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| 1 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 2 | Morphology of flame generated soot as determined by thermophoretic sampling显示文摘 | Dobbins R A Megaridis C M | 1987 | Langmuir1987，3，2： | 1 |
| 3 | Introduction: Institutions in the Making: Identity, Power, and the Emergence of New Organizational Forms显示文摘 | WESTENHOLZ A PEDERSEN J DOBBIN F | 2006 | American Behavioral Scientist2006，49，7： | 1 |
| 4 | Comparison of a fractal smoke optics model with light extinction measurements显示文摘 | Dobbins R A Mulholland G W Bryner N P | 1994 | Atmospheric Environment1994，28，5： | 1 |
| 5 | In situ reduction of hexavalent chromium in al- kaline soils enriched with chromite ore processing residue 显示文摘 | Higgins T E Halloran A R Dobbins M E Pittignano Alex J | 1998 | Journal of the Air & Waste Management Associa- tion1998，48，11： | 1 |
| 6 | The effects of biological and social risk factors on special education placement birth weight and maternal education as an example 显示文摘 | HOLLOMON H A DOBBINS D R SCOTT K G | 1998 | Red Dev Disabil1998，19，3： | 1 |
| 7 | Randomised controlled trial of brief intervention with biofeedback and hypnotherapy in patients with refractory irritable bowel syndrome 显示文摘 | Dobbin A Dobbin J Ross SC | 2013 | J R Coll Physicians Edinb2013，43，1： | 1 |
| 8 | Recovery of learning and memory is associated with chromatin remodelling显示文摘 | Fischer A Sananbenesi F Wang X Dobbin M Tsai LH | 2007 | Nature2007，447，7141： | 1 |
| 9 | The effect of extent of resection on recurrence in patients with low grade cerebral hemisphere gliomas 显示文摘 | BERGER M S DELIGANIS A V DOBBINS J | 1994 | Cancer1994，74，6： | 1 |
| 10 | Polycyclic aromatic hydrocarbons in flames, in diesel fuels, and in diesel emissions 显示文摘 | Richard A Dobbins Robert A Fletcher Bruce A Benner Jr | 2006 | Combustion andFlame2006，144，4： | 1 |
| 11 | Effects of pooling mRNA in microarray class comparisons 显示文摘 | Shih J H Michalowska A M Dobbin K | 2004 | Bioinformatics2004，20，18： | 1 |
| 12 | The evolution of soot precursor particles in a diffusion flame 显示文摘 | Dobbins R A Fletcher R A Chang H C | 1998 | Combustion and Flame1998，115，3： | 1 |
| 13 | Endstopping and cur- vature显示文摘 | Dobbins A Zucker S W Cynader M S | 1989 | Vision research1989，29，10： | 1 |
| 14 | Memory orientation and success:Separable neurocognitive components underlying episodic recognition显示文摘 | RICE H J WAGNER A D SCHACTER D L | 2003 | Neuropsychologia2003，41，： | 1 |
| 15 | Digital tomosynthesis of hand joints for arthritis assessment显示文摘 | Duryea J Dobbins JT Lynch J A | 2003 | Med Phys2003，30，： | 1 |
| 16 | The study of the oxidation of uranium by external and diffuse reflectance FTIR spectroscopy using remote-sensing and evacuable cell techniques显示文摘 | POWELL G L DOBBINS A G CRISTY S S | 1994 | SPIE1994，2089，： | 1 |
| 17 | Sex of the parental donor and cellular rejection of renal allografts in children显示文摘 | Kalia A Dobbins JG Brouhard BH | 1988 | Transplantation1988，46，1： | 1 |
| 18 | The inferior parietal lobule and recognition memory:expectancy violation or successful retrieval显示文摘 | O'CONNOR A R HAN S DOBBINS I G | 2010 | J Neurosci2010，30，8： | 1 |
| 19 | Complete genomic sequence of the virulent Salmonella bacteriophage SP6显示文摘 | Dobbins A T George M Jr Basham D A | 2004 | J Bacteriol2004，186，： | 1 |
| 20 | Practical strategies for the clinical implementation of matrix inversion tomosynthesis (MITS) Proc显示文摘 | Godfrey D J Rader A Dobbins JT | 2003 | SPIE2003，5030，： | 1 |
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