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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | Trend of declining stroke mortality in China:reasons and analysis显示文摘Introduction There is a downward trend of stroke-related mortality in the USA.By reviewing all published articles on stroke mortality in China,we analysed its trend and possible factors that have influenced the trend.Methods Both English and Chinese literatures were searched on the mortality of stroke or cerebrovascular diseases in China.Potential papers related to this topic were identified from PubMed,Medline,Embase,Cochrane Library,Wanfang Database,SINOMED and China National Knowledge Infrastructure databases.Results Comparing the results from the most recent population-based epidemiological survey and databank from the national Center for Disease Control and Prevention,the age-adjusted stroke mortality rate has shown a downward trend among both urban and rural population in the past 30 years in China.Comparing with 30 years ago,the rate of stroke mortality has decreased by more than 31%in urban/suburban population and 11%in rural population.In men,the age-adjusted stroke mortality rate decreased by 18.9%and in women by 24.9%between 1994 and 2013.Factors that may have contributed to the trend of decreased stroke mortality rate include(1)improved healthcare coverage and healthcare environment;(2)improved treatment options and medical technology;(3)support by government to educate the public on stroke and stroke prevention;and(4)improved public knowledge on stroke.Conclusions The age-adjusted stroke mortality rate in China has shown a downward trend among both urban and rural population in the past 30 years.The major influencing factors that helped in reducing stroke mortality in China included improved healthcare coverage,healthcare environment,the updated treatment options and modern medical technology. | Wenzhi Wang David Wang Hongmei Liu Haixin Sun Bin Jiang Xiaojuan Ru Dongling Sun Zhenghong Chen Yongjun Wang | 2017 | Stroke & Vascular Neurology2017，2，3： | 52 |
| 3 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 4 | CRISPR-Cas9-mediated multiplex gene editing in CAR-T cells显示文摘 | Xiaojuan Liu Yongping Zhang Chen Cheng Albert W Cheng Xingying Zhang Na Li Changqing Xia Xiaofei Wei Xiang Liu Haoyi Wang | 2017 | Cell Research2017，27，1： | 40 |
| 5 | Ultralong-life and high-rate web-like Li4Ti5O12 anode for high-performance flexible lithium-ion batteries显示文摘 | Xianfu Wang Bin Liu Xiaojuan Hou Qiufan Wang Wenwu Li Di Chen Guozhen Shen | 2014 | Nano Research2014，7，7： | 16 |
| 6 | Comparison and significance of specific and non-specific cellular immunity in patients with chronic hepatitis B caused by infection with genotypes B or C of hepatitis B virus显示文摘The present study was designed to investigate possible relationships between the genotypes of hepatitis B virus(HBV) and the HBV-specific cytotoxic T lymphocyte(CTL) responses.HBV genotypes,HBV specific CTL HBV DNA and other markers of HBV infection were determined in 138 patients with chronic hepatitis B.The results showed that the patients infected with genotype C(n=62) had a significantly lower HBV-specific CTL response than those who were infected with HBV genotype B(P<0.01).HBV DNA titer was higher in patients infected with HBV genotype C than in those infected with HBV geno-type B(P<0.01).Both alanine aminotransferase(ALT) and total bilirubin(TBIL) were higher in HBV genotype C infected patients than in those infected with genotype B(P<0.01 and <0.05,respectively).These results suggest that compared with CHB patients infected with HBV genotype B,the higher HBV DNA level and more severe liver damages in the patients infected with genotype C of HBV may be associated with genotype C of the virus. | GU XiBing,YANG XiaoJuan,WANG Dong,HUA Zhong,WU HangYuan,CHEN HaoKun,XU YueQin & LU ZhongHua Wuxi Hospital for Infectious Diseases,Wuxi 214005,China | 2009 | Science China(Life Sciences)2009，52，8： | 16 |
