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| 1 | Seasonality in human semen quality of smokers and non-smokers: effect of temperature显示文摘Aim: To analyse the possible effect of seasonal variation on semen parameters. Methods: The participants consisted of 1688 men attending the andrology laboratory between 1991 and 1997 for reduced fertility in the couple. Semen analysis was performed according to the WHO manual. The 84 individual months of the study period were each assigned to one of the three groups according to the average monthly outside temperature; Group A (temperature <4.4 ℃), Group B (4.4 ℃ - 13.3 ℃) and Group C (>13.3 ℃). Results: When comparing the different sperm parameters, the morphology was significantly better in Group C. However, when the smokers were analysed separately, this difference disappeared and significant seasonal variations were found in sperm density, total sperm count, motility and total motile sperm; they were deteriorated in the warmer season. In non-smokers, no such negative effect of increased temperature was observed. Conclusion: Sperm quality is influenced by seasonal factors.Increased environmental temperature, (maybe also light exposure) has an additional negative effect on the spermatogenesis in smokers, leading to reduced sperm quality in men with borderline fertility. (Asian J Androl 2004 Sep; 6:243-247) | Robert Kunzle Michael D.Mueller Alexander W.Huber Heinz Drescher Nick A.Bersinger | 2004 | Asian Journal of Andrology2004，6，3： | 5 |
| 2 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 3 | Systematic review of mini-implant displacement under orthodontic loading显示文摘A growing number of studies have reported that mini-implants do not remain in exactly the same position during treatment, although they remain stable. The aim of this review was to collect data regarding primary displacement immediately straight after loading and secondary displacement over time. A systematic review was performed to investigate primary and secondary displacement. The amount and type of displacement were recorded. A total of 27 studies were included. Sixteen in vitro studies or studies using finite element analysis addressed primary displacement, and nine clinical studies and two animal studies addressed secondary displacement. Significant primary displacement was detected(6.4–24.4 mm) for relevant orthodontic forces(0.5–2.5 N). The mean secondary displacement ranged from 0 to 2.7 mm for entire mini-implants. The maximum values for each clinical study ranged from 1.0 to 4.1 mm for the head, 1.0 to 1.5 for the body and 1.0 to 1.92 mm for the tail part. The most frequent type of movement was controlled tipping or bodily movement. Primary displacement did not reach a clinically significant level. However, clinicians can expect relevant secondary displacement in the direction of force. Consequently, decentralized insertion within the inter-radicular space, away from force direction, might be favourable. More evidence is needed to provide quantitative recommendations. | Manuel Nienkemper Jrg Handschel Dieter Drescher | 2014 | International Journal of Oral Science2014，6，1： | 2 |
| 4 | Predicting High-Risk Behaviors in Veterans With Posttraumatic Stress Disorder显示文摘 | Tamara L. Hartl Craig Rosen Kent Drescher Tina T. Lee Fred Gusman | 2005 | The Journal of Nervous and Mental Disease2005，，： | 2 |
| 5 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTHW H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 6 | The dopamine D3 recep-tor plays an essential role in alcohol-seeking and relapse显示文摘 | Vengeliene V Leonardi-Essmann F Perreau-Lenz S Gebicke-Haerter P Drescher K Gross G | 2006 | FASEB J2006，20，13： | 1 |
| 7 | Combining CA 125 and SMR serum markers for diagnosis and early detection of ovarian carcinoma显示文摘 | McIntosh MW Drescher C Karlan B | 2004 | Gynecol Oncol2004，95，： | 1 |
| 8 | Slope stability analysis by strength reduction显示文摘 | DAWSON E M ROTH W H DRESCHER A | 1999 | Geotechnique1999，49，6： | 1 |
| 9 | A model for static liquefaction in triaxial compression and extension显示文摘 | MrózZ Boukpeti N Drescher A | 2002 | Canadian Geotechnical Journal2002，，6： | 1 |
| 10 | Interaction of two actinbinding proteins, synaptopodin and alpha -actinin -4, with the tight junction protein MAGI -l显示文摘 | PATR/E K M DRESCHER A J WELIHINDA A | 2002 | J Biol Chem2002，277，30： | 1 |
| 11 | Topographic targeting andpathfinding errors of retinal axons following overexpression of ephri-nA ligands on retinal ganglion cell axons 显示文摘 | Du tting D Handwerker C Drescher U | 1999 | Dev Biol1999，216，1： | 1 |
| 12 | Stiffness es- timates using portable deflectometers 显示文摘 | Hoffmann O J M Guzina B B Drescher A | 2004 | Transporta- tion Research Record2004，，1869： | 1 |
| 13 | Bearing capacity of circular footings显示文摘 | Erickson H L Drescher A | 2002 | Journal of Geotechnical and Geoenvironmental Engineering2002，128，1： | 1 |
| 14 | Limit load in translational failure mechanisms for associated and nonassociated materials显示文摘 | DRESCHER A DETOURNAY C | 1993 | Geotechnique1993，43，3： | 1 |
| 15 | Methylprednisolone enhances contraction of porcine femoral head epiphyseal arteries显示文摘 | Drescher W Būnger MH Weigert K | 2004 | Clin Orthop Relat Res2004，423，： | 1 |
| 16 | Impact of bone quality, implant type, and implantation site preparation on insertion torques of mini-implants used for orthodontic anchorage 显示文摘 | Wihnes B Drescher D | 2011 | Int J Oral Maxillofac Surg2011，40，7： | 1 |
| 17 | Superior mesenteric artery aneurysm stent graft显示文摘 | R. Drescher O. K?ster T. Rothenburg | 2006 | Abdominal Imaging2006，，1： | 1 |
| 18 | A vertically sensitive accelerometer and its realisation by depth UV lithography supported electroplating显示文摘 | QU W WENZEL C DRESCHER K | 2000 | Microelectronics journal2000，31，7： | 1 |
| 19 | Is helical blade nail-ing superior to locked minimally invasive plating in unstablepertrochanteric fractures显示文摘 | Knobe M Drescher W Heussen N | 2012 | Clin Orthop Relat Res2012，47，28： | 1 |
| 20 | The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD56+ natural killer cells显示文摘 | Drescher S van der Kuip H | 2001 | Pharmacogenetics2001，11，： | 1 |
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