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| 1 | Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1,NF-IL6 and NF-kappa B) which are involved in IL-6 regulation显示文摘 | Dokter WHA Koopmans SB Vellenga E | 1996 | Leukemia1996，10，8： | 1 |
| 2 | Deletion of the WNT target and cancer stem cell mar-ker CD44 in Ape( Min/+ ) mice atten- uates intestinal tumorigenesis显示文摘 | Zeilstra J Joosten SP Dokter M | 2008 | Cancer Res2008，68，10： | 1 |
| 3 | Extracellularregulated kinase 1/2,Jun N - terminal kinase,and c - Jun are involved in NF - kappa B - dependent IL- 6 expression in human monocytes显示文摘 | Tuyt LM Dokter WH Birkenkamp K | 1999 | J Immunol1999，162，8： | 1 |
| 4 | A dual function for p38 MAP kinase in hematopoietic cells:involvement in apoptosis and cell activation显示文摘 | Birkenkamp K U Dokter W H Esselink M T | 1999 | Leukemia1999，13，7： | 1 |
| 5 | Interleukin -6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac - 1 and the kinase SEK-1/MKK - 4 as signal transduction components显示文摘 | SCHURINGA J J JONK L J DOKTER W H | 2000 | Biochem J2000，347，1： | 1 |
| 6 | The hydrothermal synthesis of silicate - an in situ small-angle neutron scattering study显示文摘 | Dokter W H Beelen T P M Van Garderen H F | 1994 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1994，85，： | 1 |
| 7 | Simultaneous monitoring of amorphous and crystalline phases in silicate precursor gels:an in situ hydrothermal and times-resolved small-and wide-angle X - ray scattering study显示文摘 | Dokter W H Beelen T P M Van Garderen HF | 1994 | Appl Cryst1994，27，： | 1 |
| 8 | Interleukin-6-induced STAT3 transaetivation and Ser727 phosphorylation involves Vav,Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components显示文摘 | Schurinqa JJ Jonk LJ Dokter WH | 2000 | Bioehm J2000，347，： | 1 |
| 9 | Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav,Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components显示文摘 | Schuringa JJ Jonk LJ Dokter WH | 2000 | Biochem J2000，347，： | 1 |
| 10 | Interaction between MTHFR 677C>;T and periconceptional folic acid supplementation in the risk of Hypospadias显示文摘 | Dokter EM van Rooij IA Wijers CH | 2016 | Birth Defects Res A Clin Mol Teratol2016，10，16： | 1 |
| 11 | Neurogenesis within the adult hippocampus under physiological conditions and in depression显示文摘Adult neurogenesis can only be observed in some specific brain regions. One of these areas is the dentate gyrus of the hippocampal formation. The progenitor cells located in the subgranular layer of the dentate gyrus proliferate, differentiate, and give rise to young neurons that can become integrated into existing neuronal circuits. Under physiological conditions, hippocampal neurogenesis is linked to hippocampal-dependent learning, whereas deficits in adult hippocampal neurogenesis have been shown to correlate with disturbances in spatial learning and memory. This review summarizes the phenomenon of adult hippocampal neurogenesis and the use of suitable markers for the investigation of adult hippocampal neurogenesis. In addition, we focused on the disturbances in neurogenesis that can be seen in depression. Interestingly, several antidepressants have been found to be capable of increasing the rate of hippocampal neurogenesis. Based on that, it can be speculated that factors, which directly or indirectly increase the rate of hippocampal neurogenesis, may be helpful in the treatment of depression. | Martin Dokter Oliver von Bohlen und Halbach | 2012 | Neural Regeneration Research2012，7，7： | 1 |
| 12 | The hydrothermal synthesis of silicate--an in situ smallangle neutron scattering study显示文摘 | DOKTER W H BEELEN T P M VAN GARDEREN H F | 1994 | Colloids Surf A: Physicothem Eng Aspects1994，85，： | 1 |
| 13 | Selecting highly af- fine and well-expressed TCRs for gene therapy of melanoma 显示文摘 | Jorritsma A Gomez-Eerland R Dokter M | 2007 | Blood2007，110，10： | 1 |
| 14 | Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes显示文摘 | Dokter W H Birkenkamp K | 1999 | J Immunol1999，162，8： | 1 |
