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| 1 | 欧洲呼吸病学会/美国胸科学会官方研究共识:自身免疫特征的间质性肺炎显示文摘在临床工作中,有一类患者被诊断为特发性间质性肺炎(idiopathic interstitial pneumonia,IIP),值得注意的是,实际上这类患者与真正的IIP有所差异,他们除了间质性肺炎的表现外,还具备一些或临床特征、或血清学特征、或影像学特征提示其存在潜在的自身免疫性紊乱,但这些表现又不足以达到某些已知结缔组织病(connective tisslie disease,CTD)的既定诊断标准。 | 宋宁 段林 Fischer A Antoniou KM Brown KK | 2015 | 临床荟萃2015，30，10： | 41 |
| 2 | Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock"显示文摘 | Wu YH Fischer DF Kalsbcck A Garidou-Boof ML van der Vliet J van Heijningen C Liu RY Zhou JN Swaab DE | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 3 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 4 | T_3-induced liver AMP-activated protein kinase signaling:Redox dependency and upregulation of downstream targets显示文摘AIM:To investigate the redox dependency and promotion of downstream targets in thyroid hormone(T3)-induced AMP-activated protein kinase(AMPK)signaling as cellular energy sensor to limit metabolic stresses in the liver.METHODS:Fed male Sprague-Dawley rats were given a single ip dose of 0.1 mg T3/kg or T3 vehicle(Na OH0.1 N;controls)and studied at 8 or 24 h after treatment.Separate groups of animals received 500 mg N-acetylcysteine(NAC)/kg or saline ip 30 min prior T3.Measurements included plasma and liver 8-isoprostane and serumβ-hydroxybutyrate levels(ELISA),hepaticlevels of m RNAs(q PCR),proteins(Western blot),and phosphorylated AMPK(ELISA).RESULTS:T3 upregulates AMPK signaling,including the upstream kinases Ca2+-calmodulin-dependent protein kinase kinase-βand transforming growth factor-β-activated kinase-1,with T3-induced reactive oxygen species having a causal role due to its suppression by pretreatment with the antioxidant NAC.Accordingly,AMPK targets acetyl-Co A carboxylase and cyclic AMP response element binding protein are phosphorylated,with the concomitant carnitine palmitoyltransferase-1α(CPT-1α)activation and higher expression of peroxisome proliferator-activated receptor-γco-activator-1αand that of the fatty acid oxidation(FAO)-related enzymes CPT-1α,acyl-Co A oxidase 1,and acylCo A thioesterase 2.Under these conditions,T3 induced a significant increase in the serum levels ofβ-hydroxybutyrate,a surrogate marker for hepatic FAO.CONCLUSION:T3 administration activates liver AMPK signaling in a redox-dependent manner,leading to FAO enhancement as evidenced by the consequent ketogenic response,which may constitute a key molecular mechanism regulating energy dynamics to support T3preconditioning against ischemia-reperfusion injury. | Luis A Videla Virginia Fernández Pamela Cornejo Romina Vargas Paula Morales Juan Ceballo Alvaro Fischer Nicolás Escudero Oscar Escobar | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 5 | Plant Productivity in the Arid and Semiarid Zones显示文摘 | R A Fischer N C Turner | 1978 | Annual Review of Plant Physiology1978，，： | 3 |
| 6 | National Forest Inventories capture the multifunctionality of managed forests in Germany显示文摘Background:Forests perform various important ecosystem functions that contribute to ecosystem services.In many parts of the world,forest management has shifted from a focus on timber production to multi-purpose forestry,combining timber production with the supply of other forest ecosystem services.However,it is unclear which forest types provide which ecosystem services and to what extent forests primarily managed for timber already supply multiple ecosystem services.Based on a comprehensive dataset collected across 150 forest plots in three regions differing in management intensity and species composition,we develop models to predict the potential supply of 13 ecosystem services.We use those models to assess the level of multifunctionality of managed forests at the national level using national forest inventory data.Results:Looking at the potential supply of ecosystem services,we found trade-offs(e.g.between both bark beetle control or dung decomposition and both productivity or soil carbon stocks)as well as synergies(e.g.for temperature regulation,carbon storage and culturally interesting plants)across the 53 most dominant forest types in Germany.No single forest type provided all ecosystem services equally.Some ecosystem services showed comparable levels across forest types(e.g.decomposition or richness of saprotrophs),while others varied strongly,depending