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您的检索式：作者名="Duan Heping"
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| 1 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 2 | Synthesis of Tetra-O-Alkylated Calix[4]arenes under Phase-Transfer Conditions显示文摘A modified PTC method of preparing tetra-O-aIkylated callx[4]arenes is described. Using PEG-400 as phase-transfer catalyst and solld sodlum hydrate as a base, full alkylatlon of calix[4]arenes has beenproceeded smoothly in toluene at 9℃. The debutylated callx[4]arene can also be fully alkylated by thismethid. | Hu Xubo Ce Yinyin Duan Heping Lu Xueran Chen Yuanyin | 1998 | Wuhan University Journal of Natural Sciences1998，3，2： | 0 |
| 3 | Risk factors associated with mortality of COVID-19 in 3125 counties of the United States显示文摘Background:The number of cumulative confirmed cases of COVID-19 in the United States has risen sharply since March 2020.A county health ranking and roadmaps program has been established to identify factors associated with disparity in mobility and mortality of COVID-19 in all counties in the United States.The risk factors associated with county-level mortality of COVID-19 with various levels of prevaIence are not well understood.Methods:Using the data obtained from the County Health Rankings and Roadmaps program,this study applied a negative binomial design to the courtty-level mortality counts of COVID-19 as of August 27,2020 in the United States.In this design,the infected counties were categorized into three levels of infections using clustering analysis based on time-var ying cumulative con firmed cases from March 1 to August 27,2020.COVID-19 patients were not analyzed in dividually but were aggregated at the county-level,where the coun ty-level deaths of COVID-19 con firmed by the local health agencies.Clustering analysis and Kruskal-Wallis tests were used in our statistical analysis. | Ting Tian Jingwen Zhang Liyuan Hu Yukang Jiang Congyuan Duan Zhongfei Li Xueqin Wang Heping Zhang | 2021 | Infectious Diseases of Poverty2021，10，1： | 0 |
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