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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | Seasonal variations and sources of mass and chemical composition for PM_(10) aerosol in Hangzhou,China显示文摘Aerosol observation was conducted for four seasons from September 2001 to August 2002 at five sampling sites in Hangzhou, South China, on PM10 mass, 22 elements (Na, Mg, Al, Si, P, S, K, Ca, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Br, Cd, Ba, and Pb), 5 major ions (F-, Cl-, NO3-, SO42-, and NH4+), and organic and elemental carbon (OC and EC), showing that PM10 mass ranged from 46.7 to 270.8 g/m3, with an annual average of 119.2 g/m3. Na, Al, Si, S, K, Ca, and Fe were the most abundant elements in PM10, most of S being in the form of SO42-. SO42-, NO3-, and NH4+ were the major ions, which contributed to about 20% of the PM10 mass. The mean seasonal concentrations for SO42-, averaged over all sites, were found to be 18.0, 18.5, 24.7, and 21.4 g/m3, for spring, summer, autumn, and winter, respectively, while the corresponding loadings for NO3- were 7.2, 4.7, 7.1, and 11.2 g/m3, and for NH4+ were 6.0, 5.9, 8.2, and 9.3 g/m3, in the form mostly of NH4NO3 in spring, autumn, and winter, and mostly of (NH4)2SO4 in summer. The low NO3-/SO42-ratio found indicates coal combustion as the major source throughout the year. The mean annual concentrations of OC and EC in PM10 were found to be 21.4, and 4.1 g/m3, respectively. Material balance calculation indicated that fugitive dust, the secondary aerosol, and carbonaceous matter were the most abundant species in PM10 for the four seasons, as is characteristic for cities in South China. | Junji Cao Zhenxing Shen Judith C. Chow Guowei Qi John G. Watson | 2009 | Particuology2009，7，3： | 58 |
| 3 | Evolution of planetary boundary layer under different weather conditions,and its impact on aerosol concentrations显示文摘一个领域实验在天津被进行,从 2010 年 9 月 930 日的中国,在表面空气污染物质上集中了于行星的边界层(PBL ) 和它的影响的进化。实验使用了三台遥感仪器,风侧面雷达( WPR ),微波辐射计( MWR )和微脉搏的激光雷达( MPL ),到检测风,温度,和喷雾器 backscattering 系数并且到的垂直侧面测量表面污染物质的垂直侧面(喷雾器,公司, SO2 , NOx ),并且也从 255-m 收集了声音的风速表数据气象学的塔。把大小基于这些, PBL 的进化被估计。平均 PBL 高度在夜间期间在 noon/afternoon-time,和 200300 m 期间是大约 10001300 m。PBL 高度和喷雾器集中是相关反的在期间清楚并且薄雾条件。当平均喷雾器集中分别地是在薄雾和晴朗天空条件下面的 52 和 17 g/m3 时,平均最大的 PBL 高度是 1.08 和 1.70 km。太阳的放射上的喷雾器和云的影响基于从 255-m 收集的声音的风速表数据被观察气象学的塔。当 PBL 的镇压结构进一步削弱了污染物质的散开时,热流动被发现被薄雾(重污染) 或云显著地减少了,它趋于压抑 PBL 的发展,导致重污染。这个可能的积极反馈周期(更多的喷雾器降低 PBL 高度更多的喷雾器) 将在大城市为重地面污染导致一个加速过程。 | Jiannong Quan Yang Gao Qiang Zhang Xuexi Tie Junji Cao Suqin Han Junwang Meng Pengfei Chen Delong Zhao | 2013 | Particuology2013，11，1： | 51 |
| 4 | Aerosol pollution in China:Present and future impact on environment显示文摘With its dense population, rapid economic growth and dramatic rate of urbanization, China is experiencing extreme air pollution problems. This is particularly the case in Central-Eastern China (CEC), where the two major cities of Beijing and Tianjin are located, in the Yangtze-River Delta (YRD) with the city of Shanghai, and in the Pearl-River Delta (PRD) with the mega-city of Guangzhou. Space observations show that the atmospheric aerosol load in these three regions is considerably higher than, for example, in the urbanized regions of Europe and North America. The high aerosol concentrations in these regions have raised many environmental problems, such as impact on human health, visibility, and climate changes. In this