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		题名	作者	年代	出处	被引量
	1	Cryo-copolymerization preparation of dextran-hyaluronate based supermacroporous cryogel scaffolds for tissue engineering applications显示文摘Dextran-hyaluronate (Dex -- 哈) 为软织物工程的基于的 supermacroporous cryogel 脚手架被在结冰条件下面在各种各样的 macromonomer 集中包含葡聚糖 methacrylate (Dex 麻省) 和 hyaluronate methacrylate (哈麻省) 的水的答案的免费激进的 cryo-copolymerization 准备。这被观察为 Dex 的准备的 macromonomers 的合适的全部的集中 -- 哈有满足的性质的 cryogel 支架是 5%(w/w ) 在 1% 的哈麻省集中(w/v ) ,它然后被用来生产测试支架。有 5% 的获得的 cryogel 支架(w/w ) macromonomer 答案有高水位线渗透(5.1 ? 桴 ? 潨灳瑩?	Dongjiao ZHOU Shaochuan SHEN Junxian YUN Kejian YAO Dong-Qiang LIN	2012	Frontiers of Chemical Science and Engineering2012，6，3：	1
	2	Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway显示文摘Emerging evidence suggested that zinc finger protein 831(ZNF831)was associated with immune activity and stem cell regulation in breast cancer.Whereas,the roles and molec-ular mechanisms of ZNF831 in oncogenesis remain unclear.ZNF831 expression was significantly diminished in breast cancer which was associated with promoter CpG methylation but not mu-tation.Ectopic over-expression of ZNF831 suppressed breast cancer cell proliferation and col-ony formation and promoted apoptosis in vitro,while knockdown of ZNF831 resulted in an opposite phenotype.Anti-proliferation effect of ZNF831 was verified in vivo.Bioinformatic analysis of public databases and transcriptome sequencing both showed that ZNF831 could enhance apoptosis through transcriptional regulation of the JAK/STAT pathway.ChiP and luciferase report assays demonstrated that ZNF831 could directly bind to one specific region of STAT3 promoter and induce the transcriptional inhibition of STAT3.As a result,the attenuation of STAT3 led to a restraint of the transcription of Bcl2 and thus accelerated the apoptotic progression.Augmentation of STAT3 diminished the apoptosis-promoting effect of ZNF831 in breast cancer cell lines.Furthermore,ZNF831 could ameliorate the anti-proliferation effect of capecitabine and gemcitabine in breast cancer cell lines.Our findings demonstrate for the first time that ZNF831 is a novel transcriptional suppressor through inhibiting the expression of STAT3/Bcl2 and promoting the apoptosis process in breast cancer,suggesting ZNF831 as a novel biomarker and potential therapeutic target for breast cancer patients.	Jun Fan Zhe Zhang Hongqiang Chen Dongjiao Chen Wenbo Yuan Jingzhi Li Yong Zeng Shimeng Zhou Shu Zhang Gang Zhang Jiashen Xiong Lu Zhou Jing Xu Wenbin Liu Yan Xu	2024	Genes & Diseases2024，11，1：	0

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