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| 1 | Natural history of covert hepatic encephalopathy: An observational study of 366 cirrhotic patients显示文摘AIM To explore the natural history of covert hepatic encephalopathy(CHE) in absence of medication intervention.METHODS Consecutive outpatient cirrhotic patients in a Chinese tertiary care hospital were enrolled and evaluated for CHE diagnosis. They were followed up for a mean of 11.2 ± 1.3 mo. Time to the first cirrhosis-related complications requiring hospitalization, including overt HE(OHE), resolution of CHE and death/transplantation, were compared between CHE and no-CHE patients. Predictors for complication(s) and death/transplantation were also analyzed.RESULTS A total of 366 patients(age: 47.2 ± 8.6 years, male: 73.0%) were enrolled. CHE was identified in 131 patients(35.8%). CHE patients had higher rates of death and incidence of complications requiring hospitalization, including OHE, compared to unimpaired patients. Moreover, 17.6% of CHE patients developed OHE, 42.0% suffered persistent CHE, and 19.8% of CHE spontaneously resolved. In CHE patients, serum albumin < 30 g/L(HR = 5.22, P = 0.03) was the sole predictor for developing OHE, and blood creatinine > 133 μmol/L(HR = 4.75, P = 0.036) predicted mortality. Child-Pugh B/C(HR = 0.084, P < 0.001) and OHE history(HR = 0.15, P = 0.014) were predictors of spontaneous resolution of CHE.CONCLUSION CHE exacerbates, persists or resolves without medication intervention in clinically stable cirrhosis. Triage of patients based on these predictors will allow for more cost-effect management of CHE. | An-Jiang Wang A-Ping Peng Bi-Min Li Na Gan Li Pei Xue-Lian Zheng Jun-Bo Hong Hai-Ying Xiao Jia-Wei Zhong Xuan Zhu | 2017 | World Journal of Gastroenterology2017，23，34： | 22 |
| 2 | Rapid and sensitive detection of pesticides by surface-enhanced Raman spectroscopy technique based on glycidyl methacrylate-ethylene dimethacrylate(GMA-EDMA) porous material显示文摘A novel method of fast and sensitive SERS detection using GMA-EDMA porous material combined with a miniature device was reported in this study.A100μL solution containing sample,silver colloid and NaCl was evenly mixed to ensure the sample molecules would adsorb onto silver nanoparticles.Then the mixture was added onto the porous material surface slowly,so that the aggregation of silver colloid would stay on the surface while the liquid components would flow away.This technology can improve the sensitivity of SERS detection.By this method,two pesticides tricyclazole and paraquat were successfully detected at concentrations of 5×10^(-3) mg/L and 1×10^(-3) mg/L,respectively. | Qing-Qing Li Yi-Ping Du Ying Xu Xuan Wang Shi-Qian Ma Jin-Pei Geng Peng Cao Tao Sui | 2013 | Chinese Chemical Letters2013，24，4： | 10 |
| 3 | The resurgent landscape of xenotransplantation of pig organs in nonhuman primates显示文摘Organ shortage is a major bottleneck in allotransplantation and causes many wait-listed patients to die or become too sick for transplantation.Genetically engineered pigs have been discussed as a potential alternative to allogeneic donor organs.Although xenotransplantation of pig-derived organs in nonhuman primates(NHPs)has shown sequential advances in recent years,there are still underlying problems that need to be completely addressed before clinical applications,including(i)acute humoral xenograft rejection;(ii)acute cellular rejection;(iii)dysregulation of coagulation and inflammation;(iv)physiological incompatibility;and(v)cross-species infection.Moreover,various genetic modifications to the pig donor need to be fully characterized,with the aim of identifying the ideal transgene combination for upcoming clinical trials.In addition,suitable pretransplant screening methods need to be confirmed for optimal donor-recipient matching,ensuring a good outcome from xenotransplantation.Herein,we summarize the understanding of organ xenotransplantation in pigs-to-NHPs and highlight the current status and recent progress in extending the survival time of pig xenografts and recipients.We also discuss practical strategies for overcoming the obstacles to xenotransplantation mentioned above to further advance transplantation of pig organs in the clinic. | Xuan Zhang Quancheng Wang Jingjun Zhao Xiao Li Wei Peng Zhaoxu Yang Zhibin Lin Long Yang Rui Ding Kaishan Tao Kefeng Dou | 2021 | Science China(Life Sciences)2021，64，5： | 10 |