paper, several crucial issues regarding aerosol pollution in these highly populated regions (CEC, YRD, and PRD) are discussed, including (1) when the aerosol load starts to rapidly increase in these regions; (2) how the high aerosol concentrations affects the environment; and (3) what the potential consequences are under possible low aerosol load in these regions. Discussion on these crucial issues might lead to some insight for better understanding of the characterizations of aerosol pollution due to the rapid economical development in China. | Xuexi Tie Junji Cao | 2009 | Particuology2009，7，6： | 48 |
| 5 | Chemical characteristics of PM_(2.5) during dust storms and air pollution events in Chengdu,China显示文摘每天好的微粒(PM2.5 ) 样品从 2009 年 4 月在 Chengdu 被收集到 2010 年 2 月在灰尘暴风雨(决策支持系统) 和污染事件的几种类型期间调查他们的化学侧面,包括薄雾(HD ) ,燃烧的生物资源(BB ) ,和焰火显示(FD ) 。最高的 PM2.5 集体集中在决策支持系统(283.3 g/m3 ) 期间被发现,列在后面由 FD (212.7 g/m3 ) , HD (187.3 g/m3 ) ,和 BB (130.1 g/m3 ) 。大多数元素的集中在决策支持系统和污染事件期间被提高,除了 BB。第二等的无机的离子(NO3, SO42,和 NH4+) 在 HD 期间被充实,当从 BB 的 PM2.5 显示出高 K+ 时但是低 SO42。FD 在 SO42 在 K+ 和丰富引起了增加。Ca2+ 充满 DS 样品。离子平衡计算从 HD 显示了那 PM2.5, FD 比在正常的天更酸,但是 DS 和 BB 粒子是碱的。最高器官的碳(OC ) 集中在 FD 期间是 26.1 g/m3,列在后面由 BB (23.6 g/m3 ) , HD (19.6 g/m3 ) ,和决策支持系统(18.8 g/m3 ) 。相反,元素的碳(EC ) 集中比在 BB (6.2 g/m3 ) 和决策支持系统(6.0 g/m3 ) 期间在 HD (10.6 g/m3 ) 和 FD (9.5 g/m3 ) 期间是更丰富的。最高的 OC/EC 比率在 BB 期间被获得,与在 HD 期间最低。SO42/K+ 和 TCA/SO42 比率证明了是为区分污染事件的有效指示物。集体平衡证明那有机物, SO42,和 NO3 在污染事件期间是主导的化学部件,当土壤灰尘在决策支持系统期间是主导的时。 | Qiyuan Wang Junji Cao Zhenxing Shen JunTao Shun Xiao Lei Luo Qingyang He Xinying Tang | 2013 | Particuology2013，11，1： | 23 |
| 6 | PM_(2.5)-bound polycyclic aromatic hydrocarbons(PAHs) in Beijing:Seasonal variations,sources,and risk assessment显示文摘Polycyclic aromatic hydrocarbons(PAHs) have been of health concern due to its carcinogenesis and mutagenesis. In this study, we aimed to assess the variations, sources, and lifetime excessive cancer risk(ECR) attributable to PAHs bound to ambient particulate matters with aerodynamic diameter less than 2.5 μm(PM_(2.5)) in metropolitan Beijing, China. We collected24-hour integrated PM_(2.5) samples on daily basis between November 2014 and June 2015 across both central heating(cold months) and non-heating(warm months) seasons, and further analyzed the PAH components in these daily PM_(2.5) samples. Our results showed that total concentrations of PM_(2.5)-bound PAHs varied between(88.6 ± 75.4) ng/m^3 in the cold months and(11.0 ± 5.9) ng/m^3 in the warm months. Benzo[a]pyrene(Ba P), the carcinogenic marker of PAHs,averaged at 5.7 and 0.4 ng/m^3 in the cold and warm months, respectively. Source apportionment analyses illustrated that gasoline, biomass burning, diesel, coal combustion and cooking were the major contributors, accounting for 12.9%, 17.8%, 24.7%, 24.3% and 6.4% of PM_(2.5)-bound PAHs, respectively. The BaP equivalent lifetime ECR from inhalation of PM_(2.5)-bound PAHs was 16.2 cases per million habitants. Our results suggested that ambient particulate reduction from energy reconstruction and adaption of clean fuels would result in reductions PM_(2.5)-bound PAHs and its associated cancer risks. However, as only particulate phased PAHs was analyzed in the present study, the concentration of ambient PAHs could be underestimated. | Baihuan Feng Lijuan Li Hongbing Xu Tong Wang Rongshan Wu Jie Chen Yi Zhang Shuo Liu Steven Sai Hang Ho Junji Cao Wei Huang | 2019 | Journal of Environmental Sciences2019，31，3： | 17 |
