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| 1 | Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide显示文摘Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing positive and protective effects in several different tissues, including pancreas, heart or even brain. This gut secreted hormone plays a potent insulinotropic activity and an important role in maintaining glucose homeostasis. Furthermore, growing evidences suggest the occurrence of several commonalities between T2 D and neurodegenerative diseases, insulin resistance being pointed as a main cause for cognitive decline and increased risk to develop dementia. In this regard, it has also been suggested that stimulation of brain insulin signaling may have a protective role against cognitive deficits. As GLP-1 receptors(GLP-1R) are expressed throughout the central nervous system and GLP-1 may cross the blood-brain-barrier, an emerging hypothesis suggests that they may be promising therapeutic targets against brain dysfunctional insulin signaling-related pathologies. Importantly, GLP-1 actions depend not only on the direct effect mediated by its receptor activation, but also on the gut-brain axis involving an exchange of signals between both tissues via the vagal nerve, thereby regulating numerous physiological functions(e.g., energy homeostasis, glucose-dependent insulin secretion, as well as appetite and weight control). Amongst the incretin/GLP-1 mimetics class of anti-T2 D drugs with an increasingly described neuroprotective potential, the already marketed liraglutide emerged as a GLP-1R agonist highly resistant to dipeptidyl peptidase-4 degradation(thereby having an increased half-life) and whose systemic GLP-1R activity is comparable to that of native GLP-1. Importantly, several preclinical studies showed anti-apoptotic, anti-inflammatory, anti-oxidant and neuroprotective effects of liraglutide against T2 D, stroke and Alzheimer disease(AD), whereas several clinical trials, demonstrated some surprising benefits of liraglutide on weight loss, microglia inhibition, behavior and cognition, and in AD biomarkers. Herein, we discuss the GLP-1 action through the gut-brain axis, the hormone's regulation of some autonomic functions and liraglutide's neuroprotective potential. | Emanuel Monteiro Candeias Inês Carolina Sebastio Susana Maria Cardoso Sónia Catarina Correia Cristina Isabel Carvalho Ana Isabel Plácido Maria Sancha Santos Catarina Resende Oliveira Paula Isabel Moreira Ana Isabel Duarte | 2015 | World Journal of Diabetes2015，6，6： | 9 |
| 2 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 3 | Extration of ribosomal RNA and genomic DNA from soil for studying the diversity of the indigenous bacterial community 显示文摘 | Duarte G F Rosado A S Seldin L | 1998 | Journal of Microbiological Methods1998，32，： | 2 |
| 4 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 5 | Full survival of paraquat-exposed rats after treatment with sodium salicylate显示文摘 | R.J. Dinis-Oliveira C. Sousa F. Remi?o J.A. Duarte A. Sánchez Navarro M.L. Bastos F. Carvalho | 2007 | Free Radical Biology and Medicine2007，，7： | 2 |
| 6 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 7 | CO 2 emissions embodied in international trade: evidence for Spain显示文摘 | Julio Sánchez-Chóliz Rosa Duarte | 2003 | Energy Policy2003，，18： | 2 |
| 8 | SCIENCE OF WINNING SOCCER:EMERGENT PATTERN-FORMING DYNAMICS IN ASSOCIATION FOOTBALL显示文摘Quantitative analysis is increasingly being used in team sports to better understand performance in these stylized,delineated,complex social systems.Here,the authors provide a first step toward understanding the pattern-forming dynamics that emerge from collective offensive and defensive behavior in team sports.The authors propose a novel method of analysis that captures how teams occupy sub-areas of the field as the ball changes location.The authors use this method to analyze a game of association