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| 1 | 晚期非小细胞肺癌免疫检查点抑制剂新型生物标志物:血液PD-L1动态检测显示文摘背景免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)具有良好疗效已成为恶性肿瘤治疗领域备受瞩目的翘楚。然而,仅有小部分患者获得长期临床获益。如何选择生物标志物来筛查ICIs治疗优势人群仍是一大热点。方法收集51例晚期恶性肿瘤患者的肿瘤组织和配对血样本,进行PD-L1表达的相关性分析。40例晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者接受ICIs治疗,2个月时检测血液PD-L1(bloodPD-L1,bPD-L1)表达的动态变化,包括PD-L1 mRNA、外泌体PD-L1(exosomalPD-L1,exoPD-L1)蛋白和可溶性PD-L1(solublePD-L1,sPD-L1)。应用R软件计算最佳截断值,用于预测最佳客观缓解(best objective response,b OR)、无进展生存期(progression-free survival,PFS)和总生存期(overall survival,OS)。结果51例不同恶性肿瘤患者中,组织PD-L1(tissuePD-L1,tPD-L1)表达阳性患者的PD-L1mRNA表达水平显著升高。40例接受ICIs治疗的晚期NSCLC患者中,bPD-L1 mRNA上调≥2.04的患者b OR、PFS和OS更佳;21例接受ICIs治疗的晚期NSCLC患者中,exoPD-L1上调≥1.86的患者临床获益更大。sPD-L1动态变化与ICIs疗效无显著相关性。PD-L1 mRNA和exoPD-L1联合检测更有利于预测ICIs治疗疗效。结论bPD-L1表达与tPD-L1表达存在正相关;晚期NSCLC患者ICIs治疗初期PD-L1 mRNA和(或)exoPD-L1表达升高,可作为评估临床获益的新型生物标志物。 | Qiao YANG Mingjing CHEN Jiaoyang GU Kai NIU Xianlan ZHAO Linpeng ZHENG Zihan XU Yongxin YU Feng LI Lingxin MENG Zhengtang CHEN Wenlei ZHUO Luping ZHANG Jianguo SUN 杨峤(译) 孙建国(译) | 2021 | 中国肺癌杂志2021，24，12： | 10 |
| 2 | Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes显示文摘Background:To test clinically relevant factors associated with quantitative artifact-free deep capillary plexus(DCP)metrics in patients with diabetes mellitus(DM).Methods:563 eligible eyes(221 with no diabetic retinopathy[DR],135 with mild DR,130 with moderate DR,and 77 with severe DR)from 334 subjects underwent optical coherence tomography-angiography(OCT-A)with a swept-source OCT(Triton DRI-OCT,Topcon,Inc.,Tokyo,Japan).Strict criteria were applied to exclude from analysis those DCP images with artifacts and of poor quality,including projection artifacts,motion artifacts,blurriness,signal loss,B-scan segmentation error,or low-quality score.A customized MATLAB program was then used to quantify DCP morphology from the artifact-free DCP images by calculating three metrics:foveal avascular zone(FAZ),vessel density(VD),and fractal dimension(FD).Results:166(29.5%)eyes were excluded after quality control,leaving in the analysis 397 eyes(170 with no DR,101 with mild DR,90 with moderate DR,36 with severe DR)from 250 subjects.In the multiple regression models,larger FAZ area was associated with more severe DR(β=0.687;p=0.037),shorter axial length(AL)(β=−0.171;p=0.003),thinner subfoveal choroid thickness(β=−0.122;p=0.031),and lower body mass index(BMI)(β=−0.090;p=0.047).Lower VD was associated with more severe DR(β=−0.842;p=0.001),shorter AL(β=0.107;p=0.039),and poorer visual acuity(VA)(β=−0.133;p=0.021).Lower FD was associated with more severe DR(β=−0.891;p<0.001)and with older age(β=−0.142;p=0.004).Conclusions:Quantitative artifact-free DCP metrics are associated with VA,DR severity,AL,subfoveal choroidal thickness,age,and BMI in diabetic patients.The effects of ocular and systemic factors should be considered for meaningful interpretations of DCP changes in DM patients. | Fang Yao Tang Erica O.Chan Zihan Sun Raymond Wong Jerry Lok Simon Szeto Jason C.Chan Alexander Lam Clement C.Tham Danny S.Ng Carol Y.Cheung | 2020 | Eye and Vision2020，7，1： | 7 |
| 3 | Architectural proteins for the formation and maintenance of the 3D genome显示文摘Eukaryotic genomes are densely packaged into hierarchical three-dimensional(3D) structures that contain information about gene regulation and many other biological processes. With the development of imaging and sequencing-based technologies, 3D genome studies have revealed that the high-order chromatin structure is composed of hierarchical levels, including chromosome territories, A/B compartments, topologically associated domains, and chromatin loops. However, how this chromatin architecture is formed and maintained is not completely clear. In this review, we introduce experimental methods to investigate the 3D genome, review major architectural proteins that regulate 3D chromatin organization in mammalian cells, such as CTCF(CCCTC-binding factor), cohesin, lamins, and transcription factors, and discuss relevant mechanisms such as phase separation. | Mengfan Li Jingbo Gan Yuao Sun Zihan Xu Junsheng Yang Yujie Sun Cheng Li | 2020 | Science China(Life Sciences)2020，63，6： | 7 |