| 7 | Emissions of polycyclic aromatic hydrocarbons from coking industries in China显示文摘这研究开始估计多不的芳香的烃的特征(哼) 从 coking 工业的排放,与在四典型焦炭植物进行的领域采样。为每选择植物,栈烟道气体样品在包括的进程期间是镇定的控告煤进炉(CC ) ,推焦炭(PC ) 和焦炭炉气体(CG ) 的燃烧。十六个个人在 US EPA 优先级表上哼被煤气的层析 / 团 spectrometry (GC/MS ) 分析。结果证明总数哼在烟道气体的集中从 45.776 ~ 414.874 g/m3 ,与为 CC (359.545 g/m3 ) 的最高的排放水平。集中哼在 CP1 (收费的邮票) 从 CC 过程射出从 CP3 和 CP4 (收费的顶) 是比那低的。Low-molecular-weight 哼(即,二 -- 到三戒指哼) 到总数的占优势的贡献者哼内容,和小睡, AcPy,流感, PhA,和蚂蚁被发现是最丰富的。为 CC (2.248 g/m3 ) 的全部的 BaPeq 集中比为 PC (1.838 g/m3 ) 的那些高, CG (1.082 g/m3 ) ,和 DbA 作为在从 coking 过程的排出物的 BaP 是到 carcinogenic 风险的一个重要贡献者。微粒哼比对总数的相应贡献哼的占了超过 20% 全部的 BaPeq 集中,它显著地高集体集中(5%) 。微粒并且气体哼当时,应该被考虑潜在的毒性风险哼污染在 coking 期间,过程被估计。吝啬的总数 -- 哼排放因素分别地是为 CC 和 PC 的 346.132 和 93.173 g/kg。 | Ling Mu Lin Peng Junji Cao Qiusheng He Fan Li Jianqiang Zhang Xiaofeng Liu Huiling Bai | 2013 | Particuology2013，11，1： | 17 |
| 8 | Enhancing both selectivity and coking-resistance of a single-atom Pd1/C3N4 catalyst for acetylene hydrogenation显示文摘选择加氢是在化学升级的一个重要工业催化过程,在因为他们的高加氢活动,基于 Pd 的催化剂广泛地被使用的地方。然而,因为重焦炭形成,差的选择和短催化剂一生是主要担心。在这个工作,原子地驱散 Pd 原子成功地在 graphitic 碳氮化物上被综合(g-C 3 用原子层免职的 N 4) 。没有 Pd nanoparticle (NP ) ,改正错误的高角度的环形的黑暗地的扫描传播电子显微镜学(HAADF 茎) 证实了孤立的 Pd 原子的主导的存在形成。在在过量乙烯的乙炔的选择加氢期间, g-C 3 N 4-supported Pd NP 催化剂比常规 Pd/Al 2 O 3 和 Pd/SiO 2 催化剂。在原处, X 光检查光致核裂变光谱学表明可观的费用从 Pd NP 转到 g-C 3 N 4 多半在催化表演改进起一个重要作用。更给人深刻印象地,单个原子的 Pd 1/C3 N 4 催化剂展出了两种更高的乙烯选择和更高的 coking 抵抗。我们的工作证明单个原子的 Pd 催化剂是在加氢反应改进选择和焦炭抵抗的一个有希望的候选人。 | Xiaohui Huang Yujia Xia Yuanjie Cao Xusheng Zheng Haibin Pan Junfa Zhu Chao Ma Hengwei Wang Junjie Li Rui You Shiqiang Wei Weixin Huang Junling Lu | 2017 | Nano Research2017，10，4： | 16 |
| 9 | Elemental compositions of PM_(2.5) and TSP in Lijiang,southeastern edge of Tibetan Plateau during pre-monsoon period显示文摘推迟的微粒(TSP ) 取样的 PM2.5 和总数在丽江被收集,东南的西藏的高原,中国。十六个元素(艾尔, Si, S, K, Ca, Cr, Mn, Ti, Fe, Ni, Zn,同样 Br, Sb, Pb 和 Cu ) 被分析在季风前时期期间调查他们的元素的作文。结果证明 Ca 是在 PM2.5 和 TSP 样品的最丰富的元素。Si, Ti, Ca, Fe, K 和 Mn 的丰富因素(EF ) 都为 PM2.5 和 TSP 低于 10,并且这些元素也有更低的 PM2.5/TSP 比率(0.320.34 ) ,建议他们主要从外壳的来源被导出。元素 Cu, Zn, S, Br 和 Sb 在 PM2.5 和 TSP 样品显示出强壮的丰富,与他们从 0.66 ~ 0.97 的 PM2.5/TSP 比率,显示他们在好部分被充实并且由人为的来源影响了。在背轨道的 500 hPa 和计算的风地的分析显示艾尔, Si , Ca , Ti , Cr , Mn 和 Fe 能被运输在灰尘暴风雨季节,和那 S 期间从西北的中国影响, K , Ni , Br 和 Pb 从南亚在西的运输期间到达了高集中。与原则部件分析和关联分析结合了, PM2.5 样品的元素主要来自外壳的来源,生物资源燃烧排出物和地区性的交通相关的来源。 | Ningning Zhang Junji Cao Hongmei Xu Chongshu Zhu | 2013 | Particuology2013，11，1： | 14 |
| 10 | PM_(2.5) and PM_(10-2.5) chemical composition and source apportionment near a Hong Kong roadway显示文摘Twenty-four-hour PM_(2.5) and PM_(10) samples were collected simultaneously at a highly trafficked roadside site in Hong Kong every sixth day from October 2004 to September 2005.The mass concentrations of PM_(2.5),PM_(10-2.5)(defined as PM_(10)- PM_(2.5)),organic carbon(OC),elemental carbon(EC),water-soluble ions,and up to 25 elements were determined.Investigation of the chemical compositions and potential sources revealed distinct differences between PM_(2.5) and PM_(10-2.5).The annual average mass concentrations were 55.5±25.5 and 25.9±15.7 ug/m^3 for PM_(2.5) and PM_(10-2.5),respectively.EC,OM(OM =OC×1.4),and ammonium sulfate comprised over ~82% of PM_(2.5),accounting for^29%,~27%,and ~25%,respectively,of the PM_(2.5) mass.Low OC/EC ratios(less than 1) for PM_(2.5) suggested that fresh diesel-engine exhaust was a major contributor.Seven sources