football(soccer) based upon a hypothesis that local player numerical dominance is key to defensive stability and offensive opportunity.The authors find that the teams consistently allocated more players than their opponents in sub-areas of play closer to their own goal.This is consistent with a predominantly defensive strategy intended to prevent yielding even a single goal.The authors also find differences between the two teams' strategies:while both adopted the same distribution of defensive,midfield,and attacking players(a 4:3:3 system of play),one team was significantly more effective in maintaining both defensive and offensive numerical dominance for defensive stability and offensive opportunity.That team indeed won the match with an advantage of one goal(2 to 1) but the analysis shows the advantage in play was more pervasive than the single goal victory would indicate.The proposed focus on the local dynamics of team collective behavior is distinct from the traditional focus on individual player capability.It supports a broader view in which specific player abilities contribute within the context of the dynamics of multiplayer team coordination and coaching strategy.By applying this complex system analysis to association football,the authors can understand how players' and teams' strategies result in successful and unsuccessful relationships between teammates and opponents in the area of play. | VILAR Luís ARAUJO Duarte DAVIDS Keith BAR-YAM Yaneer | 2013 | Journal of Systems Science & Complexity2013，26，1： | 2 |
| 9 | Paraquat Poisonings: Mechanisms of Lung Toxicity, Clinical Features, and Treatment显示文摘 | R. J. Dinis-Oliveira J. A. Duarte A. Sánchez-Navarro F. Remi?o M. L. Bastos F. Carvalho | 2008 | CRC Critical Reviews in Toxicology2008，，1： | 2 |
| 10 | Silanes and rare earth salts as chromate replacers for pre-treatments on galvanised steel 显示文摘 | FERREIRA M G S DUARTE R G MONTEMOR M F | 2004 | Electrochimica Acta2004，49，1718： | 1 |
| 11 | Nutrient and temperature control of the contribution of picoplankton to phytoplankton biomass and production显示文摘 | Agawin N S R Duarte C M Agustí S | 2000 | Limnology and Oceanography2000，45，： | 1 |
| 12 | Involvement of the pancreas in AIDS: a prospective study of 109 post-mortems显示文摘 | Ethel Z Chehter Maria Antonieta Longo Antonio A Laudanna Maria Irma S Duarte | 2000 | AIDS2000，，13： | 1 |
| 13 | CO2 emissions embodied in international trade:evidence for Spain显示文摘 | Sánchez-Chóliz J Duarte R | | 0，，18： | 1 |
| 14 | Ultra-trace determination of per- sistent organic pollutants in arctic ice using stir bar sorp- tive extraction and gas chromatography coupled to mass spectrometry 显示文摘 | Lacortea S Quintana J Taulera R Ventura F Tovar- Sanchez A Duarte CM | 2009 | J Chromatogr A2009，1216，49： | 1 |
| 15 | RNA binding by the Wilms tumor suppressor zinc finger proteins显示文摘 | CARICASOLE A DUARTE A LARSSON S H | 1996 | Proc Natl Acad Sci USA1996，93，15： | 1 |
| 16 | Development and application of a capillary electrophoresis based method for the simultaneous screening of six antibiotics in spiked milk samples 显示文摘 | Santos S M Henriques M Duarte A C | 2007 | Talanta2007，71，2： | 1 |
| 17 | Response of a Mediterranean phytoplankton community to increased nutrient inputs: a mesocosm experiment显示文摘 | Duarte C M Agusti S Agawln S R | 2000 | Marine Ecology Progress Series2000，195，： | 1 |
| 18 | Expression of alpha-hemoglobin stabilizing protein gene during human erythropoiesis显示文摘 | DOS SANTOS C O DUARTE A S SAAD S T | 2004 | Exp Hematol2004，32，2： | 1 |
| 19 | Paraquat poisonings:mechanisms of lung toxicity,clinical features and treatment显示文摘 | Dinis-Oliveira RJ Duarte JA Sánchez-Navarro A | | 0，，： | 1 |
| 20 | Pataquat poisoning:mechanisms of lung toxicity,clinical features,and treatment显示文摘 | Dinis-Oliveira RJ Duarte JA Sánchez-Navarro A | 2008 | Crit Rev Toxicol2008，38，1： | 1 |
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