| 4 | Searching for the Nano-Hertz Stochastic Gravitational Wave Background with the Chinese Pulsar Timing Array Data ReleaseⅠ显示文摘Observing and timing a group of millisecond pulsars with high rotational stability enables the direct detection of gravitational waves(GWs).The GW signals can be identified from the spatial correlations encoded in the times-of-arrival of widely spaced pulsar-pairs.The Chinese Pulsar Timing Array(CPTA)is a collaboration aiming at the direct GW detection with observations carried out using Chinese radio telescopes.This short article serves as a“table of contents”for a forthcoming series of papers related to the CPTA Data Release 1(CPTA DR1)which uses observations from the Five-hundred-meter Aperture Spherical radio Telescope.Here,after summarizing the time span and accuracy of CPTA DR1,we report the key results of our statistical inference finding a correlated signal with amplitude logA_(c)=-14.4_(-2.8)^(+1.0)for spectral index in the range ofα∈[-1.8,1.5]assuming a GW background(GWB)induced quadrupolar correlation.The search for the Hellings–Downs(HD)correlation curve is also presented,where some evidence for the HD correlation has been found that a 4.6σstatistical significance is achieved using the discrete frequency method around the frequency of 14 n Hz.We expect that the future International Pulsar Timing Array data analysis and the next CPTA data release will be more sensitive to the n Hz GWB,which could verify the current results. | Heng Xu Siyuan Chen Yanjun Guo Jinchen Jiang Bojun Wang Jiangwei Xu Zihan Xue RNicolas Caballero Jianping Yuan Yonghua Xu Jingbo Wang Longfei Hao Jingtao Luo Kejia Lee Jinlin Han Peng Jiang Zhiqiang Shen Min Wang Na Wang Renxin Xu Xiangping Wu Richard Manchester Lei Qian Xin Guan Menglin Huang Chun Sun Yan Zhu | 2023 | Research in Astronomy and Astrophysics2023，23，7： | 3 |
| 5 | A highly active VOx-MnOx/CeO_(2) for selective catalytic reduction of NO:The balance between redox property and surface acidity显示文摘Excellent catalysts with low-temperature activity and relatively wide temperature window for selective catalytic reduction of NO with ammonia(NH_(3)-SCR) are highly demanded in view of the practical treatment of NO.Herein,we have designed a highly active VOx-MnOx/CeO_(2) material based on the intrinsic requirement of SCR reaction for catalyst,namely redox sites and surface acid sites.The vanadium oxide and manganese oxide are highly dispersed over the ceria mesosphere via simple incipient wetness impregnation.The loading of manganese could introduce acid sites and enhance the redox property remarkably,while the loading of vanadium increases acid sites and weakens redox property.Through tentatively controlling the appropriate loading ratio of the two components,the optimal catalyst achieves a balance between redox property and surface acidity.The work shed light on the development of new SCR catalyst with superior low temperature activity,wide work temperature window and good hydrothermal stability. | Runnong Yang Zihan Gao Ming Sun Guangying Fu Gao Cheng Wuyuan Liu Xiaobo Yang Xiangyun Zhao Lin Yu | 2021 | Journal of Rare Earths2021，39，11： | 3 |
| 6 | Application of Indoor Natural Ventilation Simulation in Residential Space Layout显示文摘Tatural ventilation of indoor air flow and thermal comfort space plays an important role, especial y in the interior design of passive cooling factors, indoor space layout, and the location of doors, windows and other factors on the indoor natural ventilation effect has great influence. Using the method of fluid mechanics, and Airpak3.0 software, indoor natural ventilation for residential buildings was simulated, and the thermal comfort of indoor natural ventilation in a residential building in Xuzhou City was analyzed to explore the effect of indoor spatial layout, location of doors, window opening types on indoor natural ventilation. The results showed that indoor spatial layout played an essential role in indoor natural ventilation, application of numerical simulation for the simulation of the indoor natural ventilation and assessment of indoor natural ventilation effect was a scientific instruction for the indoor spatial design. | SUN Bo WU Zihan JI Xiang LIANG Xinbin | 2019 | Journal of Landscape Research2019，11，2： | 1 |