were resolved for PM_(2.5) by positive matrix factorization(PMF) model,including vehicle emissions(~29%),secondary inorganic aerosols(~27%),waste incinerator/biomass burning(~23%),residual oil combustion(~10%),marine aerosols(~6%),industrial exhaust(~4%),and resuspended road dust(~1%).EC and OM comprised only ~19%of PM_(10-2.5).The average OC/EC ratio of PM_(10-2.5) was 7.8±14.2,suggesting that sources other than vehicular exhaust were important contributors.The sources for PM_(10-2.5) determined by the PMF model included ~20%traffic-generated resuspension(e.g.,tire dust/brake linear/petrol evaporation),~17% locally resuspended road dust,~17% marine aerosols,~12% secondary aerosols/field burning,and ~11%vehicle emissions. | Yan Cheng Shuncheng Lee Zhaolin Gu Kinfai Ho Yunwei Zhang Yu Huang Judith C.Chow John G.Watson Junji Cao Renjian Zhang | 2015 | Particuology2015，13，1： | 14 |
| 11 | Resting-state functional connectivity abnormalities in first-onset unmedicated depression显示文摘Depression is closely linked to the morphology and functional abnormalities of multiple brain regions; however, its topological structure throughout the whole brain remains unclear. We collected resting-state functional MRI data from 36 first-onset unmedicated depression patients and 27 healthy controls. The resting-state functional connectivity was constructed using the Automated Anatomical Labeling template with a partial correlation method. The metrics calculation and statistical analysis were performed using complex network theory. The results showed that both depressive patients and healthy controls presented typical small-world attributes. Compared with healthy controls, characteristic path length was significantly shorter in depressive patients, suggesting development toward randomization. Patients with depression showed apparently abnormal node attributes at key areas in cortical-striatal-pallidal-thalamic circuits. In addition, right hippocampus and right thalamus were closely linked with the severity of depression. We selected 270 local attributes as the classification features and their P values were regarded as criteria for statistically significant differences. An artificial neural network algorithm was applied for classification research. The results showed that brain network metrics could be used as an effective feature in machine learning research, which brings about a reasonable application prospect for brain network metrics. The present study also highlighted a significant positive correlation between the importance of the attributes and the intergroup differences; that is, the more significant the differences in node attributes, the stronger their contribution to the classification. Experimental findings indicate that statistical significance is an effective quantitative indicator of the selection of brain network metrics and can assist the clinical diagnosis of depression. | Hao Guo Chen Cheng Xiaohua Cao Jie Xiang Junjie Chen Kerang Zhang | 2014 | Neural Regeneration Research2014，9，2： | 11 |