| 4 | Hard X-ray Imager (HXI) onboard the ASO-S mission显示文摘Hard X-ray Imager(HXI)is one of the three scientific instruments onboard the Advanced Spacebased Solar Observatory(ASO-S)mission,which is proposed for the 25th solar maximum by the Chinese solar community.HXI is designed to investigate the non-thermal high-energy electrons accelerated in solar flares by providing images of solar flaring regions in the energy range from 30 keV to 200 keV.The imaging principle of HXI is based on spatially modulated Fourier synthesis and utilizes about 91 sets of bi-grid sub-collimators and corresponding LaBr3 detectors to obtain Fourier components with a spatial resolution of about 3 arcsec and a time resolution better than 0.5 s.An engineering prototype has been developed and tested to verify the feasibility of design.In this paper,we present background,instrument design and the development and test status of the prototype. | Zhe Zhang Deng-Yi Chen Jian Wu Jin Chang Yi-Ming Hu Yang Su Yan Zhang Jian-Ping Wang Yao-Ming Liang Tao Ma Jian-Hua Guo Ming-Sheng Cai Yong-Qiang Zhang Yong-Yi Huang Xiao-Yan Peng Zong-Bin Tang Xuan Zhao Hong-He Zhou Lian-Guo Wang Jing-Xing Song Miao Ma Guang-Zhou Xu Jian-Feng Yang Di Lu Ying-Hong He Jin-You Tao Xiao-Long Ma Bao-Gang Lv Yan-Ping Bai Cai-Xia Cao Yu Huang Wei-Qun Gan | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 9 |
| 5 | Effects of Carboxymethyl-Chitosan on Wound Healing in vivo and in vitro显示文摘Effects of carboxymethyl-chitosan with different molecular weights on wound healing were investigated in vivo and in vitro.A second degree burn model was performed in rats and the accelerative effects of carboxymethyl-chitosan on wound repair were observed.Contents of transforming growth factor(TGF)-β1,interleukin(IL)-6 and matrix metalloproteinase(MMP)-1 in wounds were determined by enzyme-linked immunosorbent assay(ELISA).In vitro study evaluated the influence of carboxy-methyl-chitosan on cytokines secretion of fibroblasts and macrophages.In vivo results showed that carboxymethyl-chitosan effec-tively accelerated the wound healing process in burned rats(P<0.05).Levels of TGF-β1,IL-6 and MMP-1 in carboxymethyl-chitosan groups were significantly elevated,compared with control group(P<0.05).In vitro results indicated that carboxymethyl-chitosan significantly promoted the proliferation of fibroblasts and stimulated its IL-8 and IL-10 secretion at different incubation time,but it did not affect collagen secretion of fibroblasts.Carboxymethyl-chitosan enhanced phagocytosis ability of macrophages,and in-creased its tumor necrosis factor(TNF)-α secretion.In conclusion,carboxymethyl-chitosan promoted wound healing by activating macrophages,accelerating fibroblasts growth and exerting considerable effects on the secretion of a series of cytokines. | PENG Sikai LIU Wanshun HAN Baoqin CHANG Jing LI Minyu ZHI Xuan | 2011 | Journal of Ocean University of China2011，10，4： | 7 |
| 6 | Surface enhanced Raman spectroscopy signals of mixed pesticides and their identification显示文摘A rapid and sensitive method to identify and analyze mixed pesticides of tricyclazole,paraquat and flusilazole by surface-enhanced Raman scattering has been reported.Aqueous samples can be detected by SERS in low concentrations of 0.01 mg/L, 0.1 mg/L and 2.85 mg/L for individual tricyclazole,paraquat and flusilazole respectively.When mixing the three pesticides in the low concentrations,their characteristic peaks can still be identified from the SERS spectrum of the mixture. | Hui Rong Tang Qing Qing Li Yu Lan Ren Jin Pei Geng Peng Cao Tao Sui Xuan Wang Yi Ping Du | 2011 | Chinese Chemical Letters2011，22，12： | 7 |