| 7 | KRAS mutation-induced EndMT of brain arteriovenous malformation is mediated through the TGF-β/BMP-SMAD4 pathway显示文摘Objective Somatic KRAS mutations have been identified in the majority of brain arteriovenous malformations(bAVMs),and subsequent in vivo experiments have confirmed that KRAS mutation in endothelial cells(ECs)causes AVMs in mouse and zebrafish models.Our previous study demonstrated that the KRASG12D mutant independently induced the endothelial-mesenchymal transition(EndMT),which was reversed by treatment with the lipid-lowering drug lovastatin.However,the underlying mechanisms of action were unclear.Methods We used human umbilical vein ECs(HUVECs)overexpressing the KRASG12D mutant for Western blotting,quantitative real-time PCR,and immunofluorescence and wound healing assays to evaluate the EndMT and determine the activation of downstream pathways.Knockdown of SMAD4 by RNA interference was performed to explore the role of SMAD4 in regulating the EndMT.BAVM ECs expressing the KRASG12D mutant were obtained to verify the SMAD4 function.Finally,we performed a coimmunoprecipitation assay to probe the mechanism by which lovastatin affects SMAD4.Results HUVECs infected with KRASG12D adenovirus underwent the EndMT.Transforming growth factor beta(TGF-β)and bone morphogenetic protein(BMP)signalling pathways were activated in the KRASG12D-mutant HUVECs and ECs in bAVM tissue.Knocking down SMAD4 expression in both KRASG12D-mutant HUVECs and ECs in bAVM tissues inhibited the EndMT.Lovastatin attenuated the EndMT by downregulating p-SMAD2/3,p-SMAD1/5 and acetylated SMAD4 expression in KRASG12D-mutant HUVECs.Conclusions Our findings suggest that the KRASG12D mutant induces the EndMT by activating the ERK-TGF-β/BMP-SMAD4 signalling pathway and that lovastatin inhibits the EndMT by suppressing TGF-β/BMP pathway activation and SMAD4 acetylation. | Hongyuan Xu Ran Huo Hao Li Yuming Jiao Jiancong Weng Jie Wang Zihan Yan Junze Zhang Shaozhi Zhao Qiheng He Yingfan Sun Shuo Wang Yong Cao | 2023 | Stroke & Vascular Neurology2023，8，3： | 1 |
| 8 | Influence and experiment of cable-net manufacturing errors on surface accuracy of mesh reflector antennas显示文摘Cable-net structures are of substantial importance in the construction of large mesh reflector antennas.Owing to the inevitable errors in their manufacturing process,the reflector surface accuracy deteriorates.This study makes a comprehensive investigation of random manufacturing errors during constructing the mesh reflector antennas,and analyze its influence on reflector surface accuracy.Firstly,the sensitivity of reflector surface accuracy with respect to the random errors of the unstressed cable length is mathematically deducted.Secondly,a non-button connecting method is proposed and analyzed to reduce manufacturing errors.Thirdly,two physical experiment models based on 2.62-meter mesh reflector antenna are made.Finally,numerical examples and experimental tests are given to demonstrate the effectiveness of the proposed method.Compared with the traditional method,the proposed method can effectively reduce the influence of the manufacturing errors on the reflector surface accuracy.Moreover,the reduction in the sizes of the nodes also reduces the risk of entanglement of the mesh reflector antenna during the deployment process,and thereby improves the deployment reliability. | Zihan SUN Baoyan DUAN Yiqun Zhang Dongwu YANG | 2023 | Chinese Journal of Aeronautics2023，36，2： | 0 |
| 9 | Protective effects of blueberry anthocyanin extracts on hippocampal neuron damage induced by extremely low-frequency electromagnetic field显示文摘The protective effects of blueberry anthocyanin extracts against damage induced by extremely lowfrequency electromagnetic field(ELF-EMF)were investigated in a rat model.Wistar rats were exposed to ELF-EMF with or without the administration of blueberry anthocyanin extracts(50,100,and 200 mg/kg per day intragastrically once a day)for 30 days.Blueberry anthocyanin extracts supplementation inhibited the decrease in Nissl substance levels,cell membrane integrity,and mitochondrial membrane potential induced by ELF-EMF;prevented the increase in nitric oxide,malondialdehyde,and Ca2+concentrations;suppressed superoxide dismutase and glutathione depletion;and enhanced the cognitive ability of the rats exposed to ELF-EMF.The protective effects of blueberry anthocyanin extracts against hippocampal neuron injury caused by ELF-EMF were dose-dependent.These results demonstrated that blueberry anthocyanin extracts suppress hippocampal neuron injury caused by ELF-EMF by inhibiting cell membrane damage and oxidative stress pathways,and suggested that blueberry anthocyanin treatment potentially prevents hippocampal neuron injury. | Xiyun Sun Zihan Xu Yuehua Wang Ning Liu | 2020 | Food Science and Human Wellness2020，9，3： | 0 |