| 7 | SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3- TBK1 complex显示文摘SARS coronavirus (SARS-CoV ) 开发躲避干扰素(IFN ) 的抗病毒的活动的对抗机制。以前的研究建议那 SARS-CoV 象 papain 一样朊酶(PLpro ) 禁止 IRF3 小径的激活,它将通常得到柔韧的 IFN 回答,但是机制由 SARS PLpro 使用了禁止 IRF3 小径的激活充分不被知道。在这研究,我们揭开了可以解释 SARS PLpro 怎么高效地禁止 IRF3 小径的激活的新奇机制。我们发现从 SARS-CoV 的抛锚膜的 PLpro 领域(PLpro-TM ) 的那表情禁止类型的 STING/TBK1/IKK-mediated 激活我 IFN 并且破坏 IRF3 的 phosphorylation 和 dimerization,它被圈套和 TBK1 激活。同时,我们证明 PLpro-TM 身体上与 TRAF3, TBK1, IKK,圈套,和 IRF3 交往,为 IFN 的激活装配 STING-TRAF3-TBK1 建筑群的关键部件表示。然而,在在 STING-TRAF3-TBK1 建筑群的部件之间的相互作用被 PLpro-TM 破坏。而且, SARS PLpro-TM 在 STING-TRAF3-TBK1 建筑群减少 RIG-I,圈套, TRAF3, TBK1,和 IRF3 的 ubiquitinated 形式的层次。这些结果一起指向 PLpro 否定地由和 STING-TRAF3-TBK1 建筑群的相互作用通过调整 IRF3 激活的 SARS-CoV 使用的新机制,产出一项 SARS-CoV 反措施对招待天生的免疫。 | Xiaojuan Chen Xingxing Yang Yang Zheng Yudong Yang Yaling Xing Zhongbin Chen | 2014 | Protein & Cell2014，5，5： | 15 |
| 8 | Coronavirus membrane-associated papain-like proteases induce autophagy through interacting with Beclinl to negatively regulate antiviral innate immunity显示文摘 | Xiaojuan Chen Kai Wang Yaling Xing Jian Tu Xingxing Yang Qian Zhao Kui Li Zhongbin Chen | 2014 | Protein & Cell2014，5，12： | 14 |
| 9 | Spatial-temporal Characteristics of Land Subsidence Corresponding to Dynamic Groundwater Funnel in Beijing Municipality,China显示文摘Due to long-term over-exploitation of groundwater in Beijing Municipality,regional groundwater funnels have formed and land subsidence has been induced.By combining a groundwater monitoring network,GPS monitor-ing network data,radar satellite SAR data,GIS and other new technologies,a coupled process model based on the dy-namic variation of groundwater and the deformation response of land subsidence has been established.The dynamic variation of groundwater funnels and the land subsidence response process were analyzed systematically in Beijing.Study results indicate that current groundwater funnel areas are distributed mainly in the southwest of Shunyi District,the northeast of Chaoyang District and the northwest of Tongzhou District,with an average decline rate of groundwa-ter level of 2.66 m/yr and a maximum of 3.82 m/yr in the center of the funnels.Seasonal and interannual differences exist in the response model of land subsidence to groundwater funnels with uneven spatial and temporal distribution,where the maximum land subsidence rate was about-41.08 mm/yr and the area with a subsidence rate greater than 30 mm/yr was about 1637.29 km2.Although a consistency was revealed to exist between a groundwater funnel and the spatial distribution characteristics of the corresponding land subsidence funnel,this consistency was not perfect.The results showed that the response model of land subsidence to the dynamic variation of groundwater was more revealing when combining conventional technologies with InSAR,GIS,GPS,providing a new strategy for environmental and hydrogeological research and a scientific basis for regional land subsidence control. | CHEN Beibei GONG Huili LI Xiaojuan LEI Kunchao ZHANG Youquan LI Jiwei GU Zhaoqin DANG Yanan | 2011 | Chinese Geographical Science2011，21，6： | 13 |
| 10 | Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases显示文摘 | Xiangxiu Liang Miaomiao Ma ,Zhaoyang Zhou Jinlong Wang Xinru Yang Shaofei Rao Guozhi Bi Lin Li Xiaojuan Zhang Jijie Chai She Chen Jian-Min Zhou | 2018 | Cell Research2018，28，5： | 13 |
| 11 | Adaptive subsequence adjustment with evolutionary asymmetric path-relinking for TDRSS scheduling显示文摘Due to the limited transmission resources for data relay in the tracking and data relay satellite system(TDRSS), there are many job requirements in busy days which will be discarded in the conventional job scheduling model. Therefore, the improvement of scheduling efficiency in the TDRSS can not only help to increase the resource utilities, but also to reduce the scheduling failure ratio.A model of nonhomogeneous parallel machines scheduling problems with time window(NPM-TW) is firstly built up for the TDRSS,considering the distinct features of the variable preparation