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| 1 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 2 | Research on Benefit Distribution Mechanism of Farmers’ Specialized Cooperative Economic Organization显示文摘On the basis of conducting survey in Jiaonan City,the thesis analyzes benefit distribution mechanism of farmers’ specialized cooperative economic organizations:firstly,the benefit correlation is mainly the contract correlation;secondly,the profit distribution is mainly the dividend;thirdly,patronage refund has many connotations;fourthly,the public accumulation has not yet been quantified to individual;fifthly,the government support capital is ill-defined.Based on these,the measures are put forward in order to improve benefit distribution pattern of farmers’ specialized cooperative economic organizations:firstly,reform structure of property rights and realize farmers’ ownership;secondly,change mode of decision-making,and realize farmers’ control;thirdly,increase turnover rebate and realize farmers’ benefiting;fourthly,quantify public accumulation and government support fund. | SUN Hao-jie1,WANG Zheng-bing2,WANG Yun-hui3 1.School of Economics and Management,Chang’ an University,Xi’an 710064,China 2.College of Economics and Management,Northwest A & F University,Yangling 712100,China 3.Publicity Office of Party Committee,Xi’an Branch of the People’ Bank of China,Xi’an 710064,China | 2011 | Asian Agricultural Research2011，3，4： | 5 |
| 3 | A Solution to Old Problems显示文摘I work in the Dalian Development Zone. Although the central government did not invest a penny, the zone’s annual revenue is some 5 billion yuan. In 2003, it surpassed 6 billion yuan. There are many solely foreign-invested enterprises in the development zone-more than 300 are Japanese, and there are many Sino-foreign joint ventures. The annual profits of 70 million yuan come mostly from these joint ventures.I think the development zone will play an important role in the revital-ization of industries in the Northeast. | LIU GUOCHEN deputy director of the Dalian Economic and Technology Development Zone Administrative Committee, and a PHD of Economics. | 2004 | China Today2004，53，3： | 2 |
| 4 | Datermination of Methimazole and Carblmazole by Flow-Injection with Chemiluminescence Detection Based on the Inhibition of the Cu( I )-Catalysed Lumino-Hydrogen Peroxide Reaction显示文摘 | Economou A Tzanavaras P D Notou M | 2004 | Analytica Chimica Acta2004，505，1： | 1 |
| 5 | Perinatal changes of brain-derived neurotrophic factor in pre- and full term neonates显示文摘 | Malamitsi-Puchner A Economous E Rigopoulou O | 2004 | Early Hum Dev2004，76，1： | 1 |
| 6 | Double beta decay of 238U 显示文摘 | Economou T E Cowan G A | 1991 | Phys Rev Lett1991，67，23： | 1 |
| 7 | Soluble vascular endothelial growth factor receptor-1 in intrauterine growth restricted fetuses and neonates 显示文摘 | Boutsikou T Malamitsi-Puchner A Economou E | 2006 | Early Hum Dev2006，82，： | 1 |
| 8 | Nisin-EDTA ITeatmentand modified atmosphere packaging to increase fresh chicken meat shelf-life显示文摘 | ECONOMOU T POURNIS N NTZIMANI A | 2009 | Food Chem2009，114，4： | 1 |
| 9 | Long term audiological evaluation of beta-thalassemic patients 显示文摘 | Kontzoglou G Koussi A Economou M | 2004 | Acta Otorhinolaryngol Belg2004，58，2： | 1 |
| 10 | Tumor necrosis factor- alpha-related intraperitoneal release of CA 125 in cirrhotic patients with sterile ascites显示文摘 | Kalambokis G Kostoula A Economou M | 2005 | Clin Chem2005，51，11： | 1 |
| 11 | Nisin-EDTA treatments and modified atmosphere packaging to increase fresh chicken meat shelf-life 显示文摘 | Economou T Pournis N Ntzimani A | 2009 | Food Chemistry2009，114，4： | 1 |
| 12 | Inverted repeat structure of the Sry locus in mice显示文摘 | Gubbay J Vivian N Economou A | 1992 | Proe Natl Acad Sci USA1992，89，17： | 1 |
| 13 | Effects of a 7-day treatment with midodrine in non-azotemic cirrhotic patients with and without ascites显示文摘 | Kalambokis C Fotopoulos A Economou M | 2007 | J Hepatol2007，46，2： | 1 |
| 14 | Azalea regeneration fromcallus culture显示文摘 | Economous A S Read P E Spanoudaki M J | 1988 | Acta horticuhurae1988，226，1： | 1 |
| 15 | Measurable serum markers of oxidative stress response in women with endometriosis显示文摘 | Augoulea A Christodoulakos G Economou EV | 2009 | Fertility and Sterility2009，91，1： | 1 |
| 16 | Following the leader: bacterial protein export through the Sec pathway 显示文摘 | Economou A | 1999 | Trends Microbiol1999，7，8： | 1 |
| 17 | Journal of Chromatography A显示文摘 | Economou A Botitsi H Antoniou S Tsipi D | 2009 | 1216 : 58562009，1216，： | 1 |
| 18 | The Growth of the City : An Introduction Research Project 显示文摘 | Estimates from a 'Repeat Income' Model Forthcoming: American Economic Review BURGESS ERNEST W | 1925 | The Trend of Population1925，，18： | 1 |
| 19 | Supplemental lighting in thepropagation of deciduous Azaleas显示文摘 | READ P E ECONOMOU A | 1982 | Proc Int Plant Prep Soc1982，32，： | 1 |
| 20 | Economic Regionalism: A Win-Win Option显示文摘Economic regionalism in East Asia lags far behind the quickened pace of southward thrust of the North America Free Trade Area (NAFTA) and eastern extension of the European Union. Despite aspirations for regional economic cooperation on the part of the nations concerned , differences in their stage of economic development, the burning issues facing them and varying domestic pressures against trade liberalization have resulted in insufficient urgency and driving force for | Zhao Jinpong is a Research Professor and Director of Department for Foreign Economic Studies, Development Research Center of the State Council. | 2003 | Contemporary International Relations2003，13，11： | 1 |
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