| 1 | Lycium barbarum polysaccharide ameliorates radiation-induced brain injury by regulating gut microbiota显示文摘Objective: To determine the extent to which Lycium barbarum polysaccharide(LBP) improves60Co γ-ray radiation-induced brain injury(RIBI) by regulating the gut microbiota.Methods: The RIBI model of mice was established with the appropriate dose of60Co γ-ray to identify the changes in the body weight, behaviors, gut microbiota, and inflammatory reactions of mice. Mice were randomly divided into healthy, RIBI model, and LBP groups. The related inflammatory cytokines were determined using an enzyme linked immunosorbent assay kit. Then, 16S rRNA sequencings of feces were carried out to evaluate the differences in intestinal flora.Results: Compared with the spontaneous activity and exploratory spirit of the healthy group, those traits in the RIBI model mice in the open field significantly decreased, the freezing time in the elevated plus maze(EPM) significantly increased, and the number of times the mice discriminated the novel object was significantly lower. Hematoxylin-eosin slides showed that the main histopathological changes of RIBI occurred in the hippocampus. In addition, the diversity and relative abundances ratio of the gut bacterial phylum, order, family, and genus in the model group varied widely. Changes in Bacteroidetes,Firmicutes, and Proteobacteria were the most obvious after head radiation exposure. In comparison, LBP could accelerate the recovery of weight loss in RIBI mice. The frequency that mice entered the center of the open field, facing the open arm in the EPM, and the number of times they discriminated the novel object were significantly increased with LBP administration. LBP could also reduce the levels of inflammatory factor caused by RIBI. LBP increased the diversity and abundance of gut microbiota in RIBI model mice. In addition, LBP increased the relative abundance of Bacteroidetes but decreased the levels of Firmicutes and Proteobacteria for irradiated mice.Conclusion: LBP can improve depression and tension by regulating the composition of gut microbiota,including lowering the relative abundance of Clostridia and Burkholderiales and raising that of Lactobacillales. Thus, LBP provides a new strategy for improving the protective effects of RIBI. | Jinglu Hu Chunqing Wang Qi Li Wencheng Jiao Xiaojuan Chen Baiping Ma Lina Du | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，1： | 1 |
| 2 | Field Investigation of the M_S6.8 Wuqia,Xinjiang Earthquake on October 5,2008显示文摘A M S 6.8 earthquake occurred on October 5,2008 in the Wuqia region in Xinjiang.The macroseismic epicenter is situated in the Nula village of the Kyrghyz Republic,7km southwest of the Wuqia Yierkeshitan Port in Xinjiang.The epicenter intensity is Ⅷ degrees (outside borders).The areas of intensity Ⅶ and Ⅵ are 7354km 2 and 1031km 2,respectively.This seismic event is related with movement of the NE-trending Kzikeaerkate fault belt.Buildings in the earthquake-stricken area were damaged or affected to a certain extent by this earthquake,accompanied with some phenomena of geological disaster. | Chen Jianbo Tan Ming Kou Dabing Gao Guoying Hu Weihua Du Chunqing Hou Jiansheng Li Zhiqiang Zhao Baozong Zhang Tiangang Ning Baokun | 2010 | Earthquake Research in China2010，24，4： | 0 |
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