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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Relationship between skin fold thickness and insulin resistance in the essential hypertensive patients in Vietnam显示文摘Previous studies reported a close relationship between obesity and insulin resistance in the essential hypertensive patients. Objective In this study, we examined the relationship between the skin fold thickness and insulin resistance then developed a formula to estimate the insulin resistance index according to the skin fold thickness in the essential hypertensive patients. Subjects and Methods Medical records of 80 patients (37 males, 43 females) were reviewed and the data were tabulated. Anthropometric indexes (including height, weight, waist circumference, hip circumference, and skins fold thickness at 5 fatty difference points on the Erdheim diagram), fasting plasma glucose and insulin concentration were recorded. The mean age was 57.0±9.2 years. The insulin resistance index was calculated following the Homeostasis Model Assessment (HOMA) formula. Results Compared with the group with BMI<23kg/m2, the group with BMI≥23 kg/m2 had higher fasting insulin concentration (8.85 ± 4.97 pmol/L vs 15.60 ± 8.70 pmol/L, P<0.001 ) and higher insulin resistance index in (2.15±1,24 vs 3.76±2.22, P<0.001). No significant difference in fasting plasma insulin concentration,insulin resistance index between male and female was observed (P>0.05). There was a positive correlation between skin fold thickness and the fasting insulin concentration and insulin resistance index. The skin fold thickness at point A8 had the best coefficient correlated with fasting plasma insulin(r=0.79, P<0.001) and insulin resistance index (r= 0.79, P < 0.001). A formula to estimate the insulin resistance index by skin fold thickness at point A8 as: Insulin resistance index = 0.12 × [skin fold thickness at A8 point (mm)] - 1.Conclusion: In the essential hypertensive patients, the formula to estimate insulin resistance index as 0.12 × [skin fold thickness at A8 point (mm)]-1 may predict accurately the level of insulin resistance. | Toan C Nguyen Khoa TA Pham Quyen TL Do Cuong T Nguyen Diep D Nguyen Vinh G Le Cong D Nguyen | 2005 | Journal of Geriatric Cardiology2005，2，4： | 4 |
| 3 | Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘 | Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S | | 0，，03： | 1 |
| 4 | SAR image autofocus by sharpness optimization:a theoretical study显示文摘 | Morrison R L Do M N Munson D C | | 0，，09： | 1 |
| 5 | Resveratrol attenuates cisplatin-induced nephrotoxicity in rats显示文摘 | do AMARAL C L FRANCESCATO H D C COIMBRA T M | 2008 | Archives of Toxicology2008，82，6： | 1 |
| 6 | SLC2A9 influences uric acid concentrations with pro-nounced sex-specific effects显示文摘 | Do ring A Gieger C Mehta D | 2008 | Nat Genet2008，40，： | 1 |
| 7 | Associative Classification with Artificial Immune System显示文摘 | Do T D Hui S C Fong A C M | 2009 | IEEE Trans on Evol Comput2009，2，13： | 1 |
| 8 | Inverse dynamic analysis and simulation of a platform type of robot 显示文摘 | DO W Q D YANG D C H | 1988 | Int Journal of Robotic Systems1988，5，3： | 1 |
| 9 | Identification and chromosomal organization of two rye genome-specific RAPD products useful as introgression markers in wheat显示文摘 | KO J M DO G S SUH D Y SEO B B SHIN D C MOON H P | 2002 | Genome2002，45，1： | 1 |
| 10 | Electronic structure of oxygen deficient BaTiO_3显示文摘 | Do D C Jaichan L | 2006 | Integrated Ferroelectrics2006，84，1： | 1 |
| 11 | Design, fabrication and modelling of MEMS-based microthrusters for space application 显示文摘 | C Rossi T Do Conto D Est'eve | 2001 | Smart Materials and Structures2001，，10： | 1 |
| 12 | Preliminary formu- lation development for aqueous surfactant-based soybean oil ex traction显示文摘 | Do L D Stevens T L Kibbey T C G | 2014 | Industrial Crops and Products2014，，62： | 1 |
| 13 | Correlation between facial measurements and the meSi0distal width of the maxillary anterior teeth显示文摘 | Gomes VL Goncalves LC do Prado C j et d | 2006 | J Esther iRestor Dent2006，18，4： | 1 |
| 14 | Feasibility of nitrification/denitrification in a sequencing batch biofilm reactor with liquid circulation applied to post-treatment 显示文摘 | C S A do Canto Rodrig J A D Ratusznei S M | 2008 | Bioresource Technology2008，99，： | 1 |
| 15 | Thermal modeling of a cylindrical LiFePO4 graphite lithium-ion battery显示文摘 | FORGEZA C DO D V FRIEDRICH G | | 0，，： | 1 |
| 16 | Thermal Modelling of a Cylindrical LiFePO4/Graphite Lithium- ion Battery 显示文摘 | FORGEZ C DO D V FRIEDRICH G | 2010 | J Power Sources2010，195，9： | 1 |
| 17 | Spontaneous external bil- iary fistula: a rare complication of cholangiocarcinoma 显示文摘 | Song I D Oh H C Do J H | 2011 | Intern Med2011，50，5： | 1 |
| 18 | Using contextual spaces for image re-ranking and rank ag- gregation显示文摘 | PEDRONETTE D C G TORRES R do S CALUMBY R T | 2014 | Multimedia Tools and Applications2014，69，3： | 1 |
| 19 | Improved cohesive stress integration schemes for cohesive zone elements显示文摘 | DO B C LIU W YANG Q D ei al | 2013 | Eng Fracture Mech2013，107，7： | 1 |
| 20 | Output feedback control of Markov jump linear systems in continuous-time 显示文摘 | de Farias D P Geromel J C do Val J | 2000 | IEEE Trans on Automatic Control2000，45，5： | 1 |
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