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| 1 | Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator. | Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 2 | Producing deep UV-LEDs in high-yield MOVPE by improving AlN crystal quality with sputtered AlN nucleation layer显示文摘High-quality AlN layers with low-density threading dislocations are indispensable for high-efficiency deep ultraviolet light-emitting diodes(UV-LEDs). In this work, a high-temperature AlN epitaxial layer was grown on sputtered AlN layer(used as nucleation layer, SNL) by a high-yield industrial metalorganic vapor phase epitaxy(MOVPE). The full width half maximum(FWHM) of the rocking curve shows that the AlN epitaxial layer with SNL has good crystal quality. Furthermore, the relationships between the thickness of SNL and the FWHM values of(002) and(102) peaks were also studied. Finally, utilizing an SNL to enhance the quality of the epitaxial layer, deep UV-LEDs at 282 nm were successfully realized on sapphire substrate by the high-yield industrial MOVPE. The light-output power(LOP) of a deep UV-LED reaches 1.65 mW at 20 mA with external quantum efficiency of 1.87%. In addition, the saturation LOP of the deep UV-LED is 4.31 mW at an injection current of 60 mA. Hence, our studies supply a possible process to grow commercial deep UV-LEDs in high throughput industrial MOVPE, which can increase yield, at lower cost. | Zejie Du Ruifei Duan Tongbo Wei Shuo Zhang Junxi Wang Xiaoyan Yi Yiping Zeng Junxue Ran Jinmin Li Boyu Dong | 2017 | Journal of Semiconductors2017，38，11： | 1 |
| 3 | A new concept - fotmation of permeating layers from nonactive antiwear additive显示文摘 | Dong Junxue Chen Guoxu | 1994 | Lubr Eag1994，50，1： | 1 |
| 4 | VirtCO:Joint Coflow Scheduling and Virtual Machine Placement in Cloud Data Centers显示文摘Cloud data centers, such as Amazon EC2, host myriad big data applications using Virtual Machines(VMs). As these applications are communication-intensive, optimizing network transfer between VMs is critical to the performance of these applications and network utilization of data centers. Previous studies have addressed this issue by scheduling network flows with coflow semantics or optimizing VM placement with traffic considerations.However, coflow scheduling and VM placement have been conducted orthogonally. In fact, these two mechanisms are mutually dependent, and optimizing these two complementary degrees of freedom independently turns out to be suboptimal. In this paper, we present VirtCO, a practical framework that jointly schedules coflows and places VMs ahead of VM launch to optimize the overall performance of data center applications. We model the joint coflow scheduling and VM placement optimization problem, and propose effective heuristics for solving it. We further implement VirtCO with OpenStack and deploy it in a testbed environment. Extensive evaluation of real-world traces shows that compared with state-of-the-art solutions, VirtCO greatly reduces the average coflow completion time by up to 36.5%. This new framework is also compatible with and readily deployable within existing data center architectures. | Dian Shen Junzhou Luo Fang Dong Junxue Zhang | 2019 | Tsinghua Science and Technology2019，24，5： | 1 |
| 5 | Efflcient machining of a complex blisk channel using a disc cutter显示文摘For rough machining of a complex narrow cavity,e.g.,a complex blisk channel on an aero-engine,the typically used cutting tools are the slender cylindrical cutter and conical cutter.Nevertheless,as neither of the two is particularly suited for rough machining,wherein the main purpose is to remove a large volume as quickly as possible,the machining efficiency is low,especially when the part materials are of hard-to-cut types(e.g.,Titanium-alloy)for which it often takes days to rough machine a blisk.Fortunately,disc machining provides a new and efficient roughing solution,since a disc cutter with a large radius enables a much larger cutting speed and thus a larger material removal rate.However,due to the large radius of the disc cutter,its potential collision with narrow and twisted channels becomes a serious concern.In this paper,we propose a novel twophase approach for efficiently machining a complex narrow cavity workpiece using a disc-shaped cutter,i.e.,3+2-axis disc-slotting of the channel by multiple layers(rough machining)+five-axis disc-milling of the freeform channel side surfaces(semi-finish machining).Both simulation and physical cutting experiments are conducted to assess the effectiveness and advantages of the proposed method.The experimental results show that,with respect to a same cusp-height threshold on the channel side surfaces,the total machining time of the tested part by the proposed method is about only 36%of that by the conventional approach of plunging-milling(for roughing)plus milling by a slender cylindrical cutter(for semi-finishing). | Xiangyu LI Zhaoyu LI Dong HE Junxue REN Qian FENG Kai TANG | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
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