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| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Xp11易位性肾细胞癌和免疫组化TFE3强阳性的透明细胞性肾细胞癌:形态学、免疫组化和FISH分析显示文摘TFE3是诊断Xp11易位性肾细胞癌的良好标志物。然而,TFE3在其他类型肾细胞癌中的意义尚不清楚。作者利用自动化Ventana BenchMark XT系统采用免疫组化法检测了1 818例肾细胞癌组织中TFE3的表达情况,并用TFE3分裂探针采用荧光原位杂交和RNA测序技术检测了TFE3强阳性病例。27例免疫组化TFE3强阳性的肾细胞癌中,20例诊断为Xp11易位性肾细胞癌,7例诊断为透明细胞性肾细胞癌。作者进一步分析了形态学和临床病理特征,以及免疫组化标志物(CK7、CD117、CD10、P504s、vimentin、CA-IX、CK(AE1/AE3)、EMA、HMB-45、Melan-A和组织蛋白酶K)的表达情况。暗淡至嗜酸性絮状胞质及砂粒体样钙化仅见于Xp11易位性肾细胞癌( P <0.05)。4例pT3a期Xp11易位肾性细胞癌均发生肿瘤性坏死,3年内出现局部复发和远处转移(其中2例死亡)。vimentin、CA-IX、CK(AE1/AE3)和EMA在这两种肾细胞癌中的表达差异有显著性( P <0.05)。 | 魏建国(摘译) 方三高(审校) Yang B Duan H Cao W | 2019 | 临床与实验病理学杂志2019，35，8： | 11 |
| 3 | Estimate of total CO2 output from desertified sandy land in China显示文摘 | Duan Z Xiao H Dong Z | 2001 | Atmospheric Environment2001，35，： | 2 |
| 4 | A molecular roadmap for induced multi-lineage transdifferentiation of fibroblasts by chemical combinations显示文摘 | Xiaoping Han Hao Yu Daosheng Huang Yang Xu Assieh Saadatpour Xia Li Lengmei Wang Jie Yu Luca Pinello Shujing Lai Mengmeng Jiang Xueying Tian Fen Zhang Yanhong Cen Yuko Fujiwara Wei Zhu Bin Zhou Tianhua Zhou Hongwei Ouyang Jianan Wang Guo-Cheng Yuan Shumin Duan Smart H Orkin Guoji Guo | 2017 | Cell Research2017，27，3： | 2 |
| 5 | Intraneuronal beta-amyloid is a major risk factor - novel evidence from the APP/PS1KI mouse model 显示文摘 | Bayer TA Breyhan H Duan K | 2008 | Neurodegener Dis2008，5，34： | 1 |
| 6 | Particulate and Trace Gas Emissions from Open Burning of Wheat Straw and Corn Stover in China 显示文摘 | Li X H Wang S X Duan L | 2007 | Environmental Science and Technology2007，41，17： | 1 |
| 7 | Age-related changes in GluR1 and NNDAR1 glutamate receptor subunit protein immunoreativity in corticocortically projecting neurons in macaque and paras monkeys显示文摘 | HOF PR DUAN H PAGE TL | 2002 | Brain Res2002，928，12： | 1 |
| 8 | Formation and properties of new Ni-based amorphous alloys with critical casting thickness up to 5 mm显示文摘 | XU D H DUAN G JOHNSON W L | 2004 | Acta Materialia2004，52，： | 1 |
| 9 | ATP-induced changes in energy status and membrane integrity of harvested litchi fruit and its relation to pathogen resistance 显示文摘 | YI C QU H X JIANG Y M SHI J DUAN X W JOYCE D C LI Y B | 2008 | Journal of Phytopathology2008，156，： | 1 |
| 10 | Triterpene caffeoyl esters and diterpenes from Celastrus stephanotifolius 显示文摘 | Chen B Duan H Q Yoshihisa T | 1999 | Phytochemistry1999，51，5： | 1 |
| 11 | An integrated simultaneous distillation-extraetion apparatus for the extraction of essential oils from herb materials and its application in Flos Magnoliae 显示文摘 | Wei Y Li B Duan H | 2010 | Biomedical Chromatography2010，24，3： | 1 |
| 12 | Highly polarized photoluminescence and photodetection from single indium phosphide nanowires 显示文摘 | Wang J F Gudiksen M S Duan X F Cui Y Lieberet H M | 2001 | Science2001，293，5534： | 1 |
| 13 | Characterizing the emission of chlorinated/brominated dibenzo-p-dioxins and furans from low- temperature thermal processing of waste printed circuit board 显示文摘 | Duan H B Li J H Liu Y C | 2012 | Environmental Pollution2012，141，2： | 1 |
| 14 | 16S ribosomal DNA analysis and char-acterization of lactic acid bacteria associated with traditional Tibetan Qula cheese made from yak milk显示文摘 | TAN Z F PANG H L DUAN Y H | 2010 | Animal Science Journal2010，81，： | 1 |
| 15 | The use ofphospholipase A(2)to prepare acellular porcine comeal stromaas a tissue engineering scaffold显示文摘 | Wu Z Zhou Y Li N Huang M Duan H Ge J | 2009 | Biomateriais2009，30，21： | 1 |
| 16 | Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracel- lular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles显示文摘 | DEVALAPALLY H DUAN Z SEIDEN MV | 2008 | Clin Cancer Res2008，14，10： | 1 |
| 17 | Fast speciation of mercury in seawater by short-column high-performance liquid chromatography hyphenated to inductively coupled plasma spectrometry after on-line cation exchange column preconcentration 显示文摘 | Jia X Y Gong D R Han Y Wei C Duan T C Chen H T | 2012 | Talanta2012，88，： | 1 |
| 18 | Triterpene caffeoyl esters and diterpenes from Celastrus stephanotifolius显示文摘 | Chen B Duan H | | 0，，5： | 1 |
| 19 | Electronic structure of carbon nanotube in the growth显示文摘 | ZHOU G DUAN W H GU B L | 2001 | Chem J Chinese U2001，22，11： | 1 |
| 20 | Core-shell struc- ture design of pulverized expandable graphite particles and their application in flame-retardant rigid polyurethane foams显示文摘 | Duan H J Kang H Q Zhang W Q | 2014 | Polym Int2014，63，1： | 1 |
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