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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | The Quality of Life (QOL) Research Movement: Past, Present, and Future显示文摘 | Sirgy M A C michalos A L Ferriss R Easterlin Donald Patrick William Pavot | 2006 | Social Indicators Research2006，76，： | 1 |
| 4 | Periphyton growth on submerged artificial substrate as a predictor of phytoplankton response to nutrient enrichment显示文摘 | Smoot J C Donald E L Michella L | 1998 | Journal of Microbiological Methods1998，，32： | 1 |
| 5 | Heart Disease and Stroke Statistics-2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee 显示文摘 | DONALD L J ROBERT A MERCEDES C | 2009 | Circulation2009，119，3： | 1 |
| 6 | De- termination of undegradable intake protein digestibility of forages using the mobile nylon bag technique 显示文摘 | HAUGEN H L IVAN S K MAC DONALD J C | 2006 | J Anita Sci2006，84，： | 1 |
| 7 | New Techniques for Suppression of Automobile Ignition Noise 显示文摘 | Richard A Shepherd James C Gaddie Donald L Nielson | 1976 | IEEE Transactions on Vehicular Technology1976，25，1： | 1 |
| 8 | Indicators of human health in ecosystems:what do we measure显示文摘 | Donald C Cole John Eyles Brian L Gibson | 1998 | The Science of the Total Environment1998，224，： | 1 |
| 9 | Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injury显示文摘 | Brody D L Mac Donald C Kessens C C | 2007 | Journal of neurotrauma2007，24，4： | 1 |
| 10 | Conjunctival rotation autograft for pterygium: an alternative to conjunctival autografting显示文摘 | Jap A Chan C Lim L Donald TH | 1999 | Ophthalmology1999，106，： | 1 |
| 11 | Diffusion tensor imaging reliably detects experimental traumatic axonal injury and indicates approximate time of injury显示文摘 | Mac Donald C L Dikranian K Bayly P | 2007 | J Neurosci2007，27，11： | 1 |
| 12 | Distribution of the Bottom Simulating Reflector in the Offshore Taiwan Collision Zone 显示文摘 | Chi W C Donald L R Liu C S | 1998 | TAO1998，9，4： | 1 |
| 13 | Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models 显示文摘 | Carios Portera-Cailliau John C Hedreen Donald L Price | 1995 | J Neurosci1995，15，5： | 1 |
| 14 | Nitrogen mineralization and crop uptake from surface-applied leaves of green manure species on a tropical volcanicash soil显示文摘 | Donald C L | 2002 | Biol Fertil Soils2002，36，2： | 1 |
| 15 | Redox reaction involving hydrocarbons and mineral oxidant's: A mechanism for significant porosity enhancement in sandstones 显示文摘 | Surdam R C Crossey L J MacGowan Donald B | 1993 | AAPG Bull1993，77，9： | 1 |
| 16 | Bandwidth Characterization in the Mieropositioning of Ionic Polymer Actuators 显示文摘 | Kothfra C Donald T L | 2005 | Journal of Intelligent Material Systems and Structures2005，16，1： | 1 |
| 17 | Explaining the Premiums Paid for Large Acquisitions:Evidence of CEO Hubris显示文摘 | Hayward L A M Donald C H | 1997 | Adminis- trative Science Quarterly1997，，42： | 1 |
| 18 | Arctic sea ice extents,areas,and trends显示文摘 | Claire L P Donald J C Gloersen P | 1999 | J Geophys Res1999，104，20： | 1 |
| 19 | Characterization of the solution conformations of unbound and Tat peptide-bound forms of HIV-1 TAR RNA显示文摘 | Katherine S L Donald M C | 1999 | Biochem1999，38，10： | 1 |
| 20 | Age-dependent associations between sleep-disordered breathing and hypert-ension显示文摘 | Donald C Haas Gregory L Foster F Javier Nieto | 2005 | Circulation2005，111，： | 1 |
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