time and the nonhomogeneous transmission rates for different types of antennas on each tracking and data relay satellite(TDRS). Then,an adaptive subsequence adjustment(ASA) framework with evolutionary asymmetric path-relinking(Ev APR) is proposed to solve this problem, in which an asymmetric progressive crossover operation is involved to overcome the local optima by the conventional job inserting methods. The numerical results show that, compared with the classical greedy randomized adaptive search procedure(GRASP) algorithm, the scheduling failure ratio of jobs can be reduced over 11% on average by the proposed ASA with EvAPR. | Peng Lin Linling Kuang Xiang Chen Jian Yan Jianhua Lu Xiaojuan Wang | 2014 | Journal of Systems Engineering and Electronics2014，25，5： | 12 |
| 12 | Advanced rechargeable lithium-ion batteries based on bendable ZnCo2O4-urchins-on-carbon-fibers electrodes显示文摘ZnCo2O4-urchins-on-carbon-fibers 矩阵的一个新奇的班被设计了,描绘,并且过去常制作高效的精力存储设备。我们获得了 1180 妈数慲畴敲 ?L 癯 ? ㈱? 的一个可逆的锂存储能力 ?? 牣慥楳杮倠 ? 挠湯整瑮 ?? 桳牯 ? 整浲 ??? 琠敨浲污琠敲瑡敭瑮 ? 瑡 ??? 鲖 ? 栀氠睯牥愠摮甠灰牥焠慵瑮汩獥映牯搠楡祬洠湩浩浵琠浥数爔?爔 吗?? | Bin Liu Xianfu Wang Boyang Liu Qiufan Wang Dongsheng Tan Weifeng Song Xiaojuan Hou Di Chen Guozhen Shen | 2013 | Nano Research2013，6，7： | 10 |
| 13 | δ^(13)C difference between plants and soil organic matter along the eastern slope of Mount Gongga显示文摘Carbon isotope ratios (δ 13C) of plants, litter and soil organic matter (0–5 cm, 5–10 cm and 10–20 cm) on the eastern slope of Mount Gongga were measured. The results show that δ 13C values of plants, litter and soil organic matter all decrease first and then increase with altitude, i.e. δ 13C values gradually decrease from 1200 to 2100 m a.s.l., and increase from 2100 to 4500 m a.s.l. The δ 13C altitudinal variations are related to the distribution of C3 and C4 plants on the eastern slope of Mount Gongga, because C4 plants are observed to grow only below 2100 m, while C3 plants occur at all altitudes. There are significantly positive correlations among δ 13C of vegetation, δ 13C of litter and δ 13C of soil organic matter, and litter, 0–5 cm, 5–10 cm and 10–20 cm soil organic matter are 0.56‰, 2.87‰, 3.04‰ and 3.49‰ greater in δ 13C than vegetation, respectively. Considering the influences of rising concentration of atmospheric CO2 and decreasing δ 13C of atmospheric CO2 since the industry revolution on δ 13C of plants, 1.57‰ is proposed to be the smallest correction value for reconstruction of paleovegetation using δ 13C of soil organic matter. | CHEN PengNa WANG GuoAn HAN JiaMao LIU XiaoJuan LIU Min | 2010 | Chinese Science Bulletin2010，55，1： | 9 |
| 14 | CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells显示文摘 | Yongping Zhang Xingying Zhang Chen Cheng Wei Mu Xiaojuan Liu Na Li Xiaofei Wei Xiang Liu Changqing Xia Haoyi Wang | 2017 | Frontiers of Medicine2017，11，4： | 9 |
| 15 | RNA-binding protein LIN28B inhibits apoptosis through regulation of the AKT2/FOXO3A/BIM axis in ovarian cancer cells显示文摘LIN28B is an evolutionarily conserved RNA-binding protein that regulates mRNA translation and miRNA let-7 maturation in embryonic stem cells and developing tissues.Increasing evidence demonstrates that LIN28B is activated in cancer and serves as a critical oncogene.However,the underlying molecular mechanisms of LIN28B function in tumorigenesis are still largely unknown.Here we report that LIN28B was expressed in over half of the patients with epithelial ovarian cancer who were examined(n=584).Functional experiments demonstrated that LIN28B inhibited ovarian cancer cell apoptosis.Furthermore,we showed that the proapoptotic factor BIM played an essential role in the antiapoptotic function of LIN28B.RNA-IP microarray analysis suggested that LIN28B binds to mRNAs that are associated with the DNA damage pathway,such as AKT2,in ovarian cancer cells.By binding to AKT2 mRNA and enhancing its protein expression,LIN28B regulated FOXO3A protein phosphorylation and decreased the transcriptional level of BIM,which antagonized the antiapoptosis activity of LIN28B.Taken together,these results mechanistically linked LIN28B and the AKT2/FOXO3A/BIM axis to the apoptosis pathway.The findings may have important implications in the diagnosis and therapeutics of ovarian cancer. | Xiaojuan Lin Jianfeng Shen Dan Peng Xinhong He Congjian Xu Xiaojun Chen Janos LTanyi Kathleen Montone Yi Fan Qihong Huang Lin Zhang Xiaomin Zhong | 2018 | Signal Transduction and Targeted Therapy2018，3，1： | 8 |
