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您的检索式：作者名="Dongwu YANG"
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| 1 | Molecular basis for ligand activation of the human KCNQ2 channel显示文摘The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy,pain and several other diseases related to neuronal hyper-excitability.A list of synthetic compounds have been developed to directly activate KCNQ2,yet our knowledge of their activation mechanism is limited,due to lack of high-resolution structures.Here,we report cryo-electron microscopy(cryo-EM)structures of the human KCNQ2 determined in apo state and in complex with two activators,ztz240 or retigabine,which activate KCNQ2 through different mechanisms.The activator-bound structures,along with electrophysiology analysis,reveal that ztz240 binds at the voltage-sensing domain and directly stabilizes it at the activated state,whereas retigabine binds at the pore domain and activates the channel by an allosteric modulation.By accurately defining ligand-binding sites,these KCNQ2 structures not only reveal different ligand recognition and activation mechanisms,but also provide a structural basis for drug optimization and design. | Xiaoxiao Li Qiansen Zhangc Peipei Guo Jie Fu Lianghe Mei Dashuai Lv Jiangqin Wang Dongwu Lai Sheng Ye Huaiyu Yang Jiangtao Guo | 2021 | Cell Research2021，31，1： | 3 |
| 2 | Influence and experiment of cable-net manufacturing errors on surface accuracy of mesh reflector antennas显示文摘Cable-net structures are of substantial importance in the construction of large mesh reflector antennas.Owing to the inevitable errors in their manufacturing process,the reflector surface accuracy deteriorates.This study makes a comprehensive investigation of random manufacturing errors during constructing the mesh reflector antennas,and analyze its influence on reflector surface accuracy.Firstly,the sensitivity of reflector surface accuracy with respect to the random errors of the unstressed cable length is mathematically deducted.Secondly,a non-button connecting method is proposed and analyzed to reduce manufacturing errors.Thirdly,two physical experiment models based on 2.62-meter mesh reflector antenna are made.Finally,numerical examples and experimental tests are given to demonstrate the effectiveness of the proposed method.Compared with the traditional method,the proposed method can effectively reduce the influence of the manufacturing errors on the reflector surface accuracy.Moreover,the reduction in the sizes of the nodes also reduces the risk of entanglement of the mesh reflector antenna during the deployment process,and thereby improves the deployment reliability. | Zihan SUN Baoyan DUAN Yiqun Zhang Dongwu YANG | 2023 | Chinese Journal of Aeronautics2023，36，2： | 0 |
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