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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 早期的硫化物饱和并不妨碍斑岩Cu-Au矿的形成显示文摘斑岩型铜(金和钼)矿床提供了世界上约75%的Cu、50%的Mo和20%的Au的产量。该类型矿床通常与汇聚板块边缘的下地壳以及中性火山-侵入岩浆体系相关。然而,尽管经过近十年的研究,目前对造成富矿岩浆体系和贫矿岩浆体系的控制因素仍然不完全清楚。一些研究认为,富矿岩浆比贫瘠岩浆更加富集金属成矿元素,而另一些研究则指出,斑岩型铜矿可以通过正常岩浆形成,并指出岩浆的硫含量、氧逸度、水含量或者上地壳岩浆房的规模都能决定其成矿。 | Du J G Audétat A 袁超(编译) | 2020 | 矿物岩石地球化学通报2020，39，3： | 5 |
| 3 | Iron in the NEEM ice core relative to Asian loess records over the last glacial–interglacial cycle显示文摘Mineral dust can indirectly affect the climate by supplying bioavailable iron(Fe)to the ocean.Here,we present the records of dissolved Fe(DFe)and total Fe(TDFe)in North Greenland Eemian Ice Drilling(NEEM)ice core over the past 110 kyr BP.The Fe records are significantly negatively correlated with the carbon-dioxide(CO_(2))concentrations during cold periods.The results suggest that the changes in Fe fluxes over the past 110 kyr BP in the NEEM ice core are consistent with those in Chinese loess records because the mineral-dust distribution is controlled by the East Asian deserts.Furthermore,the variations in the dust input on a global scale are most likely driven by changes in solar radiation during the last glacial–interglacial cycle in response to Earth’s orbital cycles.In the last glacial–interglacial cycle,the DFe/TDFe ratios were higher during the warm periods(following the post-Industrial Revolution and during the Holocene and last interglacial period)than during the main cold period(i.e.the last glacial maximum(LGM)),indicating that the aeolian input of iron and the iron fertilization effect on the oceans have a non-linear relationship during different periods.Although the burning of biomass aerosols has released large amounts of DFe since the Industrial Revolution,no significant responses are observed in the DFe and TDFe variations during this period,indicating that severe anthropogenic contamination has no significant effect on the DFe(TDFe)release in the NEEM ice core. | Cunde Xiao Zhiheng Du Mike J Handley Paul A Mayewski Junji Cao Simon Schüpbach Tong Zhang Jean-Robert Petit Chuanjin Li Yeongcheol Han Yuefang Li Jiawen Ren | 2021 | National Science Review2021，8，7： | 2 |
| 4 | The nuclear localization of NF-kappa B and p53 is positively correlated with HPV16 E7 level in laryngeal squamous cell carcinoma显示文摘 | Du J Chen GG Vlantis A | 2003 | J Histochem Cytochem2003，51，4： | 2 |
| 5 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 6 | A quantitative screening of some xylose fermenting yeast isolates 显示文摘 | Du Preez J C Prior B A | 1985 | Biotechnol Lett1985，7，： | 1 |
| 7 | Oxygen consumption of a shallow water teleost the spotted gunter,Pomadasys commersonni显示文摘 | DU PREEZE H H MCLACHLAN A MARAIS J | 1986 | Comp Biochem Physiol1986，84，： | 1 |
| 8 | Structural investigations of Fe-Ga alloys: Phase relations and magnetostrictive behavior 显示文摘 | XING Q DU Y MCQUEENEY R J LOGRASSO T A | 2008 | Acta Materialia2008，56，16： | 1 |
| 9 | 显示文摘 | Zhang X W Pan J H Du A J | 2009 | Water Res2009，43，5： | 1 |
| 10 | Contemporary evidence on the physiological role of reactive oxygen species in human sperm function显示文摘 | Du Plessis SS Agarwal A Halabi J | 2015 | J Assist Reprod Genet2015，32，： | 1 |
| 11 | Urinary excretion of beta 2-microglobulin and IgG predict prognosis in idiopathic membranous nephropathy : a validation study 显示文摘 | BRANTEN A J DU BUF-VEREIJKEN P W KLASEN I S | 2005 | J Am Soc Nephrol2005，16，1： | 1 |
| 12 | Technique for rapid in vitro single-cell elastography 显示文摘 | Ebert A Tittmann B R Du J Scheuchenzuber W | 2006 | Ultrasound in Medicine and Biology2006，32，11： | 1 |
| 13 | Attitudes of ranchers to- wards African wild dogs Lycaon pictus: Conservation implications on private land 显示文摘 | Lindsey P A du Toit J T Mills M G L | 2005 | Biological Conservation2005，125，1： | 1 |
| 14 | Separation of Nickel and Calci- um by Solvent Extraction Using Mixtures of Carboxylic Acids and Alkylpyridines显示文摘 | Preston J S Du Preez A C | 2000 | Hydrometallurgy2000，58，3： | 1 |
| 15 | The anti-idiotypie antibody abagovomab in patients with recurrent ovarian cancer,A phase I trial of the AGO-OVAR显示文摘 | Pfisterer I Du Bois A Sehouli J | | 0，，： | 1 |
| 16 | Host plants and natural enemies of Bemisia tabaci (Homoptera:Aleyrodidae) in China显示文摘 | LiS J Xue X Ahmed M Z Ren S X Du Y Z Wu J H Cuthbertson A G S and Qiu B L | | 0，，： | 1 |
| 17 | Development and optimization of a process for automated recovery of single cells identified by microengraving 显示文摘 | Choi J H Ogunniyi A O Du M | 2010 | Biotechnol Prog2010，26，3： | 1 |
| 18 | Mechanics of toughening brittle polymers显示文摘 | Thouless M D Du J Yee A F | 2000 | ACS Symposium Series2000，759，5： | 1 |
| 19 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
| 20 | Production of ethanol from sugar cane bagasse hemicellulose hydrolyzate by Pichia stipitis显示文摘 | Van Zyl C Prior B A Du Preez J C | 1988 | Appl Biochem Biotechnol1988，17，13： | 1 |
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