| 16 | Laboratory testing and molecular analysis of the resistance of wild and cultivated soybeans to cotton bollworm, Helicoverpa armigera(Hübner)显示文摘Identifying a superior soybean variety with high defoliator resistance is important to avoid yield loss. Cotton bollworm(Helicoverpa armigera Hübner) is one of the major defoliators of soybean(Glycine max [L.] Merr.) worldwide. In this study, we evaluated the effect of H. armigera larvae on ED059, a wild soybean(Glycine soja Sieb. et Zucc.), and three cultivated soybean varieties: Tianlong 2, PI 535807, and PI 533604, in choice and no-choice assays. The percentage of ED059 leaflets consumed by H. armigera was lower than that of the three cultivated soybeans. Larvae that fed on ED059 exhibited low weight gain and high mortality rate.Waldbauer nutritional indices suggested that ED059 reduced the growth, consumption, and frass production of H. armigera larvae. Larvae that fed on ED059 showed lower efficiency of conversion of ingested and of digested food than those that fed on Tianlong 2 and PI 533604.However, they showed statistically similar consumption index and approximate digestibility compared with those fed on the three cultivated soybeans. Quantitative real-time PCR analysis revealed that 24 h after insect attack, ED059 had higher transcript levels of Kunitz trypsin inhibitor 3, Cysteine proteinase inhibitor 2, and Nerolidol synthase 1 but a lower transcript level of Pathogenesis-related protein 1 than Tianlong 2. The gene expression results were consistent with the presence of higher levels of jasmonic acid(JA) and transcript levels of the JA biosynthesis enzyme allene oxide cyclase 3 in ED059 than in Tianlong 2. Our findings indicate that ED059 is a superior soybean line with strong insect resistance that may be mediated via the JA pathway. | Xiaoyi Wang Haifeng Chen Aihua Sha Rong Zhou Zhihui Shang Xiaojuan Zhang Chanjuan Zhang Limiao Chen Qingnan Hao Zhonglu Yang Dezhen Qiu Shuilian Chen Xinan Zhou | 2015 | The Crop Journal2015，3，1： | 6 |
| 17 | Outcomes of Coaxial Micro-incision Phacoemulsification in Nanophthalmic Eyes: Report of Retrospective Case Series显示文摘Purpose: The surgical risk and complication rate after cataract surgery are extremely high in patients with nanophthalmos.This study is designed to compare the visual and refractive outcomes before and after coaxial micro-incision phacoemulsification and evaluate postoperative complications.Methods:.Fifty nine patients(89 eyes) with axial length(AL)< 21 mm diagnosed with nanophthalmos were enrolled in this retrospective study. All patients underwent coaxial micro-incision phacoemulsification and IOL implantation..The main outcome measures included anterior chamber depth(ACD),anterior chamber volume(ACV), anterior chamber angle(A CA), intraocular pressure(IOP) and best corrected visual acuity(BCVA). Wilcoxon signed rank test or Mann-Whitney test,and Chi-square test and logistic regression analysis were performed for statistical tests as appropriate.Results:.The median AL was 19.63 mm...Sixty-six eyes(74.16%) had a history of surgical intervention. Postoperative ACD, ACV and ACA were increased significantly(all P<0.001),whereas postoperative IOP was decreased significantly.(P <0.001) after surgery. Previous surgical intervention was related to a reduction in the postoperative ACD and ACA(P<0.01),and both preoperative and postoperative IOP.