on forest structural attributes(e.g.phosphorous availability or cover of edible plants)or tree species composition(e.g.potential nitrification activity).Variability in potential supply of ecosystem services was only to a lesser extent driven by environmental conditions.However,the geographic variation in ecosystem function supply across Germany was closely linked with the distribution of main tree species.Conclusions:Our results show that forest multifunctionality is limited to subsets of ecosystem services.The importance of tree species composition highlights that a lack of multifunctionality at the stand level can be compensated by managing forests at the landscape level,when stands of complementary forest types are combined.These results imply that multi-purpose forestry should be based on a variety of forest types requiring coordinated planning across larger spatial scales. | Nadja K.Simons María R.Felipe-Lucia Peter Schall Christian Ammer Jürgen Bauhus Nico Blüthgen Steffen Boch François Buscot Markus Fischer Kezia Goldmann Martin M.Gossner Falk Hänsel Kirsten Jung Peter Manning Thomas Nauss Yvonne Oelmann Rodica Pena Andrea Polle Swen C.Renner Michael Schloter Ingo Schöning Ernst-Detlef Schulze Emily F.Solly Elisabeth Sorkau Barbara Stempfhuber Tesfaye Wubet Jörg Müller Sebastian Seibold Wolfgang W.Weisser | 2021 | Forest Ecosystems2021，8，1： | 2 |
| 7 | Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction显示文摘 | Jose A Melendez Vittoria Arslan Mary E Fischer David Wuest William R Jarnagin Yuman Fong Leslie H Blumgart | 1998 | Journal of the American College of Surgeons1998，，6： | 2 |
| 8 | Microfiltration of colloids and natural organic matter显示文摘 | Schiafer A I Chwicker U S Fischer M M | 2000 | J Membr Sci2000，171，： | 2 |
| 9 | Recovery of learning and memory is associated with chromatin remodelling显示文摘 | Fischer A Sananbenesi F Wang X | | 0，，： | 2 |
| 10 | 作为后牙固定义齿支架材料的新型氧化铈稳定四方晶相氧化锆/氧化铝纳米复合体——修复后1年前瞻性病例系列的初步结果显示文摘目的:检验饰面瓷后.氧化铈稳定四方晶相氧化锆/氧化铝纳米复合体(Ce—TZP/A-纳米复合体)做为后牙三单位固定桥(FDPs)支架的临床效果。材料和方法:将单个前磨牙或磨牙缺失需要单个固定桥修复的8名患者纳入病例研究系列。使用CAD/CAM系统(Hint—Eis)制作8个Ce—TZP/A-纳米复合体FDP支架.在支架表面烧制氧化锆饰面瓷(Vintage ZR.Shofu),树脂粘结剂粘结FDPs。粘结后2周、3个月、6个月、12个月选择USPHS标准对修复体进行评价。比较基牙(实验组)与对侧未治疗牙(对照组)的菌斑指数、探诊出血、牙周袋深度等生物学评价指标。在粘结后即刻以及6个月、12个月随访时进行X线检查。对数据进行统计分析。结果:8个被检测FDPs的平均观测期为128-4-11个月。FDPs的保存率为100%。此外,未见FDPs在技术或生物学方面的并发症。实验组PCR为0.1±01、BOP 0.2±0.2、PPD 2.6±0.8。对照组PCR为0.2±0.2、BOP 0.1±0.1、PPD2.6±0.6。两组间各项均值无显著性差异。结论:修复治疗一年后的结果显示.Ce—TZP/A复合体是一种可靠的支架材料。确认上述结论还需要纳入更多的患者.并进行长期的临床随机对照观察实验。 | Philipp A Fischer J Hammerle CHF Sailer I 王琳琳(译) 邵龙泉(审) | 2010 | 中国口腔医学继续教育杂志2010，，6： | 2 |
| 11 | Cyclosporine metabolism in human liver: Identification of a cytochrome P-450 Ⅲ gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs显示文摘 | Kronbach T Fischer V Meyer U A | | Clin Pharmacol Th0，，： | 2 |
| 12 | Spatial knowledge spillover and university research : evidence from austria 显示文摘 | Fischer M M Varga A | 2003 | The Annals of Regional Science2003，，37： | 1 |
| 13 | Stem cell division is regulated by the microRNA pathway显示文摘 | HATFIELD S D SHCHERBATA H R FISCHER K A | 2005 | Nature2005，435，7044： | 1 |
| 14 | Two independent triggers for the Indian Ocean dipole/zonal mode in a coupled GCM显示文摘 | FISCHER A S TERRAY P GUILYARDI E | 2005 | J Climate2005，18，17： | 1 |
| 15 | Respiratory sequelae of viral diseases: from diagnosis to treatment 显示文摘 | Teper A Fischer GB Jones MH | 2002 | J Pediatr (Rio J)2002，78，2： | 1 |
| 16 | Neural regulation of airway smooth muscle tone显示文摘 | Canning B J Fischer A | 2001 | Respir Physiol2001，125，12： | 1 |
| 17 | Inducible aluminum re- sistance of Acidiphilium cryptum and aluminum tolerance of other acido- philic bacteria显示文摘 | FISCHER J QUENTMEIER A GANSEL S | 2002 | Archives of Microbiology2002，178，6： | 1 |
| 18 | Project-modelling inAEC to integrate design and construction显示文摘 | Luiten G T Tolman F P Fischer M A | 1998 | Computers inIndustry1998，，35： | 1 |
| 19 | Clinical responsesin patients with advanced colorectal cancer to a dendritic cell basedvaccine显示文摘 | Burgdorf SK Fischer A Myschetzky PS | 2008 | Oncol Rep2008，20，6： | 1 |
| 20 | Method for extracting and thickening a mid-surface of a 3D thin object represented in NURBS显示文摘 | Fischer A Wang K K | 1997 | J Manufacturing Science and Engineering1997，119，4： | 1 |
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