| 10 | A likely autotetraploidization event shaped the Chinese mahogany(Toona sinensis)genome显示文摘Chinese mahogany(Toona sinensis) is of considerable medical and economic importance, and its genome has been deciphered. However, the process underlying its polyploidy is unclear, and the chromosomal evolutionary trajectory is poorly understood. Here, by reanalysing the T.sinensis genome, we found evidence of a tetraploidization event(T. sinensis special tetraploidization, TST) that occurred approximately 15-17 million years ago(MYA) after the core eudicot-common hexaploidization(ECH or gamma) event. We characterized the synonymous nucleotide substitution rates(Ks values) of collinear genes and found that T. sinensis genes affected by the TST evolve at a slower rate than Acer yangbiense genes. Furthermore, we identified homologous genes related to polyploidization and speciation and constructed multiple alignments with different reference genomes. Notably, the significant balance of gene retention and loss characterized in the two TST-derived subgenomes suggests an autopolyploid nature of the TST. Moreover, we deduced the chromosomal karyotypes of the two subgenomes and identified 7chromosomal fusions that have shaped the T. sinensis genome;more information is available on a newly constructed karyotype platform(http://gffzze84c5b42976d4cd7hwcv0fubkbu9n6n5x.ffgz.tsg.suse.edu.cn/Toona_sinensis/index.html). The T. sinensis genome preserves the ancestral chromosome structure of dicotyledons well and could serve as a good reference for understanding genomic changes in other Meliaceae and Sapindales plants. In addition, we verified that tandem duplication and the ECH have promoted the expansion of terpene synthase(TPS) genes;conversely, the TST seems to have inhibited expansion of these genes. This present effort has clarified the polyploidy events of the T. sinensis genome, filled gaps in the history of karyotype evolution, and laid a solid foundation for further genomic studies in the Meliaceae research community and beyond. | Jianyu Wang Ziyi Yang Tianyu Lei Yan Zhang Qimeng Xiao Zijian Yu Jiaqi Zhang Sangrong Sun Qiang Xu Shaoqi Shen Zimo Yan Mengnan Fang Yue Ding Zihan Liu Qianwen Zhu Ke Ren Yuxin Pan Haibin Liu Jinpeng Wang | 2023 | Horticultural Plant Journal2023，9，2： | 0 |
| 11 | Two-dimensional ferromagnetic superlattices显示文摘Mechanically exfoliated two-dimensional ferromagnetic materials(2D FMs)possess long-range ferromagnetic order and topologically nontrivial skyrmions in few layers.However,because of the dimensionality effect,such few-layer systems usually exhibitmuch lower Curie temperature(TC)compared to their bulk counterparts.It is therefore of great interest to explore effective approaches to enhance their TC,particularly in wafer-scale for practical applications.Here,we report an interfacial proximity-induced high-TC 2D FM Fe3GeTe2(FGT)via A-type antiferromagnetic material CrSb(CS)which strongly couples to FGT.A superlattice structure of(FGT/CS)n,where n stands for the period of FGT/CS heterostructure,has been successfully produced with sharp interfaces by molecular-beam epitaxy on 2-inch wafers.By performing elemental specific X-ray magnetic circular dichroism(XMCD)measurements,we have unequivocally discovered that TC of 4-layer Fe3GeTe2 can be significantly enhanced from 140 K to 230 K because of the interfacial ferromagnetic coupling.Meanwhile,an inverse proximity effect occurs in the FGT/CS interface,driving the interfacial antiferromagnetic CrSb into a ferrimagnetic state as evidenced by double-switching behavior in hysteresis loops and the XMCD spectra.Density functional theory calculations show that the Fe-Te/Cr-Sb