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| 1 | Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound显示文摘AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-positive cells in 10 high power fields of healthy mucosa: 1 ± 1.2 vs 42 d after DSS start: 2.4 ± 1.6 vs 84 d after DSS start: 3.5 ± 1.3, P < 0.01). CONCLUSION Molecularly targeted CEUS is a highly specific and noninvasive imaging modality, which characterizes murine intestinal inflammation and carcinogenesis in vivo. | Markus Brückner Jan Heidemann Tobias M Nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth | 2017 | World Journal of Gastroenterology2017，23，16： | 4 |
| 2 | Integrated colloidal quantum dot photodetectors with color-tunable plasmonic nanofocusing lenses显示文摘High-sensitivity photodetection is at the heart of many optoelectronic applications,including spectroscopy,imaging,surveillance,remote sensing and medical diagnostics.Achieving the highest possible sensitivity for a given photodetector technology requires the development of ultra-small-footprint detectors,as the noise sources scale with the area of the detector.This must be accomplished while sacrificing neither the optically active area of the detector nor its responsivity.Currently,such designs are based on diffraction-limited approaches using optical lenses.Here,we employ a plasmonic flat-lens bull’s eye structure(BES)to concentrate and focus light into a nanoscale colloidal quantum dot(CQD)photodetector.The plasmonic lenses function as nanofocusing resonant structures that simultaneously offer color selectivity and enhanced sensitivity.Herein,we demonstrate the first CQD photodetector with a nanoscale footprint,the optically active area of which is determined by the BES;this detector represents an exciting opportunity for high-sensitivity sensing. | Silke L Diedenhofen Dominik Kufer Tania Lasanta Gerasimos Konstantatos | 2015 | Light(Science & Applications)2015，4，1： | 3 |
| 3 | Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature显示文摘AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral diets.METHODS:We conducted a comprehensive literature search of Pubmed and Embase databases.We manually screened articles that examined nutritional and health outcomes(e.g.,growth,disease activity,gastrointestinal impairment,mortality,and economic impact)among various patient groups receiving semi-elemental diets.This review focused on full-text articles of randomized controlled clinical trials and other intervention studies,but pertinent abstracts and case studies were also included.Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population in this systematic review.RESULTS:Results pertaining primarily to tolerance,digestion,and absorption were summarized for each patient population.The efficacy of semi-elemental whey hydrolyzed protein(WHP)diet have been reported in various nutritionally high risk patient populations including-Crohn’s disease,short bowel syndrome,acute and chronic pancreatitis,cerebral palsy,cystic fibrosis,cerebrovascular accidents,human immunodeficiency virus,critically ill,and geriatrics.Collectively,the evidence from the medical literature indicates that feeding with a semi-elemental diet performs as well or better than parenteral or amino acid based diets in terms of toler-ance,digestion,and nutrient assimilation measures across various disease conditions.CONCLUSION:Based on this comprehensive review of the literature,patient populations who have difficulty digesting or absorbing standard diets may be able to achieve improved health and nutritional outcomes through the use of semi-elemental WHP diets. | Dominik D Alexander Lauren C Bylsma Laura Elkayam Douglas L Nguyen | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 3 |
| 4 | Analysis of the immunological microenvironment at the tumor site in patients with non-small cell lung cancer显示文摘 | Rui Li Dominik Rüttinger Rong Li Lü-Sheng Si Yi-Li Wang | 2003 | Langenbeck’s Archives of Surgery2003，，6： | 1 |
| 5 | Native bacterial endophytes promote host growth in aspecies-specific manner; phytohormone manipulations do not result in common growth responses显示文摘 | HOANG H L DOMINIK D SCHMIDT I T | 2008 | PLos ONE2008，3，7： | 1 |
| 6 | High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson's disease显示文摘 | Dominik H Purnat TD Jason L | 2007 | J Biol Chem2007，282，： | 1 |
| 7 | Virtual lead user communi- ties: drivers of knowledge creation for innovation 显示文摘 | DOMINIK M ANNOUK L | 2012 | Re- search Policy2012，41，1： | 1 |
| 8 | Arabidopsis plant homeodomain finger proteins operate downstream of auxin accumulation in specifying the vascula- ture and primary root meristem显示文摘 | CAROLE L T DOMINIK S EMMANUELLE M B | 2009 | The Plant Journal2009，59，3： | 1 |
| 9 | U tility of MR arthrography in the diagnosis of adhesive eapsulitis 显示文摘 | Geoffrey L Manton Schweitzer M E Dominik Weishaupt | 2001 | Skeletal Radiology2001，30，6： | 1 |
| 10 | Blood vessels and lymphatics in calcific aortic stenosis--in support of its inflammatory pathogenesis显示文摘 | Steiner I Krbal L Dominik J | 2010 | Cesk Patol2010，46，2： | 1 |
| 11 | The origin of crystalline silicates in the Herbig Be star HD100546 and in comet Hale-Bopp显示文摘 | Bouwman J de Koter A Dominik C Waters L B F M | 2003 | Astronomy and Astrophysics2003，401，： | 1 |
| 12 | A novel and simple cell-based detection system with a collagen-encapsulated B-lymphocyte cell line as a biosensor for rapid detection of pathogens and toxins 显示文摘 | Pratik B Dominik L Joseph P R | 2008 | Laboratory Investigation2008，88，： | 1 |
| 13 | A gabor filter-based approach to leaf vein extraction and cultivar classification 显示文摘 | Dominik L M Gerrit A S | 2013 | Lecture Notes in Computer Science2013，7972，： | 1 |
| 14 | Reduced Storageand Balancing Needs in A Fully Renewable European Power System with Excess Wind and Solar Power Generation 显示文摘 | DOMINIK H MARTIN G BREMEN L V | 2011 | Renewable Energy2011，，36： | 1 |
| 15 | Hepatocyte GP73 expression in Wilson disease显示文摘 | WRIGHT L M DOMINIK H SVETLANA L | 2009 | J Hepatol2009，51，3： | 1 |
| 16 | Few genes are associated with the capability of pancreatic ductal adenocarcinomacells to grow in the liver of nude rats显示文摘 | Ergül Eyol Ahmed Murtaga Maria Zhivkova-Galunska Rania Georges Michael Zepp Dominik Djandji J?rg Kleeff Martin Berger Hassan Adwan | 2012 | Oncology Reports2012，，6： | 1 |
| 17 | Pain perception in depression:relationships to symptomatology and naloxone-sensitive mechanisms显示文摘 | Stefan L Stephan R Dominik S | 1994 | Psychosomatic Medicine1994，56，： | 1 |
| 18 | Chromium ( Ⅵ ) is more toxic than chromium ( Ⅲ ) to freshwater algae: a paradigm to revise 显示文摘 | Vignati D A L Dominik J Beye M L | 2010 | Eeotoxieology and Environmental Safety2010，73，： | 1 |
| 19 | Defective cellular localization of mutant ATP7B in wilson's disease patients and hepatom cell lines显示文摘 | Dominik H Michael H Svetlana L | 2003 | Gastroenterology2003，124，： | 1 |
| 20 | Absorptionofsulfur dioxide in N- formylmorpholine: investigations of the kinetics of the liquid phase reaction显示文摘 | Dominik N Richard D K Hans-Gunther L | 2002 | Chemical EngineeringScience2002，57，： | 1 |
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