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| 1 | Stimulus-responsive polymeric nanoparticles for biomedical applications显示文摘Polymeric nanoparticles with unique properties are regarded as the most promising materials for biomedical applications including drug delivery and in vitro/in vivo imaging.Among them,stimulus-responsive polymeric nanoparticles,usually termed as 'intelligent' nanoparticles,could undergo structure,shape,and property changes after being exposed to external signals including pH,temperature,magnetic field,and light,which could be used to modulate the macroscopical behavior of the nanoparticles.This paper reviews the recent progress in stimulus-responsive nanoparticles used for drug delivery and in vitro/in vivo imaging,with an emphasis on double/multiple stimulus-responsive systems and their biomedical applications. | LI YongYong1,2,DONG HaiQing1,2,WANG Kang1,SHI DongLu 2,ZHANG XianZheng1 & ZHUO RenXi1 1Key Laboratory of Biomedical Polymers,Ministry of Education Department of Chemistry,Wuhan University,Wuhan 430072,China 2Institute for Advanced Materials and Nano Biomedicine(iNANO),Tongji University,Shanghai 200092,China | 2010 | Science China Chemistry2010，53，3： | 11 |
| 2 | A critical review on the health promoting effects of mushrooms nutraceuticals显示文摘Extensive elucidations focusing on the efficient health promoting properties and high nutritional values of mushrooms have been expanded dynamically from the past few decades.Due to its high quality of proteins,polysaccharides,unsaturated fatty acids,mineral substances,triterpenes sterols and secondary metabolites,mushrooms have always been appreciated for their vital role in protecting and curing various health problems,such as immunodeficiency,cancer,inflammation,hypertension,hyperlipidemia,hypercholesterolemia and obesity.Moreover,investigations in recent years have revealed the correlations between the health-promoting benefits and gut microbiota regulating effects induced by the mushrooms intake.Researches on the immense role in the nutritional and health benefits displayed by mushrooms have become an emergent task to study.The present article overviewed and compiled the latest information correlated to the health benefits and underlying functional mechanisms of mushroom nutraceuticals,and concluded that the supplementation of mushrooms as a dietary composition could become a natural adjuvant for the prevention and treatment of several health diseases. | Gaoxing Ma Wenjian Yang Liyan Zhao Fei Pei Donglu Fang Qiuhui Hu | 2018 | Food Science and Human Wellness2018，7，2： | 10 |
| 3 | Interaction of rice bZIP protein REB with the 5'-upstream region of both rice sbe1 gene and waxy gene显示文摘Rice starch branching enzyme 1 (SBE1) and granule-bound starch synthase (GBSS) catalyzed the bio-synthesis of amylopectin and amylose in rice developing en-dosperm respectively, and the genes encoding these two en-zymes, sbe1 and waxy, are mainly expressed in the en-dosperm. Within the 5 ’-upstream region of rice sbel gene, we identified a 53 bp fragment C53 which could interact with the nuclear proteins extracted from rice endosperm. We also found that fragment Ha-2 in the 5 ’-upstream region of rice waxy gene could compete with C53 for its interaction. Fur-ther experiments demonstrated that rice bZIP protein REB could interact with two ACGT elements (G-box and Hex) in the fragment C53 as well as three ACGT elements (WG1, WG2, and WG3) in the fragment Ha-2. The WG1 element could compete well with Hex element for its interaction with REB. These results suggested that the expression of sbel and waxy gene in rice developing endosperm may be coordinately regulated by REB-like bZIP transcriptional factors. | CAI Yi, XIE Donglu, WANG Zongyang & HONG MengminState Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032, China | 2002 | Chinese Science Bulletin2002，47，4： | 5 |
| 4 | In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy显示文摘Graphene 氧化物 / 黄金 nanorod (GO/GNR ) nanohybrids 被混合聚苯乙烯 sulfonate (PSS ) 在房间温度在 situ 生长方法与 GO-seed-mediated 和 gold-seed-mediated 综合 functionalized 去,第二等的生长答案,和金种子。与 GO/GNRs 或 graphene (G)/GNRs 的前 situ 准备方法相比,在里面 GO/GNRs 的 situ 合成在他们的附件前处理了 GNR 的聚集的问题到 GO 上。方法直接、环境友好。GO/GNRs 在 vitro 显示出显著 photothermal 效果。GO/GNR nanohybrids 的温度在女人上从 25 ~ 49.9 增加了光谱为宽事件角度的范围(365 ~ 1,100 nm )(0io 是超过 6.00 ~ 10 个病人和 35 age-/gender-matched 控制(吝啬的 s 吗?? | Bingmei Sun Jinrui Wu Shaobin Cui Huanhuan Zhu Wei An Qingge Fu Chengwei Shao Aihua Yao Bingdi Chen Donglu Shi | 2017 | Nano Research2017，10，1： | 4 |
