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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 3 | lntensity correlation functions for the colored gain-noisc model of dye lasers显示文摘 | TORAL R SAN MIGUEL M | 1990 | Phys Rev1990，42，11： | 1 |
| 4 | Noisy continuous- opinion dynamics显示文摘 | Pineda M Toral R Hernandez-Garcia E | 2009 | Journal of Statistical Mechanics: Theory and Experiment2009，，： | 1 |
| 5 | Optimization of the Electrocoagulation Process for the Removal of Copper, Lead and Cadmium in Natural Waters and Simulated Wastewater显示文摘 | Escobar Claudio Soto - Salazar Cesar Ines Toral M | 2006 | Journal of Environmental Management2006，81，： | 1 |
| 6 | Enhancement of stochastic resonance:The role of non-Gaussian noise 显示文摘 | FUENTES M A TORAL R WIO H S | 2001 | Physica A2001，295，： | 1 |
| 7 | Analysisof virtual communities supporting OSS projects using so- cial network analysis 显示文摘 | Toral S L Martiinez- Torres M R Barrero F | 2010 | Information and Software Technology2010，52，3： | 1 |
| 8 | Reactivepower and energy measurement in the frequency domain usingrandom pulse arithmetic显示文摘 | TORAL S L QUERO J M FRANQUELO L G | 2001 | IEE Proceeding:Science Measurement and Technology2001，48，2： | 1 |
| 9 | Interactive Multimedia Teaching of Digital Signal Processors显示文摘 | S L Toral F Barrero M R Martinez - Tortes | 2007 | Computer Applications in Engineering Education2007，，1： | 1 |
| 10 | Polarographic Behaviour and Determination of Ranitidine in Phar maceutical Formulations and Urine 显示文摘 | RICHTER P TORAL M I MUNOZ-VARGAS F | 1994 | Analyst1994，119，： | 1 |
| 11 | The role of Internet in the development of future software projects显示文摘 | MARTINEZ-TORRES M R TORAL S L BARRERO F | 2010 | Internet Research2010，20，1： | 1 |
| 12 | Nonequilibrium transition in complex networks:a model of social interactions显示文摘 | Klemm K Eguiluz V M Toral R | 2003 | Physical Review E2003，67，02： | 1 |
| 13 | 显示文摘 | CISZAK M MARINO F TORAL R | 2004 | Phys Rev Lett2004，93，： | 1 |
| 14 | Global culture:a noise-induced transition in finite systems显示文摘 | Klemm K Eguiluz V M Toral R | 2003 | Physical Review E2003，67，04： | 1 |
| 15 | Analysis of Virtual Communities supporting OSS Projects using Social Network Analysis显示文摘 | Toral S L Martinez-Torres M R Barrero F | | 0，，： | 1 |
| 16 | Enhancement of stochastic resonance:the role of non Gaussian noises显示文摘 | Fuentes M A Toral R Wio H S | 2001 | Physica A2001，295，12： | 1 |
| 17 | Effective Markovian approximation for non-Gaussian noises:a path integral approach显示文摘 | Fuentes M A Wio H S Toral R | 2002 | Physica A2002，303，12： | 1 |
| 18 | External collaboration patterns of research institutions using shared publications in the web of science显示文摘 | Toral S L Bessis N Martínez-Torres M R | | 0，，： | 1 |
| 19 | Determination of Platinum and Palladium by Second Derivative Spectrophotometry Using 3-(2'-Thiazolylazo)-2,6-Diaminopyridine as Chromophore Ligand显示文摘 | Toral M I Richter P Lara N | 2000 | Analytical letters2000，33，1： | 1 |
| 20 | Simultaneous determination of iron and ruthenium as ternary complexes by extractive second derivative spectrophotometry显示文摘 | Toral M I Richter P Tapia A E | 1999 | Talanta1999，50，： | 1 |
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