| 7 | Carbon Monoxide Promotes Lateral Root Formation in Rapeseed显示文摘一氧化碳(公司) ,无臬、无味、无色的气体,最近证明了在哺乳动物的房间是活跃的一份重要简历或信号分子,主要由氮的氧化物与它的效果调停了(没有) 。在现在的报告,我们证明外长的公司导致侧根(LR ) 形成,一个没有依赖的过程。到油菜籽的 CO 施主血色素的管理(Brassicanapus L。Yangyou 6 ) 为 3 天的幼苗, dose-dependently 支持了全部的长度和 numberofLRs。这些回答也被看见跟随不同浸透的集中的气体的公司水溶液的应用程序。而且,幼苗上的公司的行动充分被颠倒 CO scavenger 血红素(Hb ) 或公司特定的合成禁止者锌 protoporphyrin-IX (ZnPPIX ) 什么时候被增加。有趣地,它的特定的scavenger2-( 4-carboxyphenyl ) -4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 钾腌的内长的 NO using ( cPTIO )的弄空或氮的氧化物 synthase ( NOS )禁止者 N^G-nitro-L-arginine 甲基酉旨(L名字),导致了完全的废除 ofLR 发展,说明一个重要角色为内长不在 LR 上的公司的行动形成。然而,由 200 亩 mol/L 钠 nitroprusside (SNP ) 的 LR 开发的正式就职,一没有施主,没被 ZnPPIX 的存在或缺席影响。而且,使用一条解剖途径与与没有特定的 fluorophore4,5-diaminofluorescein diacetate 扫描共焦的显微镜学的激光结合了,我们观察到血色素和 SNP 与控制样品增加了 NOreleasecompared 并且 NO 信号主要在 LR primordia (LRP ) 被散布,特别在 36 h 处理以后。LRP 被发现在控制有类似的形态学,对待 SNP 、对待血色素的幼苗。同样, NO 的改进由在 36 h 的公司的信号是 cPTIO, L 名字, ZnPPIX 和 Hb 的增加熄灭的差别。相反,正式就职不由 SNP 引起了没被 ZnPPIX 的申请影响。因此,我们进一步推断公司导致 LR 形成可能调停了由没有 / 没有小径并且可以不 COsignaling 下游地行动,它也被显示了发生在动物。 | Ze-Yu Cao Wei Xuan Zhao-Yang Liu Xin-Na Li Nan Zhao Peng Xu Zhe Wang Rong-Zhan Guan Wen-Biao Shen | 2007 | Journal of Integrative Plant Biology2007，49，7： | 7 |
| 8 | Different quasispecies with great mutations hide in the same subgroup J field strain of avian leukosis virus显示文摘Blood samples were collected from a local strain of chickens associated with serious tumor cases in Shandong Province.The samples were inoculated into chicken embryo fibroblast and DF-1 cells for virus isolation and identification,respectively.The inoculated cells were screened for three common chicken tumor viruses.Nine strains of avian leukosis virus subgroup J(ALV-J) were identified,and were designated LY1201‐LY1209.The env gene from the LY1201 strain was amplified and cloned.All nine resultant env clones(clones 01-09) were sequenced,and the gp85 and gp37 amino acid regions were subjected to homology analysis.Clones 01 and 03 had 10 amino acid deletions in the gp85 region compared to the other seven clones,suggesting that at least two quasispecies with obvious mutations coexist in the same field strain.Among these nine clones,three had identical gp85 and gp37 sequences,and were recognized as the dominant LY1201 quasispecies.The amino acid sequence homology of gp37 and gp85 among the nine clones was 98.5%-100.0% and 96.6%-100.0% respectively,suggesting that the gp85 region of the env gene can better display the quasispecies diversity of ALV-J than gp37. | MAO YaQing LI WeiHua DONG Xuan LIU JinHua ZHAO Peng | 2013 | Science China(Life Sciences)2013，56，5： | 6 |
| 9 | Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress显示文摘Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis(RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema heterophyllum Blume(AHA) and explore the possible mechanisms in human non-small-cell lung cancer A549 cells. AHA with purity up to 95% was isolated and purified from Arisaema heterophyllum Blume using hydrophobic interaction chromatography. AHA dose-dependently inhibited the proliferation of A549 cells and induced G_1 phase cell cycle arrest. AHA induced apoptosis by up-regulating pro-apoptotic Bax, decreasing anti-apoptotic Bcl-2, and activating caspase-9 and caspase-3. In A549 cells treated with AHA, the PI3K/Akt pathway was inhibited. Furthermore, AHA induced increase in the levels of ER stress markers such as phosphorylated eukaryotic initiation factor 2α(p-eIF2α), C/EBP-homologous protein(CHOP), inositol-requiring enzyme 1α(IRE1α), and phosphorylated c-Jun NH_2-terminal kinase(p-JNK). AHA also induced autophagy in A549 cells. Staining of acidic vesicular organelles(AVOs) and increase in the levels of LC3II and ATG7 were observed in AHA-treated cells. These findings suggested that AHA might be one of the active components with anti-cancer effects in Arisaema heterophyllum Blume. In conclusion, cytotoxicity of AHA on cancer cells might be related to its effects on apoptosis and autophagy through inhibition of PI3K/Akt pathway and induction of ER stress. | FENG Li-Xing SUN Peng MI Tian LIU Miao LIU Wang YAO Si CAO Yi-Min YU Xiao-Lu WU Wan-Ying JIANG Bao-Hong YANG Min GUO De-An LIU Xuan | 2016 | Chinese Journal of Natural Medicines2016，14，11： | 6 |