interface is strongly FMcoupled and doping of the spin-polarized electrons by the interfacial Cr layer gives rise to the TC enhancement of the Fe3GeTe2 films,in accordance with our XMCDmeasurements.Strikingly,by introducing rich Fe in a 4-layer FGT/CS superlattice,TC can be further enhanced to near room temperature.Our results provide a feasible approach for enhancing the magnetic order of few-layer 2D FMs in wafer-scale and render opportunities for realizing realistic ultra-thin spintronic devices. | Shanshan Liu Ke Yang Wenqing Liu Enze Zhang Zihan Li Xiaoqian Zhang Zhiming Liao Wen Zhang Jiabao Sun Yunkun Yang Han Gao Ce Huang Linfeng Ai Ping Kwan Johnny Wong Andrew Thye Shen Wee Alpha TN’Diaye Simon AMorton Xufeng Kou Jin Zou Yongbing Xu Hua Wu Faxian Xiu | 2020 | National Science Review2020，7，4： | 0 |
| 12 | Coupling interface constructions of hollow Co-Mo mixed multiple oxidation states heterostructure for high-performance aprotic Li-O_(2) battery显示文摘Constructing interfaces in heterostructures is effective for modulating the electronic properties of electrocatalysts.The hollow CoMoO_(4)-Co_(3)O_(4) heterostructure(HCMCH)was prepared as a bifunctional electrocatalyst for Li-O_(2) battery.The different components in CoMoO_(4)-Co_(3)O_(4) heterostructure presented the efficient coupling and enhanced the electrocatalytic activity for aprotic oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),in which it improved the obviously reduced overpotential of 300 mV(compared with the pure Ketjen black(KB)electrode),enhanced reversibility of 80%capacity retention after 6 full cycles and the superior cyclability of more than 200 cycles with an optimized strategy.The battery performance of the HCMCH was not only associated with the unique hollow structure and rich active sites but also with coupling interface constructions synergetic effects attaching to the improving conductivity and optimized the discharge conversion.These results suggested that this HCMCH electrocatalyst was a promising candidate for the Li-O_(2) battery and it gave a novel insight for high performance electrocatalyst designing. | Xingzi Zheng Mengwei Yuan Jingshen Xu Zihan Li Caiyun Nan Genban Sun | 2024 | Nano Research2024，17，5： | 0 |
| 13 | Dopamine in the prefrontal cortex plays multiple roles in the executive function of patients with Parkinson's disease显示文摘Parkinson’s disease can affect not only motor functions but also cognitive abilities,leading to cognitive impairment.One common issue in Parkinson’s disease with cognitive dysfunction is the difficulty in executive functioning.Executive functions help us plan,organize,and control our actions based on our goals.The brain area responsible for executive functions is called the prefrontal co rtex.It acts as the command center for the brain,especially when it comes to regulating executive functions.The role of the prefrontal cortex in cognitive processes is influenced by a chemical messenger called dopamine.However,little is known about how dopamine affects the cognitive functions of patients with Parkinson’s disease.In this article,the authors review the latest research on this topic.They start by looking at how the dopaminergic syste m,is alte red in Parkinson’s disease with executive dysfunction.Then,they explore how these changes in dopamine impact the synaptic structure,electrical activity,and connection components of the prefrontal cortex.The authors also summarize the relationship between Parkinson’s disease and dopamine-related cognitive issues.This information may offer valuable insights and directions for further research and improvement in the clinical treatment of cognitive impairment in Parkinson’s disease. | Zihang Zhou Yalong Yan Heng Gu Ruiao Sun Zihan Liao Ke Xue Chuanxi Tang | 2024 | Neural Regeneration Research2024，19，8： | 0 |