| 12 | DISTRIBUTION OF CARBONACEOUS AEROSOL DURING SPRING 2005 OVER THE HORQIN SANDLAND IN NORTHEASTERN CHINA显示文摘The objective of this study was to characterize the elemental carbon and organic carbon (EC and OC, respectively) content of aerosol particles (PM2.5) collected at Tongliao, a site in the Horqin Sandland of northeastern China. During spring 2005, the PM2.5 mass concentration was 126±71 μg?m-3, with higher dust concentrations during five dust storms than on non-dusty days (255±77 vs. 106±44 μg?m-3). The average OC and EC concentrations in PM2.5 de-termined by a thermal/optical reflectance method were 15.7±7.3 μg?m-3 and 3.3±1.7 μg?m-3, respectively, and carbona-ceous aerosol accounted for 9.9% of the PM2.5 mass during dust storms compared to 21.7% on normal days. The aver-age ratios of OC to EC during dust storms were similar to those on non-dusty days, and the correlation coefficient be-tween OC and EC was high, 0.86. The high OC/EC ratios, the distributions of eight carbon fractions, and the strong rela-tionship between K with OC and EC indicate that rural biomass burning was the dominant contributor to the regional carbonaceous aerosol. | Xuxiang Li Zhenxing Shen Junji Cao Suixin Liu Chongshu Zhu Ting Zhang | 2006 | China Particuology2006，4，6： | 10 |
| 13 | Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals显示文摘尽管 myocyte 房间移植研究为心肌的梗塞建议了一个有希望的治疗学的潜力,到为心肌的修理的临床的治疗的发展的一个主要障碍是与为移植获得相对同类的室的 myocytes 联系的困难。人的胚胎的干细胞(hESCs ) 是 cardiomyocytes 的有希望的来源。这里,我们报导发信号的 retinoid 在 hESCs 的心脏的区别期间调整 atrial 对室的 myocytes 的命运说明。我们发现少量和 pan-retinoic 酸受体对手 BMS-189453 (RAi ) 显著地增加了 hESCs 的心脏的区别效率。为了调查 retinoid,工作,我们把对待 Noggin+RAi 的文化与对待 Noggin+RA 的文化作比较。我们的结果证明室特定的基因 IRX-4 的表示层次极端地在对待 Noggin+RAi 的文化被提高。MLC-2V,另一个室特定的标记,在对待 Noggin+RAi 的文化,然而并非在对待 Noggin+RA 的文化的 cardiomyocytes 在 cardiomyocytes 的多数被表示。流动 cytometry 分析和 electrophysiological 研究与 64.7 | Qiangzhe Zhang Junjie Jiang Pengcheng Han Qi Yuan Jing Zhang Xiaoqian Zhang Yanyan Xu Henghua Cao Qingzhang Meng Li Chen Tian Tian Xin Wang Pu Li Jurgen Hescheler Guangju Ji Yue Ma | 2011 | Cell Research2011，21，4： | 10 |
| 14 | Quantifying the effects of short-term heat stress at booting stage on nonstructural carbohydrates remobilization in rice显示文摘Extreme heat stress events are becoming more frequent under anticipated climate change,which can have devastating impacts on rice growth and yield.To quantify the effects of short-term heat stress at booting stage on nonstructural carbohydrates(NSC)remobilization in rice,two varieties(Nanjing 41 and Wuyunjing 24)were subjected to 32/22/27°C(maximum/minimum/mean),36/26/31°C,40/30/35°C,and 44/34/39°C for 2,4 and 6 days in phytotrons at booting stage during 2014 and 2015.Yield and yield components,dry matter partitioning index(DMPI),NSC accumulation and translocation were measured and calculated.The results showed that the increase of high-temperature level and duration significantly reduced grain yield by suppressing spikelet number per panicle,seed-setting rate,and grain weight.Heat stress at booting decreased DMPI in panicles,increased DMPI in stems,but had no significant effect on photosynthetic rate.Stem NSC concentration increased whereas panicles NSC concentration,stem NSC translocation efficiency,and contribution of stem NSC to grain yield decreased.Severe heat stress even transformed the stem into a carbohydrate sink during grain filling.The heat-tolerant Wuyunjing 24 showed a higher NSC transport capacity under heat stress than the heat-sensitive Nanjing 41.Heat degree-days(HDD),which combines the effects of the intensity and duration of heat stress,used for quantifying the impacts of heat stress indicates the threshold HDD for the termination of NSC translocation is 9.82°C day.Grain yield was negatively correlated with stem NSC concentration and accumulation at maturity,and yield reduction was tightly related to NSC translocation reduction.The results suggest that heat stress at booting inhibits NSC translocation due to sink size reduction.Therefore,genotypes with higher NSC transport capacity under heat stress could be beneficial for rice yield formation. | Fengxian Zhen Junjie Zhou Aqib Mahmood Wei Wang Xini Chang Bing Liu Leilei Liu Weixing Cao Yan Zhu Liang Tang | 2020 | The Crop Journal2020，8，2： | 9 |