| 10 | Literature review of peripheral vascular trauma:Is the era of intervention coming?显示文摘Traumatic peripheral vascular injury is a significant cause of disability and death either in civilian environments or on the battlefield.Penetrating trauma and blunt trauma are the most common forms of vascular injuries.Besides,iatrogenic arterial injury(IAI)is another pattern of vascular trauma.The management of peripheral vascular injuries has been improved in different environments and wars.There are different types of vascular injuries,such as vasospasm,contusion,intimal flaps,intimal disruption or hematoma,external compression,laceration,transection and focal wall defects,etc.The main clinical manifestations of vascular injuries are shock following massive hemorrhage and limb necrosis due to tissue and organ ischemia.Ultrasound,computed tomography angiography(CTA)and magnetic resonance angiography(MRA)are most valuable for assessment of peripheral vascular injuries.Angiography remains the gold standard for diagnosing vascular trauma.Immediate hemorrhage control and rapid restoration of blood flow are the primary goals of vascular trauma treatment.There are many operative treatment methods for vascular injuries,such as vascular suture or ligation,vascular wall repair and vascular reconstruction with blood vessel prostheses or vascular grafts.Embolization,balloon dilation and covered stent implantation are the main endovascular techniques.Surgical operation is still the primary treatment for vascular injuries.Endovascular treatment is a promising alternative,proved to be safe and effective,and preferred selection for patients.In summary,rapid diagnosis and timely surgical intervention remain the mainstays of the treatment.However,many issues need to be resolved by further studies. | Jian-Long Liu Jin-Yong Li Peng Jiang Wei Jia Xuan Tian Zhi-Yuan Cheng Yun-Xin Zhang | 2020 | Chinese Journal of Traumatology2020，23，1： | 6 |
| 11 | COR27 and COR28 encode nighttime repressors integrating Arabidopsis circadian clock and cold response显示文摘It was noted that circadian components function in plant adaptation to diurnal temperature cycles and freezing tolerance.Our genome-wide transcriptome analysis revealed that evening-phased COR27 and COR28 mainly repress the transcription of clockassociated evening genes PRR5,ELF4 and cold-responsive genes.Chromatin immunoprecipitation indicated that CCA1 is recruited to the site containing EE elements of COR27 and COR28 promoters in a temperaturedependent way.Further genetic analysis shows COR28 is essential for the circadian function of PRR9 and PRR7.Together,our results support a role of COR27 and COR28 as nighttime repressors integrating circadian clock and plant cold stress responses. | peng wang xuan cui chunsheng zhao liyan shi guowei zhang fenglong sun xiaofeng cao li yuan qiguang xie xiaodong xu | 2017 | Journal of Integrative Plant Biology2017，59，2： | 6 |
| 12 | Reveal training performance mystery between Tensor Flow and PyTorch in the single GPU environment显示文摘Deep learning has gained tremendous success in various fields while training deep neural networks(DNNs)is very compute-intensive,which results in numerous deep learning frameworks that aim to offer better usability and higher performance to deep learning practitioners.Tensor Flow and Py Torch are the two most popular frameworks.Tensor Flow is more promising within the industry context,while Py Torch is more appealing in academia.However,these two frameworks differ much owing to the opposite design philosophy:static vs dynamic computation graph.Tensor Flow is regarded as being more performance-friendly as it has more opportunities to perform optimizations with the full view of the computation graph.However,there are also claims that Py Torch is faster than Tensor Flow sometimes,which confuses the end-users on the choice between them.In this paper,we carry out the analytical and experimental analysis to unravel the mystery of comparison in training speed on single-GPU between Tensor Flow and Py Torch.To ensure that our investigation is as comprehensive as possible,we carefully select seven popular neural networks,which cover computer vision,speech recognition,and natural language processing(NLP).The contributions of this work are two-fold.First,we conduct the detailed benchmarking experiments on Tensor Flow and Py Torch and analyze the reasons for their performance difference.This work provides the guidance for the end-users to choose between these two frameworks.Second,we identify some key factors that affect the performance,which can direct the end-users to write their models more efficiently. | Hulin DAI Xuan PENG Xuanhua SHI Ligang HE Qian XIONG Hai JIN | 2022 | Science China(Information Sciences)2022，65，1： | 6 |