| 14 | Expert Guidance on the Overall Management of Liver Cancer During the COVID-19 Pandemic显示文摘The COVID-19 pandemic remains complex,with concentrated and sporadic cases in multiple locations.During COVID-19 outbreaks,the routine diagnosis and treatment of liver cancer patients can be affected to a significant degree.For liver oncologists,it is important to identify strategies and protocols to reduce the risk of COVID-19 infection among patients and medical staff,use limited medical resources to maximally ensure access to anti-tumor treatment and related emergency treatment,and provide support for patients during the disruption caused by the pandemic.Given this requirement,eleven experts in liver cancer treatment-related disciplines from Zhongshan Hospital,Fudan University have written the Expert Guidance on the Overall Management of Liver Cancer During the COVID-19 Pandemic,which aims to provide a reference to assist liver oncologists in conducting clinical work safely and effectively while implementing COVID-19 prevention and control strategies and offer guidance on supporting liver cancer patients during the pandemic. | Huichuan SUN Xinrong YANG Zhiping YAN Zhenggang REN Rong LIU Lan ZHANG Yang XU Yifeng HE Zihan ZHANG Jia FAN Jian ZHOU | 2022 | Clinical Cancer Bulletin2022，1，2： | 0 |
| 15 | Analysis of Cloning and Expression Characteristics of Capsicum chinense Jacq. CcMYB Gene显示文摘In order to discuss the role of MYB gene in capsaicine synthesis process,one CcMYB gene was cloned from Capsicum chinense Jacq. by RT-PCR. Its cDNA has a total length of 1 038 bp,and was speculated to code 345 amino acids,comprising an complete open reading frame. The isoelectric point is 8. 57,and the molecular weight is 38. 2 KD. The protein is a neutral hydrophobin without transmembrane structure. There are two MYBDNA domains at the N terminal. The fluorescence quantitative PCR results showed that CcMYB gene was expressed in all the root,stem,leaf,flower,placenta and fruit tissue of pepper,and the expression level was the highest in fruit; and CcM YB was expressed in fruit at the highest level at turning stage,and at the second highest level at expansion stage,which accords with the expression profile of pun1 gene in fruit development period. It is speculated that CcMYB gene plays an important role in the regulation of capsaicine synthesis in C. chinense fruit. | Ziqi ZHAO Yucen GUO Wanying ZHANG Zihan LI Haoyun SUN Chunyu ZHANG Jingying WANG Qingxun GUO | 2018 | Agricultural Biotechnology2018，7，4： | 0 |
| 16 | Status Quo of Maker Spaces in Main Urban Area of Chengdu显示文摘This paper, based on the literature review and field investigation, studied the status quo of maker spaces in main urban district of Chengdu at a time when the development of the maker spaces has received strong support from national and local governments. In addition to introducing the related concepts and policy support of the maker space, it summarized its distribution characteristics, audience characteristics, and status quo as well as problems and presented the direction for the development of the maker space in main urban area of Chengdu grounded on a survey of the status quo of national maker spaces in main urban area of Chengdu. | GAO Wei LIU Pan LIANG Zihan HOU Junzheng LUO Tianze LU Baorong WANG Xufei YU Xinyu FENG Yajin REN Zijie DU Jinqiang BAI Yile WANG Kejie SUN Zhentong | 2017 | Journal of Landscape Research2017，9，4： | 0 |
| 17 | The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry显示文摘The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is achieved in the nucleus.We report here the identification of a nonclassical TCA cycle in the nucleus(nTCA cycle).We found that all the TCA cycle-associated enzymes including citrate synthase(CS),aconitase 2(ACO2),isocitrate dehydrogenase 3(IDH3),oxoglutarate dehydrogenase(OGDH),succinyl-CoA synthetase(SCS),fumarate hydratase(FH),and malate dehydrogenase 2(MDH2),except for succinate dehydrogenase(SDH),a component of electron transport chain for generating ATP,exist in the nucleus.We showed that these nuclear enzymes catalyze an incomplete TCA cycle similar to that found in cyanobacteria.We propose that the nTCA cycle is implemented mainly to generate/consume metabolic intermediates,not for energy production.We demonstrated that the nTCA cycle is intrinsically linked to chromatin dynamics and transcription regulation.Together,our study uncovers the existence of a nonclassical TCA cycle in the nucleus that links the metabolic pathway to epigenetic regulation. | Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang Luyang Sun Yongfeng Shang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 18 | Tuning 2D magnetism