(P <0.001).Postoperative BCVA was improved in 94.38% of the cases.Intraoperative complications mainly included iridoschisis(6eyes, 6.74%). Early postoperative complications included temporary corneal edema(TCE)(23 eyes, 25.84%), anterior inflammatory response(AIR)(19 eyes, 21.35%), cystoid macular edema(CME)(14 eyes, 15.73%), and uveal effusion(4 eyes, 4.49%). Late postoperative complications included CME(8 eyes, 8.99%), uveal effusion(8 eyes, 8.99%),malignant glaucoma(2 eyes, 2.25%) and posterior capsular opacification(PCO)(10 eyes, 11.24%). The majority of complications(80%) were successfully resolved by pharmacotherapy or operation. The risk of surgical complications was greater in patients with lower AL,ACD,ACV or ACA andhigher nuclear hardness or mean keratometry(Km).Conclusion: With reasonable preoperative management, prudent selection of the lens,.rigorous surgical technique and unerring cognition of potential complications, coaxial microincision phacoemulsification lens surgery can be performed in patients with nanophthalmos and yield favorable outcomes and a low incidence of complications. | Zi Ye Zhaohui Li Shouzhi He Bing Chen Xiaojuan Xing Chunyan Ren | 2015 | Eye Science2015，30，3： | 5 |
| 18 | Establishment and functional characterization of the reversibly immortalized mouse glomerular podocytes(imPODs)显示文摘Glomerular podocytes are highly specialized epithelial cells and play an essential role in establishing the selective permeability of the glomerular filtration barrier of kidney.Maintaining the viability and structural integrity of podocytes is critical to the clinical management of glomerular diseases,which requires a thorough understanding of podocyte cell biology.As mature podocytes lose proliferative capacity,a conditionally SV40 mutant tsA58-immortalized mouse podocyte line(designated as tsPC)was established from the Immortomouse over 20 years ago.However,the utility of the tsPC cells is hampered by the practical inconvenience of culturing these cells.In this study,we establish a user-friendly and reversibly-immortalized mouse podocyte line(designated as imPOD),on the basis of the tsPC cells by stably expressing the wildtype SV40 T-antigen,which is flanked with FRT sites.We show the imPOD cells exhibit long-term high proliferative activity,which can be effectively reversed by FLP recombinase.The imPOD cells express most podocyte-related markers,including WT-1,Nephrin,Tubulin and Vinculin,but not differentiation marker Synaptopodin.The imPOD cells do not form tumor-like masses in vivo.We further demonstrate that TGFb1 induces a podocyte injury-like response in the FLP-reverted imPOD cells by suppressing the expression of slit diaphragm-associated proteins P-Cadherin and ZO-1 and upregulating the expression of mesenchymal markers,a-SMA,Vimentin and Nestin,as well as fibrogenic factors CTGF and Col1a1.Collectively,our results strongly demonstrate that the newly engineered im-POD cells should be a valuable tool to study podocyte biology both under normal and under pathological conditions. | Xinyi Yu Liqun Chen Ke Wu Shujuan Yan Ruyi Zhang Chen Zhao Zongyue Zeng Yi Shu Shifeng Huang Jiayan Lei Xiaojuan Ji Chengfu Yuan Linghuan Zhang Yixiao Feng Wei Liu Bo Huang Bo Zhang Wenping Luo Xi Wang Bo Liu Rex C.Haydon Hue H.Luu Tong-Chuan He Hua Gan | 2018 | Genes & Diseases2018，5，2： | 5 |
| 19 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 20 | Shortened snRNA promoters for efficient CRISPR/Cas-based multiplex genome editing in monocot plants显示文摘Dear Editor,CRISPR(clustered regularly interspaced short palindromic repeats)/Cas genome editing is a powerful tool for introducing specific mutations in organisms including plants.The system is composed of a nuclease such as Cas9 or Cas12a and an engineered single-guide RNA(sgRNA)incorporating a target sequence(Li et al.,2019).A Cas9/sgRNA complex recognizes its target site in the genome,resulting in a mutation at that site. | Yu Hao Wubei Zong Dongchang Zeng Jingluan Han Shuifu Chen Jianian Tang Zhe Zhao Xiaojuan Li Kun Ma Xianrong Xie Qinlong Zhu Yuanling Chen Xiucai Zhao Jingxin Guo Yao-Guang Liu | 2020 | Science China(Life Sciences)2020，63，6： | 4 |
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