| 13 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 14 | Large-area high quality PtSe2 thin film with versatile polarity显示文摘Two-dimensional(2D)materials have attracted increasing attention for their outstanding structural and electrical properties.However,for mass-production of field effect transistors(FETs)and potential applications in integrated circuits,large-area and uniform 2D thin films with high mobility,large on-off ratio,and desired polarity are needed to synthesize firstly.Here,a transfer-free growth method for platinum diselenide(PtSe2)films has been developed.The PtSe2 films have been synthesized with various thicknesses in centimeter-sized scale.Typical FET made from a few layer PtSe2 show p-type unipolar,with a high field-effect hole mobility of 6.2 cm^(2) V^(−1) s^(−1) and an on-off ratio of 5×10^(3).The versatile semimetal-unipolar-ambipolar transition in synthesized PtSe2 films is also firstly observed as the thickness thinning.This work realizes the large-scale preparation of PtSe2 with prominent electrical properties and provides a new strategy for polarity's modulation. | Wei Jiang Xudong Wang Yan Chen Guangjian Wu Kun Ba Ningning Xuan Yangye Sun Peng Gong Jingxian Bao Hong Shen Tie Lin Xiangjian Meng Jianlu Wang Zhengzong Sun | 2019 | InfoMat2019，1，2： | 5 |
| 15 | Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells显示文摘Our previous studies found that mitochondrial uncouplers CCCP and niclosamide inhibited artery constriction and the mechanism involved AMPK activation in vascular smooth muscle cells. BAM15 is a novel type of mitochondrial uncoupler. The aim of the present study is to identify the vasoactivity of BAM15 and characterize the BAM15-induced AMPK activation in vascular smooth muscle cells(A10 cells). BAM15 relaxed phenylephrine(PE)-induced constricted rat mesenteric arteries with intact and denuded endothelium. Pretreatment with BAM15 inhibited PEinduced constriction of rat mesenteric arteries with intact and denuded endothelium. BAM15, CCCP,and niclosamide had the comparable IC50 value of vasorelaxation in PE-induced constriction of rat mesenteric arteries. BAM15 was less cytotoxic in A10 cells compared with CCCP and niclosamide.BAM15 depolarized mitochondrial membrane potential, induced mitochondrial fission, increased mitochondrial ROS production, and increased mitochondrial oxygen consumption rate in A10 cells.BAM15 potently activated AMPK in A10 cells and the efficacy of BAM15 was stronger than that of CCCP, niclosamide, and AMPK positive activators metformin and AICAR. In conclusion, BAM15 activates AMPK in vascular smooth muscle cells with higher potency than that of CCCP, niclosamide and the known AMPK activators metformin and AICAR. The present work indicates that BAM15 is a potent AMPK activator. | Yu Tai Lanjun Li Xuan Peng Junxue Zhu Xihai Mao Nan Qin Minghui Ma Rong Huo Yunlong Bai Deli Dong | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 5 |
| 16 | Prevalence and Determinants of High-risk HPV Infection among 11549 Women from an Opportunistic Screening in Hubei Province显示文摘High-risk human papillomavirus (hrHPV) infection plays an important role in the development of cervical intraepithelial neoplasia and cervical cancer.A total of 11 549 women were enrolled from the Maternal and Child Health Hospital of Hubei Province.Each participant accepted hrHPV testing and completed a self^administered questionnaire about basic information and potential risk factors.The univariable and multivariable logistic regression model was used to explore the associations between variants and hrHPV infection.Our results showed that hrHPV prevalence was 16.09% in Hubei Province,among which,hrHPV was more likely to be positive in women aged 51 years or above (OR=1.65,95% CI:1.28-2.14),and in women who had symptoms of bleeding after intercourse (OR=1.32,95% CI:1.17-1.50),had first sexual intercourse at the age of 18 years or below (OR=1.33,95% CI:1.07-1.64),had at least three male sexual partners (OR=2.50,95% CI:2.07-3.03),and who had been diagnosed with sexually transmitted infections (OR=1.50,95% CI:1.12-2.03).Married women (OR=0.66,95% CI:0.55-0.78) and women who frequently used condoms (OR=0.75,95% CI:0.67-0.84) had a relatively lower hrHPV prevalence.This study confirms that hrHPV infection was associated with age,marital status,symptoms of intercourse bleeding,history of sexually transmitted infections,and sex-related behaviors.Above all,this study provides a baseline database prior to obtaining vaccinations for dynamic tracking of the changes in hrHPV prevalence. | Quan-fu MA Yu-lin GUO Han GAO Bin YAN Xuan DAI Meng XU Yu-jing XIONG Qiu-zi PENG Ying WANG Miao ZOU Xu-feng WU | 2019 | Current Medical Science2019，39，4： | 5 |