| 15 | Variability of SO_2 in an intensive fog in North China Plain:Evidence of high solubility of SO_2显示文摘一个地实验在在 11 月 5 日和 2009 年 11 月 8 日之间的一个集中的雾事件被进行,在在诺思中国平原(NCP ) 的一个重重地弄脏 SO2 的区域,到措施 SO2 和其它空气污染物质,雾微滴的液体水内容(LWC ) ,和另外的基本气象学的参数。在雾时期期间, SO2 的集中在雾微滴与 LWC 有关仔细显示出大可变性,它是。, SO2 的平均集中在雾时期期间在非雾时期期间是大约 25 ppbv,它很快归结为大约 47 ppbv。SO2 的如此的大减小建议由于 SO2 的高溶解度, SO2 (大约 70%80%) 的一个多数在雾微滴在水里从气体回复了到水的阶段。然而,到水的阶段变换的计算气体被仅仅使用亨利 SO2 的法律常数大部分低估,因此在雾微滴建议 SO2 的那水的反应可能在提高 SO2 的溶解度起某重要作用。简化现象,一个有效溶解度系数在这研究被建议。SO2 测量的这可变性在 NCP 在雾微滴,为在云的酸味的更好的理解的因此提供的重要含意,猛冲,和雾在广泛的雾事件期间提供 SO2 的氧化的直接证据,现在在中国的一个中央环境焦点由于它的快速的经济发展。 | Qiang Zhang Xuexi Tie Weili Lin Junji Cao Jiannong Quan Liang Ran Wanyun Xu | 2013 | Particuology2013，11，1： | 8 |
| 16 | Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients显示文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020). | Jiangping He Shuijiang Cai Huijian Feng Baomei Cai Lihui Lin Yuanbang Mai Yinqiang Fan Airu Zhu Huang Huang Junjie Shi Dingxin Li' Yuanjie Wei Yueping Li Yingying Zhao’ Yuejun Pan He Liu Xiaoneng Mo Xi He Shangtao Cao FengYu Hu Jincun Zhao Jie Wang Nanshan Zhong Xinwen Chen Xilong Deng Jiekai Chen | 2020 | Protein & Cell2020，11，9： | 7 |
| 17 | PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis显示文摘Prostaglandin E2(PGE2), a major cyclooxygenase-2(COX-2) product, is highly secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis(OA) patients. However, NSAIDs, including COX-2 inhibitors, have severe side effects during OA treatment. Therefore, the identification of novel drug targets of PGE2 signaling in OA progression is urgently needed. Osteoclasts play a critical role in subchondral bone homeostasis and OA-related pain. However, the mechanisms by which PGE2 regulates osteoclast function and subsequently subchondral bone homeostasis are largely unknown. Here, we show that PGE2 acts via EP4 receptors on osteoclasts during the progression of OA and OA-related pain. Our data show that while PGE2 mediates migration and osteoclastogenesis via its EP2 and EP4 receptors, tissue-specific knockout of only the EP4 receptor in osteoclasts(EP4 Lys M) reduced disease progression and osteophyte formation in a murine model of OA. Furthermore, OA-related pain was alleviated in the EP4 Lys M mice, with reduced Netrin-1 secretion and CGRP-positive sensory innervation of the subchondral bone. The expression of plateletderived growth factor-BB(PDGF-BB) was also lower in the EP4 Lys Mmice, which resulted in reduced type H blood vessel formation in subchondral bone. Importantly, we identified a novel potent EP4 antagonist, HL-43, which showed in vitro and in vivo effects consistent with those observed in the EP4 Lys Mmice. Finally, we showed that the Gαs/PI3 K/AKT/MAPK signaling pathway is downstream of EP4 activation via PGE2 in osteoclasts. Together, our data demonstrate that PGE2/EP4 signaling in osteoclasts mediates angiogenesis and sensory neuron innervation in subchondral bone, promoting OA progression and pain, and that inhibition of EP4 with HL-43 has therapeutic potential in OA. | Wenhao Jiang Yunyun Jin Shiwei Zhang Yi Ding Konglin Huo Junjie Yang Lei Zhao Baoning Nian Tao PZhong Weiqiang Lu Hankun Zhang Xu Cao Karan Mehul Shah Ning Wang Mingyao Liu Jian Luo | 2022 | Bone Research2022，10，2： | 7 |
