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| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 3 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 4 | The Quality of Life (QOL) Research Movement: Past, Present, and Future显示文摘 | Sirgy M A C michalos A L Ferriss R Easterlin Donald Patrick William Pavot | 2006 | Social Indicators Research2006，76，： | 1 |
| 5 | Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins显示文摘 | David R Borchelt Tamara Ratovitski Judy van Lare Michael K Lee Vicki Gonzales Nancy A Jenkins Neal G Copeland Donald L Price Sangram S Sisodia | 1997 | Neuron1997，，4： | 1 |
| 6 | The role of sandwich holography in ICF 显示文摘 | Theodore R Pattinson Donald L | 1989 | J Vac Sci Technol1989，7，3： | 1 |
| 7 | The capsaicinoid: their separation, synthesis and mutagenicith 显示文摘 | Peter M G Donald L N Pam J R | 1988 | J Org Chem1988，53，5： | 1 |
| 8 | Are corporate governance and bank monitoring substitutes: Evidence from the perceived value of bank loans显示文摘 | Steven S Byers L Paige Fields Donald R Fraser | 2008 | Journal of Corporate Finance2008，14，： | 1 |
| 9 | The immobilization of high level radioactive wastes using ceramics and glasses显示文摘 | DONALD W METCALFE B L TAYLOR R N J | 1997 | Journal of Materials Science1997，32，22： | 1 |
| 10 | Methods for Researching Gear Whine in Automotive TransaxIes显示文摘 | ASHLEY L D DONALD R H | 1997 | SAE1997，，1： | 1 |
| 11 | Review: The immobilization of high level radioactive wastes using ceramics and glasses显示文摘 | DONALD I W METCALFE B L TAYLOR R N J | 1997 | J Mater Sci1997，，32： | 1 |
| 12 | Toward a model of eye movement control in reading显示文摘 | Erik D R Alexander P Donald L Fisher K R | | 0，，105： | 1 |
| 13 | Distribution of the Bottom Simulating Reflector in the Offshore Taiwan Collision Zone 显示文摘 | Chi W C Donald L R Liu C S | 1998 | TAO1998，9，4： | 1 |
| 14 | Arsenate and chromate retention mechanisms on goethite 2 kinetic evaluation using a pressure-jump relaxation technique 显示文摘 | Paul R G Matthew E Donald L S et ol | 1997 | Environ Sci Technol1997，31，2： | 1 |
| 15 | Software Implementation of a PN Spread Spectrum Receiver to Accommodate Dynamics显示文摘 | Charles R Cahn Donald K Leimer Charles L Marsh | 1977 | IEEE Transactions on Communications1977，25，8： | 1 |
| 16 | Enzyme-linked immunosorbent assay for the pyrethroid permethrin显示文摘 | GUOMIN S WHITNEY R L DONALD W S | 2000 | Journal of Agricultural and Food Chemistry2000，48，： | 1 |
| 17 | More than taking the heat: crops and global change显示文摘 | Stephen P L Donald R O | 2010 | Curr Opin Plant Biol2010，13，3： | 1 |
| 18 | Chemistry and biology of hop flavonoids显示文摘 | Jan F Stevens Cristobal L Miranda Donald R Buhler | 1998 | J Am Soc Brew Chem1998，，56： | 1 |
| 19 | A modified screen for the detection of cell wall-acting antifungal compounds 显示文摘 | Donald R K Margaret H L | 1986 | d Antibiot1986，39，11： | 1 |
| 20 | Redox reaction involving hydrocarbons and mineral oxidant's: A mechanism for significant porosity enhancement in sandstones 显示文摘 | Surdam R C Crossey L J MacGowan Donald B | 1993 | AAPG Bull1993，77，9： | 1 |
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