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| 1 | Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass显示文摘Background Ethnicity is shown to be one of important factors affacting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations.Methods The studied restriction fragment length polymorphisms were Bsa H Ⅰ of the calcium-sensing receptor gene, Sac Ⅰ of the α2HS-glycoprotein (AHSG) gene, Pvu Ⅱ and Xba Ⅰ of the oestrogen receptor α gene, Apa Ⅰ of the vitamin D receptor (VDR) gene and BstB Ⅰ of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results Two polymorphisms, AHSG- Sac Ⅰ and VDR- Apa Ⅰ, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large. | Volodymyr Dvornyk LIU Peng-yuan LONG Ji-rong ZHANG Yuan-yuan LEI Shu-feng Robert R Recker DENG Hong-wen | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 2 | Differentiation of Caucasians and Chinese at bone mass candidate genes: implication for ethnic difference of bone mass显示文摘 | Dvornyk V Liu XH Shen H | 2003 | Ann Hum Genet2003，67，3： | 1 |
| 3 | Genes involved in the regulation of vascular homeostasis determine renal survival rate in patients with chronic glomerulonephritis显示文摘 | Olga Litovkina Elena Nekipelova Volodymyr Dvornyk | 2014 | Gene2014，546，1： | 1 |
| 4 | Low nucleotide diversity at the pall locus in the widely distribu- ted Pinus sylvestris显示文摘 | DVORNYK V SIRVIO A MIKKONEN M | 2002 | Mol Biol Evol2002，19，2： | 1 |
| 5 | Low nucleotide diversity at the pall locus in the widely distributed Pinus sylvestris显示文摘 | Dvornyk V Sirviu A Mikkonen M | 2002 | Mo- lecular Biology and Evolution2002，19，： | 1 |
| 6 | Interaction effects between estrogen receptor α gene, vitamin D receptor gene, age, and sex on bone mineral density in Chinese显示文摘 | Jirong Long Pengyuan Liu Yuanyuan Zhang Hui Shen Yongjun Liu Volodymyr Dvornyk Hong-Wen Deng | 2003 | Journal of Human Genetics2003，，10： | 1 |
| 7 | Origin and evolution of circadianclock genes in prokaryotes显示文摘 | Dvornyk V Vinogradova O Nevo E | | 0，，05： | 1 |
| 8 | Origin and evolution of circadian clock genes in prokaryotes显示文摘 | Dvornyk V Vinogradova O Nevo E | 2003 | Proe Natl Aead Sci USA2003，100，5： | 1 |
| 9 | Differentiation of caucasians and asians at bone mass candidate genes:implication for ethnic difference of bone mass显示文摘 | Dvornyk V Liu XH Shen H | 2003 | Ann Hum Genet2003，67，3： | 1 |
| 10 | Differentiation of Caucasians and Chinese at bone mass candidate gene: implication for ethnic difference of bone mass显示文摘 | Dvornyk V Liu XH Shen H | 2003 | Ann Hum Genet2003，67，3： | 1 |
| 11 | Current limitations of SNP data from the public domain for studies of complex disorders:a teat for ten candidate genes for obesity and osteoporosis显示文摘 | Dvornyk V Long J R Xiong D H | 2004 | BMC Genet2004，5，1： | 1 |
| 12 | Differertiation of Caucasians and Chinese at bone mass candidate genes implication for ethnic difference of bone mass显示文摘 | Dvornyk V Liu XH Shen H | 2003 | Ann Hum Genet2003，67，3： | 1 |
| 13 | 绝经对血液单核细胞基因表达谱的影响:基因芯片初步研究(英文)显示文摘绝经是女性一生中很重要的生理现象之一,它能增加一系列复杂免疫、神经退化、新陈代谢和心血管方面的疾病。血液单核细胞能分化成各种各样的细胞,这些细胞在组织形态发生和免疫应答方面起着很重要的作用。本研究中采用了包含大约14,500个基因探针的Affymetrix Human U133A基因芯片来研究健康的绝经前和绝经后女性外周血液单核细胞中的基因表达谱。样本之间的对比分析表明有20个基因上调,20个基因下调。其中的28个基因根据它们的生物过程如细胞繁殖、免疫应答、细胞代谢等等被分成了6个主要的GO类别;剩下的12个基因其生物学功能还没有被鉴定。研究结果支持了我们的假设:血液单核细胞的功能状态确实受到绝经的影响,而且由此带来的改变可能是由全基因组范围的基因表达谱而决定的。本研究中鉴定的一些差异表达基因有可能作为以后研究与绝经相关的系统免疫、神经退化和心血管疾病的候选基因研究。此工作是这个研究方向的第一次尝试,为将来的进一步研究奠定了基础。 | Dvornyk Volodymyr 刘耀中 陆燕 沈汇 Lappe Joan M 雷署丰 Recker Robert R 邓红文 | 2007 | Journal of Genetics and Genomics2007，34，11： | 0 |
| 14 | Genes of tumor necrosis factors and their receptors and the primary open angle glaucoma in the population of Central Russia显示文摘AIM:To examine the association of genetic polymorphisms(-308)G/A TNFα,(+250)A/G Ltα,(+36)A/G TNFR1,(+1663)A/G TNFR2 with the development of primary open angle glaucoma(POAG) among people in Central Russia.METHODS:The study sample included 443 individuals,of which 252 patients with POAG and 191 individuals in the control group.Genotyping of(-308)G/A TNFα,(+250)A/G Ltα,(+36)A/G TNFR1,(+1663)A/G TNFR2 was performed using polymerase chain reaction.The distribution of alleles and genotypes of the studied DNA markers in the groups was examined by 2×2 contingency tables and χ2 with the Yates' s correction for continuity and odds ratios(OR) with 95% confidence intervals(CI).RESULTS:Allele(-308)G TNFα(Р=0.01,OR=1.78,95%CI 1.12-2.85) was identified as a risk factor for POAG.Homozygotes(-308) AA TNFα are at a lowest risk for development of the disease(Р=0.01,OR=0.0005).The following combination of genetic variants of cytokines were associated with a reduced risk of POAG:(+1663)A TNFR2 and(+250)G Ltα(OR=0.34)CONCLUSION:Genetic polymorphisms(-308)G/A TNFα,(+250)A/G Ltα,(+1663)A/G TNFR2 associated with the development of POAG in the population of Central Russia. | Evgeniya Tikunova Veronika Ovtcharova Evgeny Reshetnikov Volodymyr Dvornyk Alexey Polonikov Olga Bushueva Mikhail Churnosov | 2017 | International Journal of Ophthalmology(English edition)2017，10，10： | 0 |
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