| 17 | Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury显示文摘Spinal cord injury(SCI)is a serious traumatic disease of the central nervous system,which can give rise to the loss of motor and sensory function.Due to its complex pathological mechanism,the treatment of this disease still faces a huge challenge.Hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord.Hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that hydrogel-based therapy can effectively eliminate inflammation and promote spinal cord repair and regeneration to improve SCI.In this review,hydrogel-based multimodal therapeutic strategies to repair SCI are provided,and a combination of hydrogel scaffolds and other therapeutic modalities are discussed,with particular emphasis on the repair mechanism of SCI. | Yan Wang Hong-Qian Lv Xuan Chao Wen-Xin Xu Yun Liu Gui-Xia Ling Peng Zhang | 2022 | Military Medical Research2022，9，5： | 5 |
| 18 | Porous surfur-doped hard carbon for excellent potassium storage显示文摘Hard carbon is promising anode for potassium-ion batteries(PIBs),however,the poor rate capability hinders its development as potential anode.To address this question,we design a sulfur-doped porous hard carbon(S-HC)for PIBs through the combination of structural design and composition adjustment.The as-designed S-HC exhibits a long cycling life with^191 mAh/g after 300 cycles at 1 A/g,and an excellent rate capability with^100 mAh/g at 5 A/g,which was attributed to its structural characteristics and compositions.The S-HC demonstrates to be promising anode in the future. | Xuan Xie Shihan Qi Daxiong Wu Huaping Wang Fang Li Xiaoxin Peng Jinfeng Cai Jiaojiao Liang Jianmin Ma | 2020 | Chinese Chemical Letters2020，31，1： | 4 |
| 19 | Bufalin derivative BF211 inhibits proteasome activity in human lung cancer cells in vitro by inhibiting β1 subunit expression and disrupting proteasome assembly显示文摘 | Peng SUN Li-xing FENG Dong-mei ZHANG Miao LIU Wang LIU Tian MI Wan-ying WU Bao-hong JIANG Min YANG Li-hong HU De-an GUO Xuan LIU | 2016 | Acta Pharmacologica Sinica2016，37，7： | 4 |
| 20 | A New Method for Blood NT-proBNP Determination Based on a Near-infrared Point of Care Testing Device with High Sensitivity and Wide Scope显示文摘Objective To develop a rapid, highly sensitive, and quantitative method for the detection of NT-proBNP levels based on a near-infrared point-of-care diagnostic(POCT) device with wide scope. Methods The lateral flow assay(LFA) strip of NT-proBNP was first prepared to achieve rapid detection. Then, the antibody pairs for NT-proBNP were screened and labeled with the near-infrared fluorescent dye Dylight-800. The capture antibody was fixed on a nitrocellulose membrane by a scribing device. Serial dilutions of serum samples were prepared using NT-proBNP-free serum series. The prepared test strips, combined with a near-infrared POCT device, were validated by known concentrations of clinical samples. The POCT device gave the output of the ratio of the intensity of the fluorescence signal of the detection line to that of the quality control line. The relationship between the ratio value and the concentration of the specimen was plotted as a work curve. The results of 62 clinical specimens obtained from our method were compared in parallel with those obtained from the Roche E411 kit. Results Based on the log-log plot, the new method demonstrated that there was a good linear relationship between the ratio value and NT-proBNP concentrations ranging from 20 pg/mL to 10 ng/mL. The results of the 62 clinical specimens measured by our method showed a good linear correlation with those measured by the Roche E411 kit. Conclusion The new LFA detection method of NT-proBNP levels based on the near-infrared POCT device was rapid and highly sensitive with wide scope and was thus suitable for rapid and early clinical diagnosis of cardiac impairment. | ZHANG Xiao Guang SHU Yao Gen GAO Ju WANG Xuan LIU Li Peng WANG Meng CAO Yu Xi ZENG Yi | 2017 | Biomedical and Environmental Sciences2017，30，6： | 4 |
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