤好发于长骨干骺端,以股骨远端最为多见。影像表现缺乏特征性。组织学诊断要密切结合临床及影像。病变切除完全者预后良好,病灶刮除或切除不彻底将导致反复复发,并促其转化为高度恶性肿瘤。 | 刘俊茹 吴天昊 Abhinav Kumar Seemon Petrus Christopasak 史云恒 刘杰 于宝海 吴文娟 | 2012 | 中国癌症杂志2012，22，9： | 2 |
| 14 | BISAP评分与Ranson评分和CT严重指数预测印度急性胰腺炎患者并发症发生率和病死率的比较研究显示文摘目的:本研究通过印度中东部地区一家三甲医院,前瞻性评估急性胰腺炎严重度床边指数(BISAP)评分预测急性胰腺炎患者病死率及疾病进展中间指标的准确性,从而为贫困人群提供一个经济、有效的预后预测方法。方法:2012-2014年间我们中心连续收治的119例急性胰腺炎患者纳入研究。起病24 h内对所有病例进行BISAP评分,同时也进行Ranson评分和CT严重指数(CTSI)评估。采用趋势和判别分析来对这三种评分系统对病死率的预测价值进行评价。通过受试者操作特征(ROC)曲线评估这三种评分系统对急性胰腺炎患者病死率及疾病进展中间指标(器官衰竭和胰腺坏死)的预测情况。结果:119例入组病例中42例(35.2%)出现器官衰竭,定义为重症急性胰腺炎,47例(39.5%)发生胰腺坏死,12例(10.1%)死亡。BISAP评分预测重症急性胰腺炎、胰腺坏死和死亡的曲线下面积(AUC)分别为0.962、0.934和0.846。Ranson评分预测重症急性胰腺炎(AUC 0.956)和死亡(AUC 0.841)的准确性稍低于BISAP评分。CTSI在预测胰腺坏死方面的准确性最高,AUC为0.958。以≥3分作为截点,BISAP评分预测病死率的敏感性和特异性分别为100%和69.2%。结论:BISAP评分简单实用,在急性胰腺炎起病24 h内即可鉴别出高危死亡风险及高危疾病进展风险的患者。这种风险分层方法可用以提高临床诊治,并有助于临床研究中的病例入组。 | Jitin Yadav Sanjay Kumar Yadav Satish Kumar Ranjan George Baxla Dipendra Kumar Sinha Pankaj Bodra Ram Chandra Besra Babu Mani Baski Om Prakash Abhinav Anand | 2016 | Gastroenterology Report2016，4，3： | 2 |
| 15 | Reciprocal Regulation of Myocardial microRNAs and Messenger RNA in Human Cardiomyopathy and Reversal of the microRNA Signature by Biomechanical Support显示文摘 | Scot J. Matkovich Derek J. Van Booven Keith A. Youker Guillermo Torre-Amione Abhinav Diwan William H. Eschenbacher Lisa E. Dorn Mark A. Watson Kenneth B. Margulies Gerald W. Dorn | 2009 | Circulation2009，，： | 2 |
| 16 | Intravesical bacillus Calmette-Guerin(BCG)in treating non-muscle invasive bladder cancer—analysis of adverse effects and effectiveness of two strains of BCG(Danish 1331 and Moscow-I)显示文摘Objective:To compare the differences in adverse effects and efficacy profile between bacillus Calmette-Guerin(BCG)Danish 1331 and BCG Moscow-I strain in management of non-muscle invasive bladder cancer.Methods:Clinical data of 188 cases of non-muscle invasive bladder cancer treated with BCG between January 2008 and December 2018 in our institute were collected prospectively and analysed retrospectively,and 114 patients who completed a minimum of 12 months of follow-up were analysed.Patient and tumor characteristics,strain of BCG,adverse effects,and tumor progression were included for analysis.Intravesical BCG was instilled in intermediate-and high-risk patients.Six weeks of induction BCG,followed by three weekly maintenance BCG at 3,6,12,18,and 24 months was advised in high-risk patients.Results:Overall 68 patients received BCG Danish 1331 strain and 46 patients received Moscow-I strain.Patient and tumor characteristics were well balanced between the two groups.The median follow-up period was 42.5 months and 34.5 months in Danish 1331 and Moscow-I groups,respectively.Adverse events like dropout rate,antitubercular treatment requirement,and need of cystectomy were higher in Moscow-I group(n=31,67.4%)when compared to Danish 1331 strain(n=33,48.5%)(p=0.046).On direct comparison between Danish 1331 and Moscow-I strain,there was similar 3-year recurrence-free survival(80.0%vs.72.9%)and 3-year progression-free survival(96.5%vs.97.8%).Conclusion:Study results suggest no significant differences between Danish 1331 and Moscow-I strain in recurrence-free survival and progression-free survival,but a significantly higher incidence of moderate to severe adverse events in BCG Moscow-I strain. | Yuvaraja B.Thyavihally Preetham Dev Santosh Waigankar Abhinav Pednekar Nevitha Athikari Abhijit Raut Archan Khandekar Naresh Badlani Ashishkumar Asari | 2022 | Asian Journal of Urology2022，9，2： | 2 |
| 17 | What makes pairs look like pairs显示文摘 | Carl Doersch Saurabh Singh Abhinav Gupta | 2012 | Acm Transactions on Graphics2012，31，4： | 1 |
| 18 | A Hybrid Multi-Agent Based Particle Swarm Optimizstion Algorithm for Economic Power Dispatch 显示文摘 | Rajesh Kumar Debendra Sharma Abhinav Sadu | 2011 | Electrical Power and Energy Systems2011，33，1： | 1 |
| 19 | MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts显示文摘 | Scot J. Matkovich Wei Wang Yizheng Tu William H. Eschenbacher Lisa E. Dorn Gianluigi Condorelli Abhinav Diwan Jeanne M. Nerbonne Gerald W. Dorn | 2010 | Circulation Research2010，，： | 1 |
| 20 | Occurrence of phthalic acid esters in Gomti River Sediment, India显示文摘 | Abhinav Srivastava Vinod P. Sharma Ranu Tripathi Rakesh Kumar Devendra K. Patel Pradeep Kumar Mathur | 2010 | Environmental Monitoring and Assessment (-)2010，，1： | 1 |
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