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	题名	作者	年代	出处	被引量
1	Response evaluation of chemotherapy in metastatic colorectal cancer by contrast enhanced ultrasound显示文摘AIM:To evaluate whether contrast enhanced ultrasound(CEUS) might also be used for response prediction and early response evaluation in patients receiving bevacizumab based chemotherapy for metastasized colorectal cancer.METHODS:Thirty consecutive patients with non primary resectable liver metastases from colorectal cancer underwent CEUS before treatment(CEUS date 1) and before the second(CEUS date 2) and fourth(CEUS date 3) cycle of bevacizumab based chemotherapy.Three parameters [PEAK,Time to peak(TTP) and RISE RATE]were correlated with radiological response.RESULTS:For neoadjuvant purpose a reduction of tumour mass was required to assume clinical response.Based on these response criteria there was a significant(P < 0.001) correlation in TTP between metastases of responders(9.08 s) and non-responders(14.76 s) archived on CEUS date 1.By calculating a standardized quotient(metastases divided by normal liver tissue) we were able to define a cut off,predicting response with a sensitivity of 92.3 % and a specificity of 100 %.To reflect a palliative intention only those patients with progressive disease were classified as non-responders.In this stetting TTP was also significantly(P < 0.01) different between responders and non-responders.In contrast,Peak and Rise rate did not show any significant difference between responder and non-responder.CONCLUSION:CEUS might serve as a surrogate marker to predict treatment response in patients with metastasized colorectal cancer who receive antiangiogenic therapy.	Ramin Schirin-Sokhan Ron Winograd Christoph Roderburg Jhenee Bubenzer Nicole Cabral do ó Dorothee Guggenberger Hartmut Hecker Christian Trautwein Jens J W Tischendorf	2012	World Journal of Gastroenterology2012，18，6：	16
2	Insulation coordinationconsidering the switching overvoltage waveshape,partⅡ:ap-plication and results显示文摘	Nunes R R Do Couto Boaventura W	2009	IEEE Transactions on Power Deliver-y2009，24，4：	1
3	Pecutaneous coronary interven tion in the current era compared with 1985-1986:the National Heart,Lung,and Blood Institute Registries 显示文摘	William DO Holubkov Yeh W	2000	Circulation2000，102，：	1
4	Isolation and characterization of a cDNA encoding chalcone synthase homolog from Phalaenopsis显示文摘	Hsu W S Do Y Y Huang P L	1997	Plant Physiol1997，113，：	1
5	Multiple primary cancers in patients with non-Uodgkin's lymphoma显示文摘	Song H Do Y Lee W	2006	J Clin Oncol2006，，17：	1
6	Tumor necrosis factor α-induced interleukin-32 is positively regulated via the Syk/protein kinase Cδ/JNK pathway in rheumatoid synovial fibroblasts显示文摘	Mun S H Kim J W Nah S S Ko N Y Lee J H Kim J D Kim do K Kim H S Choi J D Kim S H Lee C K Park S H Kim B K Kim H S Kim Y M and Choi W S		0，，03：	1
7	Vascular targeting of solid tumours: a major ' inverse' volume -response relationship following combretastatin A - 4 phosphate treatment of rat rhabdomyosarcomas显示文摘	Landuyt W Yerdoes O Darius DO	2000	Eur J Cancer2000，36，：	1
8	Paried electrooxidative degradation of phenol with in situ electro generated hydrogen peroxide and hypochlorite显示文摘	Yeh W C	1996	J Appl Electrochem1996，26，：	1
9	Ring opening of 1,2 - and1,3- dimethylcyclohexane on iridium catalysts 显示文摘	Do P T Alvarez W E f Resasco D E	2006	Journal ofCatalysis2006，238，2：	1
10	Neuromuscular facilitation and blockade induced by L - arginine and nitric oxide in the rat isolated diaphragm 显示文摘	Ambiel CR and Alves - Do - Prado W	1997	GenPharmacol1997，28，：	1
11	Sigma 1 Receptor plays a prominent role in IL-24-induced cancer-specific apoptosis 显示文摘	Do W Herrera C Mighty J	2013	Biochem Biophys Res Commun2013，439，2：	1
12	Expression of cell metabolism- related genes in different molecular subtypes of triple-negative breast cancer显示文摘	Jeon H M Kim do H Jung W H	2013	Tumori2013，99，4：	1
13	Fate of donor mitochondrial DNA in cloned bovine embryos produced by microinjection of cumulus cells显示文摘	Do J T Lee J W Lee B Y	2002	Biol Reprod2002，67，2：	1
14	Differential expression and in situ localization of a pepper defensin (CADEF1) gene in response to pathogen infection, abiotic elicitors and environmental stresses in Capsicum annuum 显示文摘	Do H M Lee S C Jung H W	2004	Plant Sci2004，166，：	1
15	Steroid hormone receptors in human coloncancers显示文摘	Alford T C Do H M Geelhoed G W	1979	Cancer1979，43，3：	1
16	Uterine papillary serous carcinoma: patterns of failure and survival显示文摘	Wang W Do V Hogg R	2009	Aust N Z J Obstet Gynaecol2009，49，4：	1
17	Swelling-activated C1 channels support C1- secretion by bovine ciliary epithelium 显示文摘	Do C W Peterson-Yantomo K Civan M M	2006	Invest Ophthalmol Vis Sci2006，47，6：	1
18	Immune-stimulating properties of polysaccharides from Phellodendri cortex (Hwangbek) 显示文摘	Park J I Shim J K Do J W	1999	Glycoconjugate Journal1999，16，：	1
19	Multicast scheduling in cellular data networks 显示文摘	Hyungsuk W Han C Do Y E	2009	IEEE Transactions on Wire- less Communications2009，8，6：	1
20	Management of arteriovenous malformations: a multidisciplinary approach显示文摘	Lee BB Do YS Yakes W	2004	J Vasc Surg2004，39，：	1

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