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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 3 | 巨峰和无核早红葡萄在越南谅山试种观察显示文摘[目的]观察巨峰、无核早红葡萄在越南谅山省的引种表现,为其在越南推广种植提供参考依据.[方法]2009年春从中国南宁引入巨峰、无核早红两个鲜食葡萄品种在越南谅山省试种,调查其枝蔓生长量、物候期、果实性状、产量等相关指标.[结果]至第1年抚育冬季,巨峰葡萄枝蔓总长234.5 cm,上架茎粗0.84 cm;无核早红葡萄枝蔓总长294.1 cm,上架茎粗0.86 cm.在物候期方面,巨峰葡萄从萌芽至果实成熟需141~151 d,表现中熟;无核早红从萌芽至果实成熟需142~151 d,未表现其应有的早熟特性.在果实性状方面,巨峰葡萄2010~2012年3年平均单果重8.9 g,种子数1.04粒,可溶性固形物(TSS)含量17.5%;无核早红葡萄2010~2012年3年平均单果重6.8 g,TSS含量13.9%.在产量方面,巨峰葡萄2010~2012年产量分别为13.69、17.50和16.24 t/ha;无核早红葡萄2010~2012年产量分别为10.81、16.02和20.92t/ha.[结论]巨峰葡萄在越南谅山省种植表现丰产稳产优质,具有较好的适栽性,可大面积推广种植;无核早红葡萄表现丰产稳产,但表现低糖低酸,极易裂果,着色困难,不宜在越南大面积发展. | 黄江流 PHAM Thi Thang 罗瑞鸿 NGUYN Thi Hà 吕荣华 LUONG Dǎng Ning CHU Vǎn DUòng NGUYN Manh Tòng 彭宏祥 Ly Ming Nguyet LU'O'NG i Thuy CHU Xun Tien VI Vǎn Dúc NGUYN Duy Dng Ly Dúc Khiêm 熊俏 | 2014 | 南方农业学报2014，45，7： | 5 |
| 4 | Caffeic acid phenethyl ester blocks free radical generation and 6-hydroxydopamine-induced neurotoxicity显示文摘 | Ma Z Wei X Fontanilla C Noelker C Dodel R Hampel H Du Y | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 5 | 计算机辅助截骨术指导和预弯钛板改善面部不对称矫正手术的规划显示文摘本研究评估了计算机辅助截骨术和预弯钛板治疗面部不对称患者的手术效果和准确性。纳入13例面部不对称进行双颌手术的患者。如果需要,在术前三维模型上进行Le Fort I型截骨术,下颌支矢状劈开截骨术和颏成形术的虚拟模拟。 | Ji H Du W Xu C 赵泽亮 | 2019 | 中国口腔颌面外科杂志2019，17，2： | 3 |
| 6 | The possible role of hyyrogen sulfide on the pathogenesis of spontaneous hypertension in rats 显示文摘 | YAN H DU J TANG C | 2004 | Bioc hem Biophys Res Commun2004，313，1： | 2 |
| 7 | Serum amyloid P component and C-reactive protein mediate phagocytosis through murine FcγRs显示文摘 | Mold C Gresham H D Du Clos T W | 2001 | J Immunol2001，166，： | 2 |
| 8 | Towards the Development of Novel Antibiotics: Synthesis and Evaluation of a Mechanism-based Inhibitor of Kdo8P Synthase 显示文摘 | DU S C FAIGER H BELAKHOV V | 1999 | Bioorgan Med Chem1999，7，12： | 1 |
| 9 | Study in IC Chip Failure during Pick-up Process by Using Experimental and Finite Element Methods 显示文摘 | T H Cheng C C Du C H Tseng | 2006 | Journal of Materials Processing Technology2006，172，： | 1 |
| 10 | Free vibration analysis of curvilinear quadrilateral plates by the differential quadrature method显示文摘 | Shu C Chen W Du H | 2000 | J Comput Phys2000，163，2： | 1 |
| 11 | Flavonoid composition and antioxidant activity of tree peony (Paeonia section moutan) yellow flowers 显示文摘 | LI C H DU H WANG L S | 2009 | J Agr Food Chem2009，57，18： | 1 |
| 12 | Rangeland degradation in a semi-arid South Mrica--II : influence on soil quality 显示文摘 | Snyman H Du Preez C | 2005 | Journal of Arid Environments2005，60，3： | 1 |
| 13 | Achieving ultratine grain size in Mg-A1-Zn alloy by friction stir processing显示文摘 | CHANG C I DU X H HUANG J C | 2007 | Scripta Materialia2007，57，3： | 1 |
| 14 | Crosssectional survey of human papillomavirus subtype distribution and cervical intraepithelial neoplasia inShenzhen显示文摘 | Liang LY DU H Wang C | 2013 | Beijing Daxue Xuebao2013，45，1： | 1 |
| 15 | Cloning,expression inEscherichia coli,and purification of soluble recombi-nant duck interleukin-2显示文摘 | DU C H HAN L XIE Z H | 2012 | World J Microbiol Bio-technol2012，28，： | 1 |
| 16 | Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators显示文摘 | Du X Zhang H Lopes C | 2004 | J Biol Chem2004，279，37： | 1 |
| 17 | Numerical simulation of an advanced energy storage system using H2O-LiBr as working fluid(Ⅱ):System simulation and analysis显示文摘 | Xu S M Xu C H Zhang L Liang J Du R | | 0，，02： | 1 |
| 18 | Co-overexpression FIT with AtbHLH38 or AtbHLH39 in Ambidopsis-enhanced cadmium tolerance via increased cadmium sequestration in roots and improved iron homeostasis of shoots显示文摘 | Wu H L Chen C Du J | 2012 | Plant Physiology2012，158，2： | 1 |
| 19 | Function projective synchronization of different chaotic systems with uncertain parameters显示文摘 | DU H Y ZENG Q S WANG C H | 2008 | Physics Letters:A2008，372，33： | 1 |
| 20 | Ultratiiin SnO2 nanosheets:oriented attachment mechanism,nonstoichiometric defects,and enhanced lithium-ion battery performances显示文摘 | WANG C DU G H STAHL K | 2012 | Journal of Chemical Physics C2012，116，： | 1 |
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