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| 1 | Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing显示文摘Gastric cancer(GC) is a highly heterogeneous disease with multiple cellular types and poor prognosis.However, the cellular evolution and molecular basis of GC at the individual intra-tumor level has not been well demonstrated. We performed single-cell whole exome sequencing to detect somatic singlenucleotide variants(SNVs) and significantly mutated genes(SMGs) among 34 tumor cells and 9 normal cells from a patient with GC. The Complete Prediction for Protein Conformation(CPPC) approach directly predicting the folding conformation of the protein 3D structure with Protein Folding Shape Code, combined with functional experiments were used to confirm the characterization of mutated SMGs in GC cells. We identified 201 somatic SNVs, including 117 non-synonymous mutations in GC cells. Further analysis identified 24 significant mutated genes(SMGs) in single cells, for which a single amino acid change might affect protein conformation. Among them, two genes(CDC27 and FLG) that were mutated only in single cells but not in the corresponding tumor tissue, were recurrently present in another GC tissue cohort, and may play a potential role to promote carcinogenesis, as confirmed by functional characterization. Our findings showed a mutational landscape of GC at intra-tumor level for the first time and provided opportunities for understanding the heterogeneity and individualized target therapy for this disease. | Lihua Peng Rui Xing Dongbing Liu Li Bao Wenxiang Cheng Hongyi Wang Yuan Yu Xiaofeng Liu Lu Jiang Yan Wu Zhongxue An Qiaoyi Liang Ryong Nam Kim Young Kee Shin Huanming Yang Jian Wang Jun Yu Xiuqing Zhang Xun Xu Jiaan Yang Kui Wu Shida Zhu Youyong Lu | 2019 | Science Bulletin2019，64，4： | 3 |
| 2 | Bimodal PE prepared with combined iron (II) and nickel (II) olefin polymerization catalysts显示文摘Combined iron (II) and nickel (II) olefin polymerization catalysts could produce a kind of PE having the characters of ideal bimodal PE with ap- propriate conditions and catalysts. In the ethylene homopolymerization with triethylalkylaluminum (AlEt3) as the activator, the prepared bimodal PE contained not only branched PE of high molecular weight, but also linear PE of low molecular weight. And the amounts of both fractions were similar. Ideal bimodal PE resin was prepared in one polymerization reactor. | WANG Shibo LIU Dongbing XU Renwei MAO Bingquan | 2006 | Chinese Science Bulletin2006，51，1： | 1 |
| 3 | The influence of silicone finishes on thermooxidative stabilization of PAN precursor fibers显示文摘 | Jin Dongbing Huang Ying Liu Xiangluan | 2004 | J Mater Sci2004，39，10： | 1 |
| 4 | Continental and oceanic crustrecycling-induced melt-peridotite interactions in theTrans-North China Orogen: U-Pb dating, Hf isotopes andtrace elements in zircons of mantle xenoliths 显示文摘 | Liu Yongsheng Gao Shan Hu Zhaochu Gao Changgui ZongKeqing Wang Dongbing | 2010 | J Petrol2010，51，53： | 1 |
| 5 | The in- fluences of silicone finishes on thermooxidative stabilization of PAN precursor fibers显示文摘 | Jin Dongbing Huang Ying Liu Xiangluan | 2004 | J Mater Sei2004，39，10： | 1 |
| 6 | Preparation of spherical MgC12 - supported bis ( phenoxy - imine ) zirconium complex for ethylene polymerization 显示文摘 | Xu Renwei Liu Dongbing Wang Shibo | 2007 | J Mol Catal A : Chem2007，213，： | 1 |
| 7 | Spherical MgCl2 supported iron catalyst for ethylene polymerization: effect of the preparation procedure on catalyst activity and the morphology of polyethylene particles 显示文摘 | Huang Rubin Liu Dongbing Mao Bingquan | 2004 | Macromol Chem Phys2004，205，7： | 1 |
| 8 | A No- vel Orange Juice Concentration Method Based on C2H4 Clathrate Hydrate Formation 显示文摘 | Shifeng Li Yanming Shen Dongbing Liu | 2014 | Advance Journal of Food Science and Technology2014，6，6： | 1 |
| 9 | cAMP-PGC1α途径诱导的抗Warburg效应驱动胶质母细胞瘤细胞分化为星形胶质细胞显示文摘文章简介多形性胶质母细胞瘤(GBM)是人类最具侵袭性的肿瘤之一。虽然分化治疗已被提出作为治疗GBM的潜在方法,但诱导分化的机制仍然很不清楚。在此,课题组利用c AMP激活剂建立了GBM诱导分化模型,该模型特异性地指导GBM分化为星形胶质细胞。 | Fan Xing Yizhao Luan Jing Cai Sihan Wu Jialuo Mai Jiayu Gu Haipeng Zhang Kai Li Yuan Lin Xiao Xiao Jiankai Liang Yuan Li Wenli Chen Yaqian Tan Longxiang Sheng Bingzheng Lu Wanjun Lu Mingshi Gao Pengxin Qiu Xingwen Su Wei Yin Jun Hu Zhongping Chen Ke Sai Jing Wang Furong Chen Yinsheng Chen Shida Zhu Dongbing Liu Shiyuan Cheng 谢志 朱文博 颜光美 | 2018 | 科学新闻2018，0，4： | 1 |
| 10 | Heavy Ion Induced Fragmentation of Adenine Biomolecule显示文摘 | Ma Xinwen Li Bin Li Chen Richard Bredy Zhu Xiaolong Liu Huiping Zhang Shaofeng Feng Wentian Qian Dongbing Cao Shiping Zhang Dacheng | 2006 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2006，，1： | 0 |
| 11 | Multiple Electron Capture Processes in Slow Collisions of Ar^(9+) Ions with Na Atoms显示文摘Slow collisions of highly charged ions with neutral atoms and molecules are of great importance in basic atomic collision physics, Recently, we built a new research facility for atomic physics at the Institute of Modern Physics. We report here the multiple electron transfer processes in collisions of Ar^9+ with Na gas target at energy of 180 keV. | Zhu Xiaolong, Sha Shan, Liu Huiping, Wei Baoren, Ma Xinwen, Wang Zhengling Cao Shiping, Qian Dongbing and Yang Zhihu | 2003 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2003，，1： | 0 |
| 12 | 4 - 11 Cusp Electron Emission in Transfer Ionization of Intermediate-energy He2+ Collision with Argon显示文摘 | Zhang Ruitian Ma Xinwen Zhang Shaofeng Zhu Xiaolong FengWentian Guo Dalong Li Bing Qian Dongbing Liu Huiping Yan Shuncheng Zhang Pengju | 2012 | IMP & HIRFL Annual Report2012，，1： | 0 |
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