| 15 | Homogeneous versus heterogeneous zeolite nucleation显示文摘 | DOKTER W H Van GARDEREN H F | 1995 | Angew Chem (Int Ed Engl)1995，34，： | 1 |
| 16 | Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-l,NF-IL6 and NF-kappa B) which are involved in IL-6 regulation显示文摘 | Dokter WH Koopmans SB Vellenga E | 1996 | Leukemia1996，10，8： | 1 |
| 17 | Short-term vitamin D3 supplementation lowers plasma renin activity in patients with stable chronic heart failure: An open-label, blinded end point, randomized prospective trial (VitD-CHF trial)显示文摘 | Nicolas F. Schroten Willem P.T. Ruifrok Lennaert Kleijn Martin M. Dokter Herman H. Silljé Hiddo J. Lambers Heerspink Stephan J.L. Bakker Ido P. Kema Wiek H. van Gilst Dirk J. van Veldhuisen Hans L. Hillege Rudolf A. de Boer | 2013 | American Heart Journal2013，，2： | 1 |
| 18 | Functional outcome after burns: A review显示文摘 | M.E. van Baar M.L. Essink-Bot I.M.M.H. Oen J. Dokter H. Boxma E.F. van Beeck | 2005 | Burns2005，，1： | 1 |
| 19 | Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components显示文摘 | Jonk L J Dokter W H | 2000 | Biochem J2000，347，： | 1 |
| 20 | Burns in the elderly:a nationwide study on management and clinical outcomes显示文摘Background:In modern-day burn care,advanced age remains an important predictor for mortality among burn victims.In this study,we compared the complete treatment trajectory(including prehospital and surgical treatment)and the outcomes between an elderly burn population and a younger adult burn population.Methods:In this nationwide study,data from the Dutch Burn Repository were used.This is a uniform national registration for Dutch specialized burn care.All adult patients that were admitted to one of the three Dutch burn centres from the period 2009 to 2015 were included in the analysis.Burn patients were considered as elderly when≥65 years of age,and were then further subdivided into three age categories:65–74,75–85 and 85+years.Younger adults in the age category 18–64 years were used as the reference group.Surgical managementwas studied comprehensively and included timing of surgery,the number of procedures and details on the surgical technique,especially the technique used for debridement and the grafting technique that was applied.For the comparison of clinical outcome,the following parameters were included:mortality,wound infections,length of stay/TBSA(total body surface area)burned,discharge disposition and secondary reconstructions.Results:During the study period,3155 adult patients were included(elderly,n=505).Burn severity,reflected by the median TBSA,varied between 3.2–4.0%and was comparable,but aetiology and pre-hospital care were different between elderly and the younger adult reference group.Surgical treatment was initiated significantly faster in elderly burn patients(p<0.001).Less selective techniques for surgical debridement were used in the elderly burns patients(hydrosurgery,42.0%vs 23.5–22.6%),and on the other hand more avulsion(5.3%vs 7.3–17.6%)and primary wound closure(6.7%vs 24.5%).The most frequently used grafting technique was meshed skin grafts(79.2–88.6%);this was not related to age.Mortality increased rapidly with a higher age and showed a high peak in the 85+category(23.8%).Furthermore,considerable differences were found in hospital discharge disposition between the elderly and the reference group.Conclusions:In conclusion,elderly burn patients who require specialized burn care are vulnerable and medically challenging.Differences in aetiology,comorbidity,physiology and the management prior to admission possibly affect the initial surgical management and result in significantly worse outcomes in elderly.Elderly patients need optimal,timely and specialized burn care to enhance survival after burn injuries. | Harold Goei Margriet E.van Baar Jan Dokter J Vloemans Gerard I.J.M.Beerthuizen Esther Middelkoop Kees H.van der Vlies the Dutch Burn Repository group | 2020 | Burns & Trauma2020，8，1： | 0 |
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