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| 1 | Deciphering the role of hedgehog signaling in pancreatic cancer显示文摘Pancreatic cancer,mostly pancreatic ductal adenocarcinoma(PDAC),is a leading cause of cancer-related death in the US,with a dismal median survival of 6 months.Thus,there is an urgent unmet need to identify ways to diagnose and to treat this deadly cancer.Although a number of genetic changes have been identified in pancreatic cancer,their mechanisms of action in tumor development,progression and metastasis are not completely understood.Hedgehog signaling,which plays a major role in embryonic development and stem cell regulation,is known to be activated in pancreatic cancer;however,specific inhibitors targeting the smoothened molecule failed to improve the condition of pancreatic cancer patients in clinical trials.Furthermore,results regarding the role of Hh signaling in pancreatic cancer are controversial with some reporting tumor promoting activities whereas others tumor suppressive actions.In this review,we will summarize what we know about hedgehog signaling in pancreatic cancer,and try to explain the contradicting roles of hedgehog signaling as well as the reason(s) behind the failed clinical trials.In addition to the canonical hedgehog signaling,we will also discuss several non-canonical hedgehog signaling mechanisms. | Dongsheng Gu Kelly E Schlotman Jingwu Xie | 2016 | The Journal of Biomedical Research2016，30，5： | 7 |
| 2 | Effect of monovalent anions on cationic Gemini micro-emulsion显示文摘Micro-emulsion usually consists of water, oil, surfactants and co-surfactants, and each component has an effect on the phase behavior and solubilization of the micro-emulsion. When the surfactant in the micro-emulsion system is quaternary ammonium cationic Gemini surfactant, the surfactant mainly combines with the anions in the salt. With the increase of salt concentration, the phase transformation of Winsor I → Winsor III → Winsor II occurred, but the optimum salinity and salt width are different because of the type of salt. The effects of 5 different kinds of monovalent anions, including C_6H_5SO_3^-, I-, Br-, NO_3^- and Cl-, on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are researched by Winsor phase diagram. It is found that the effects of organic anions C_6H_5SO_3-and I-on the phase behavior and solubilization of quaternary ammonium cationic Gemini micro-emulsion are most significant, and the effects of Br-, NO_3^- and Cl-are less significant. Meanwhile, when the optimum solubilization is achieved, the amount of sodium benzoate is the least, indicating that the organic anion has stronger self-organization behavior with quaternary ammonium cationic Gemini surfactants. | Yinglu Gu Shuang Chen Hui'e Liu Yubin Wang Pingping Zhou | 2018 | Chinese Journal of Chemical Engineering2018，26，12： | 6 |
| 3 | Danggui-shaoyao-san, a traditional Chinese medicine prescription, alleviates the orthodontic pain and inhibits neuronal and microglia activation显示文摘 | Li Hongshi Gu Zexu Wu Li'an Xia Liang Zhou Kecheng E Lingling Wang Dongsheng Kou Junping Liu Hongchen | 2014 | Chinese Medical Journal2014，，20： | 4 |
| 4 | The diversity of Malassezia yeasts confirmed by rRNA sequence and nuclear DNA comparisons显示文摘 | Guillot J Guého E | 1995 | Antonie Leeuwenhoek1995，67，： | 2 |
| 5 | Combustion synthesis and lumines-cence properties ofDy3+-doped MgO nanoerystals显示文摘 | GU F WANG S E L0 M K | 2004 | J Cryst Growth2004，260，34： | 1 |
| 6 | Ethanol increases carotenoid production in Phaffia rhodozyma 显示文摘 | Gu W L An G H Johnson E A | 1997 | Journal of Industrial Microbiology & Biotechnology1997，19，： | 1 |
| 7 | Worst case propagated uncertainty of multidisciplinary systems in robust design optimization显示文摘 | GU X Y RENAUD J E BATILL S M | 2000 | Structural and Multidisciplinary Optimization2000，20，3： | 1 |
| 8 | Wrist-bridging versus nonbridging external fixation for displaced distal radius fractures: a randomized assessor-blind clinical trial of 38 patients followed for 1 year 显示文摘 | Atroshi I Brogren E Larsson GU | 2006 | Acta Orthop2006，77，3： | 1 |
| 9 | Environmental risk as- sessment: A critical approach of the European TGD in an in situ application 显示文摘 | Gu e rit 1 Boequen e G James A | 2008 | Ecotoxicology and Environmental Safety2008，71，9： | 1 |
| 10 | Influence of pH and carrageenan type on properties of fl-lactoglobulin stabilized oil-in- water emulsions显示文摘 | GU S Y DECKER E A MCCLEMENTS D J | 2005 | Food Hydrocolloids2005，19，1： | 1 |
| 11 | Genetic variation in anti-herbivore chemical defenses in an invasive plant显示文摘 | Wang Y Siemann E Wheeler G S Zhu L Gu X Ding J | | 0，，： | 1 |
| 12 | Implicit uncertainty propagation for robust collaborative optimization显示文摘 | GU X Y RENAUD J E PENNINGER C L | 2006 | Journal of Mechanical Design2006，128，4： | 1 |
| 13 | A Simple Proximity Sensor for Metal Surface Quality Monitoring显示文摘 | Gu C Peiponen K E Silvennoinen R | 1994 | Precision Engineering1994，16，3： | 1 |
| 14 | The genus Malassezia with description of four new species显示文摘 | Guého E Midgley G Guillot J | 1996 | Antonie Leeuwenhoek1996，69，： | 1 |
| 15 | Transparent light-emitting devices显示文摘 | Bulovic V Gu G Burrows P E | 1996 | Nature1996，380，6569： | 1 |
| 16 | Common vari- ants in epithelial sodium channel genes contribute to salt sensitivity of blood pressure: The GenSalt study 显示文摘 | ZHAO Q GU D HIXSON J E | 2011 | Circ Cardiovasc Genet2011，4，： | 1 |
| 17 | Application of multi-component biopolymer layers to improve the freeze-thaw stability of oil-in-water emulsions: β-Lactoglobulin-ι-carrageenan-gelatin显示文摘 | Gu Y S Decker E A Julian McClements D | 2007 | Journal of Food Engineering2007，80，4： | 1 |
| 18 | Effects of dopamine and norepinephrine on systemic and hepatosplanchnic hemodynamics,oxygen exchange,and energy balance in vasoplegic septic patients显示文摘 | Gu(e)rin JP Levraut J Samat-Long C | | 0，，： | 1 |
| 19 | Plasma and BAL cytokine response to corticosteroid rescue treatment in late ARDS 显示文摘 | Meduri GU Headley S Tolley E | 1995 | Chest1995，108，5： | 1 |
| 20 | Silencing oncogene expression in cervical cancer stem-like cells inhibits their cell growth and self-renewal ability显示文摘 | Gu W Yeo E Mc Millan N | 2011 | Cancer Gene Therapy2011，18，12： | 1 |
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