| 18 | A novel xeno-free and feeder-cell-free system for human pluripotent stem cell culture显示文摘While human induced pluripotent stem cells(hiPSCs)have promising applications in regenerative medicine,most of the hiPSC lines available today are not suitable for clinical applications due to contamination with nonhuman materials,such as sialic acid,and potential pathogens from animal-product-containing cell culture systems.Although several xeno-free cell culture systems have been established recently,their use of human fibroblasts as feeders reduces the clinical potential of hiPSCs due to batch-to-batch variation in the feeders and time-consuming preparation processes.In this study,we have developed a xeno-free and feeder-cell-free human embryonic stem cell(hESC)/hiPSC culture system using human plasma and human placenta extracts.The system maintains the self-renewing capacity and pluripotency of hESCs for more than 40 passages.Human iPSCs were also derived from human dermal fibroblasts using this culture system by overexpressing three transcription factors—Oct4,Sox2 and Nanog.The culture system developed here is inexpensive and suitable for large scale production. | Qihui Wang Xiaoning Mou Henghua Cao Qingzhang Meng Yanni Ma Pengcheng Han Junjie Jiang Hao Zhang Yue Ma | 2012 | Protein & Cell2012，3，1： | 6 |
| 19 | Fighting the enemy: How rice survives the blast pathogen's attack显示文摘Global food security is threatened by rice blast disease caused by the filamentous fungus Magnaporthe oryzae.An understanding of rice resistance mechanisms is fundamental to developing strategies for disease control.In this review,we summarize recent advances in pathogen-associated molecular pattern-triggered immunity,effector-triggered immunity,defense regulator-mediated immunity,and effects of nutrient elements on rice blast resistance.We outline strategies used for breeding rice cultivars with improved disease resistance.We also present the major research challenges for rice blast disease resistance and propose approaches for future investigation. | Junjie Yin Lijuan Zou Xiaobo Zhu Yuyan Cao Min He Xuewei Chen | 2021 | The Crop Journal2021，9，3： | 6 |
| 20 | Investigation on the Morphological Characteristics of Dendrobium officinale Plantlets Propagated from Different Explants显示文摘[Objective]This study aimed to investigate the differences in morphological characteristics of Dendrobium officinale plantlets propagated from different explants.[Method]Randomly 1 000 D. officinale plantlets propagated via different regeneration pathways were selected for morphological investigation and classification.[Result] D. officinale plantlets propagated from stem segment explants exhibited highly consistent morphological characteristics,while those propagated from seed explants exhibited a variety of morphological characteristics.[Conclusion] Therefore,using seed explants for regeneration can effectively broaden the germplasms resources of D. officinale. | Jiaxian LIANG Junjie MO Hancai CAO Qianting TAN | 2014 | Agricultural Biotechnology2014，3，5： | 5 |
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