| 5 | Electroless Plating of Thin Silver Films on Porous Al_2O_3 Substrate and the Study of Deposition Kinetics显示文摘A novel concept has been developed to coat the inner pore surfaces of reticulated alumina with a thin silver film by an electroless-plating method. As a result of coating, the porous alumina sample exhibits a sharp transition from insulating to conducting due to a thin silver layer on the inner pore surfaces. System- atic studies have been carried out to investigate the coating kinetics by employment of scanning electron microscope (SEM), X-ray diffraction (XRD), and computer simulation. Both coating procedures and effects of processing parameters on the quality of films are reported. Also, this paper presents the film bonding strength to the substrate, effects of sintering, and conduction mechanism of coated composite. The funda- mental silver electroless-plating mechanism has been identified based on computer modeling. The simula- tion results indicate an excellent agreement between the silver deposition behavior and the physical model applied. | Fang Mei Donglu Shi | 2005 | Tsinghua Science and Technology2005，10，6： | 4 |
| 6 | Potential coordination role between O-GIcNAcylation and epigenetics显示文摘translational 以后 O-GlcNAc 修正(O-GlcNAcylation ) 的动态变化被连接 O 的 -N-acetylglucosamine (O-GlcNAc ) 控制 transferase (OGT ) 和在房间的 glycoside hydrolase O-GlcNAcase (OGA ) 。O-GlcNAcylation 经常由 OGT 经由 O-GlcNAc 组的增加发生在丝氨酸(重量的单位) 和特定的底层蛋白质的 threonine (Thr ) 残余上。O-GlcNAcylation 是,这被知道了不仅通过各种各样的机制在癌症开发在许多基本细胞的过程,而且戏包含了一个重要角色。最近,积累数据在 histones 揭示那 O-GlcNAcylation 或 non-histone 蛋白质能导致随后的生物进程的开始,作为蛋白质代码或 histone 代码建议那 O-GlcNAcylation 可以提供识别平台或行政指令让蛋白质的随后的招募执行特定的函数。在这评论,我们总结 O-GlcNAcylation 和 epigenetic 变化的相互作用,介绍在 O-GlcNAcylation 和 epigenetic 之间的连接串音改变的最近的研究调查结果,并且在有在细胞内部的生物过程的 epigenetic 变化的 O-GlcNAcylation 的潜在的协作角色上推测。 | Donglu Wu Yong Cai Jingji Jin | 2017 | Protein & Cell2017，8，10： | 3 |
| 7 | Preclinical experimental models of drug metabolism and disposition in drug discovery and development显示文摘Drug discovery and development involve the utilization of in vitro and in vivo ex perimental models.Different models,ranging from test tube experiments to cell cultures,animals,healthy human subjects,and even small numbers of patients that are involved in clinical trials,are used at different stages of drug discovery and development for determination of efficacy and safety.The proper selection and applications of correct models,as well as appropriate data interpretation,are critically important in decision making and succesful advancement of drug candidates.In this review,we discuss strategies in the applications of both in vitro and in vivo.experimental models of drug metabolism and disposition. | Donglu Zhang Gang Luo Xinxin Ding Chuang Lu | 2012 | Acta Pharmaceutica Sinica B2012，2，6： | 2 |
| 8 | Plasma deposition and characterization of acylic acid thin film on ZnO nanoparticles显示文摘 | Shi Donglu Peng He | 2002 | Material Research2002，17，10： | 1 |
| 9 | Surface Resistance of Single Domain YBCO 显示文摘 | Qu D Donglu H A Blackstead Altan Ferendeci | 2000 | Physica C2000，，26： | 1 |
| 10 | Plasma deposition and characterization of acylic acid thin film on ZnO nanoparticles显示文摘 | He Peng | 2002 | Material Research2002，17，10： | 1 |
| 11 | Synthetic of hydroxyapatite films on porous Al2O3 substrate for hard tissue prosthetics显示文摘 | Shi Donglu Jiang Guowei | 1998 | Materials Science and Engineering C1998，6，23： | 1 |
| 12 | Metabolism,pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits显示文摘 | Donglu Z Kan H Nirmala R | 2010 | J Thromb Thrombolysis2010，29，1： | 1 |
| 13 | Plasma deposition and characterization of acrylic acid thin film on ZnO nanoparticles显示文摘 | DONGLU S PENG H | 2002 | Materials Research2002，17，10： | 1 |
| 14 | 显示文摘 | | 2002 | Applied Physics Letters2002，5，： | 1 |
| 15 | Plasma deposition and characterization of acrylic acid thin film on ZnO nanoparticles显示文摘 | SHI Donglu HE Peng | 2002 | Materials Research2002，17，10： | 1 |
| 16 | Plasma deposition of uhrathin polymer films on carbon nanotubes显示文摘 | Shi Donglu Lian Jie He Peng | 2002 | Applied Physics Letters2002，81，27： | 1 |
| 17 | Surface modification of nanoparticles and nanotubes by plasma polymerization 显示文摘 | Shi Donglu He Peng | 2004 | Advanced Material Science2004，，7： | 1 |
| 18 | Enhanced thermal stability of carbon nanotubes by plasma surface modification in AI203 composites 显示文摘 | Hoonsung Cho Donglu Shi Yan Guo | 2008 | Applied Physics Letters2008，104，： | 1 |
| 19 | In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes 显示文摘 | Yan Guo Donglu Shi Hoonsung Cho | 2008 | Advanced Functional Materials2008，18，： | 1 |
| 20 | Plasma deposition and charac- terization of acrylic acid thin film on ZnO nanoparticles 显示文摘 | Shi Donglu He Peng Lian Jie | 2002 | Journal of Materials Research2002，17，： | 1 |
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