in Fe_(3+X)GeTe_(2) films by element doping显示文摘Two-dimensional(2D)ferromagnetic materials have been discovered with tunable magnetism and orbital-driven nodal-line features.Controlling the 2D magnetism in exfoliated nanoflakes via electric/magnetic fields enables a boosted Curie temperature(T_(C))or phase transitions.One of the challenges,however,is the realization of high T_(C) 2D magnets that are tunable,robust and suitable for large scale fabrication.Here,we report molecular-beam epitaxy growth of wafer-scale Fe_(3+X)GeTe_(2) films with T_(C) above room temperature.By controlling the Fe composition in Fe_(3+X)GeTe_(2),a continuously modulated T_(C) in a broad range of 185–320 K has been achieved.This widely tunable TC is attributed to the doped interlayer Fe that provides a 40%enhancement around the optimal composition X=2.We further fabricated magnetic tunneling junction device arrays that exhibit clear tunneling signals.Our results show an effective and reliable approach,i.e.element doping,to producing robust and tunable ferromagnetism beyond room temperature in a large-scale 2D Fe_(3+X)GeTe_(2) fashion. | Shanshan Liu Zihan Li Ke Yang Enze Zhang Awadhesh Narayan Xiaoqian Zhang Jiayi Zhu Wenqing Liu Zhiming Liao Masaki Kudo Takaaki Toriyama Yunkun Yang Qiang Li Linfeng Ai Ce Huang Jiabao Sun Xiaojiao Guo Wenzhong Bao Qingsong Deng Yanhui Chen Lifeng Yin Jian Shen Xiaodong Han Syo Matsumura Jin Zou Yongbing Xu Xiaodong Xu Hua Wu Faxian Xiu | 2022 | National Science Review2022，9，6： | 0 |
| 19 | Chemical Strain of Graphite-Based Anode during Lithiation and Delithiation at Various Temperatures显示文摘Electrochemical lithiation/delithiation of electrodes induces chemical strain cycling that causes fatigue and other harmful influences on lithium-ion batteries.In this work,a homemade in situ measurement device was used to characterize simultaneously chemical strain and nominal state of charge,especially residual chemical strain and residual nominal state of charge,in graphite-based electrodes at various temperatures.The measurements indicate that raising the testing temperature from 20℃ to 60℃ decreases the chemical strain at the same nominal state of charge during cycling,while residual chemical strain and residual nominal state of charge increase with the increase of temperature.Furthermore,a novel electrochemicalmechanical model is developed to evaluate quantitatively the chemical strain caused by a solid electrolyte interface(SEI)and the partial molar volume of Li in the SEI at different temperatures.The present study will definitely stimulate future investigations on the electro-chemo-mechanics coupling behaviors in lithium-ion batteries. | Zeyu Xu Xiuling Shi Xiaoqiang Zhuang Zihan Wang Sheng Sun Kaikai Li Tong-Yi Zhang | 2022 | Research2022，，1： | 0 |
| 20 | 2T1C DRAM based on semiconducting MoS_(2) and semimetallic graphene for in-memory computing显示文摘In-memory computing is an alternative method to effectively accelerate the massive data-computing tasks of artificial intelligence(AI)and break the memory wall.In this work,we propose a 2T1C DRAM structure for in-memory computing.It integrates a monolayer graphene transistor,a monolayer MoS_(2)transistor,and a capacitor in a two-transistor-onecapacitor(2T1C)configuration.In this structure,the storage node is in a similar position to that of one-transistor-one-capacitor(1T1C)dynamic random-access memory(DRAM),while an additional graphene transistor is used to accomplish the nondestructive readout of the stored information.Furthermore,the ultralow leakage current of the MoS_(2)transistor enables the storage of multi-level voltages on the capacitor with a long retention time.The stored charges can effectually tune the channel conductance of the graphene transistor due to its excellent linearity so that linear analog multiplication can be realized.Because of the almost unlimited cycling endurance of DRAM,our 2T1C DRAM has great potential for in situ training and recognition,which can significantly improve the recognition accuracy of neural networks. | Saifei Gou Yin Wang Xiangqi Dong Zihan Xu Xinyu Wang Qicheng Sun Yufeng Xie Peng Zhou Wenzhong Bao | 2023 | National Science Open2023，2，4： | 0 |
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