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| 1 | 每日1次利拉鲁肽与每日2次艾塞那肽治疗2型糖尿病比较:一项为期26周的随机、平行组、多国开放标记试验(LEAD-6)显示文摘背景与大多数抗高血糖药物不同,胰高血糖素样肽-1(GLP-1)受体激动剂的药理作用依赖于葡萄糖水平,并且有助于减轻患者体重。本研究比较了利拉鲁肽(一种人GLP-1类似物)与艾塞那肽(一种基于醋酸艾塞那肽的GLP-1受体激动剂)治疗2型糖尿病的疗效和安全性。方法对于用最大耐受剂量二甲双胍或(和)磺脲仍控制不良的2型糖尿病成年患者,根据之前服用的抗糖尿病药物进行分层,并随机分配这些患者额外接受利拉鲁肽1.8mg每El1次(n=233)或艾塞那肽10μg每日2次(n=231),进行为期26周的开放标记、平行组、多国(15个国家)研究。主要终点是糖化血红蛋白(HbA1c)水平的变化,疗效分析采用意向性治疗分析。本试验在Clinical Trial.gov注册,注册号为NCT00518882。结果受试者的HbA1c平均基线水平为8.2%。与艾塞那肽相比,利拉鲁肽能显著降低HbA1c平均水平[-1.12%(s=0.08%)vs-0.79%(s=0.08%);疗效差异估计值为-0.33%,95%CI-0.47%~-0.18%;P〈0.0001],并且利拉鲁肽组有更多患者HbA1c水平低于7%(54%vs543%;OR 2.02,95%CI 1.31~3.11;P=0.0015)。利拉鲁肽降低平均空腹血糖的能力也显著优于艾塞那肽[-1.61mmol/Lb=0.20)vs-0.60mmol/L(s=0.20);疗效差异估计值为-1.01mmol/L,95%CI-1.37—-0.65;P〈0.0001],但是其降低早餐和晚餐后血糖的能力较艾塞那肽差。两种药物促进患者体重减轻的作用相似(利拉鲁肽组~3.24kg vs艾塞那肽组-2.87地)。耐受性均较好,但与艾塞那肽组相比,利拉鲁肽组患者恶心的持续时间较短(估计的治疗相关事件率比值为0.448,P〈0.0001),轻度低血糖的发生率也较低(每患者每年的事件发生数为1.93vs2.60;发生率比值为0.55,95%C10.34~0.88:P=0.0131;轻度低血糖的发生率为25.5%掷33.6%)。2例同时注射艾塞那肽和一种磺脲类药物的患者发生了严重的低血糖。结论相对于艾塞那肽每日2次,利拉鲁肽每日1次能显著改善血糖控制水平,且患者的耐受性更好。研究结果提示利拉鲁肽或许是2型糖尿病的一种治疗选择,特别是在减轻体重和低血糖风险作为主要考虑因素的情况下。 | John B Buse Julia Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde 赵乐(译) | 2009 | 世界临床医学2009，，11： | 3 |
| 2 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet2009，，9683： | 2 |
| 3 | Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)显示文摘 | John B Buse Julio Rosenstock Giorgio Sesti Wolfgang E Schmidt Eduard Montanya Jason H Brett Marcin Zychma Lawrence Blonde | 2009 | The Lancet . 2009 (9683)2009，，9683： | 1 |
| 4 | Do fanning exposures cause or prevent asthma? Results from a study of adult Norwegian farmers 显示文摘 | EDUARD W DOUWER J OMENAAS E | 2004 | Thorax2004，59，： | 1 |
| 5 | Detection of cavitation in hydraulic turbines显示文摘 | XAVIER E EDUARD E MOHAMED F | 2006 | Mechanical Systems and Signal Processing2006，，20： | 1 |
| 6 | Preparation of Sb2S3 nanostruc- tures by the ionic liquid assisted low power sonochemical method显示文摘 | Pablo S E Eduard M S | 2010 | Mater Lett2010，64，23： | 1 |
| 7 | Glucocerebrosidase mutations in subjects with parkinsonism显示文摘 | Alicia Lwin Eduard Orvisky Ozlem Goker-Alpan Mary E LaMarca Ellen Sidransky | 2003 | Molecular Genetics and Metabolism2003，，1： | 1 |
| 8 | Detect ion of cavitation in hydraulic turbines 显示文摘 | Xavier E Eduard E Mohamed F | 2006 | Mechanical Sys- tems and Signal Processing2006，20，4： | 1 |
| 9 | Low-level laser therapy for treatment of temporomandibular joint pain : a double-blind and pla- cebo-controlled trial显示文摘 | Rudiger E Renato B Eduard P | 2008 | Oral Surg Oral Med Oral Pathol Oral Ra- diol Endod2008，105，4： | 1 |
| 10 | Water circulation control during once-through boiler start-up 显示文摘 | Eduard E | 2004 | Control Engineering Practice2004，，12： | 1 |
| 11 | Failure investigation of a large pumpturbinerunner 显示文摘 | Eduard E Carme V | 2012 | Engineering Failure Analysis2012，2，23： | 1 |
| 12 | Condition monitoring of pump-turbines:new challenges显示文摘 | Eduard E Carme V | 2015 | Measurement2015，67，2： | 1 |
| 13 | The variability of regional airflow obstruction within the lungs of patients with asthma: As sessment with hyperpolarized helium-3 magnetic resonance imaging显示文摘 | Eduard E Talissa A James T | 2007 | J Allergy Clin Immunol2007，119，5： | 1 |
| 14 | Detection of cavitation in hydraulic turbines 显示文摘 | XAVIER E EDUARD E MOHAMED F | 2006 | Mechanical Systems and Signal Processing2006，20，4： | 1 |
| 15 | Non-destructive banana ripeness determination using a neural network-based electronic nose显示文摘 | EDUARD L E | 1999 | Measure Sci Technol1999，，10： | 1 |
| 16 | Detection of Cav- itation in Hydraulic Turbines 显示文摘 | Xavier E Eduard E Mohamed F | 2006 | Mechanical System and 3ignal Processing2006，20，4： | 1 |
| 17 | Wet air oxidation in acatalytic membrane reactor:Model and industrial wastewaters insingle tubes and multichannel contactors显示文摘 | Eduard E I Sylvain M Emmanuel L | 2007 | Applied Catalysis B:Environmental2007，69，34： | 1 |
| 18 | Quantitative feedback design for tracking error tolerance 显示文摘 | EDUARD E | 2000 | Automatica2000，36，2： | 1 |
| 19 | Resection of complex pancreatic injuries: Benchmarking postoperative complications using the Accordion classification显示文摘AIM To benchmark severity of complications using the Accordion Severity Grading System(ASGS) in patients undergoing operation for severe pancreatic injuries. METHODS A prospective institutional database of 461 patients with pancreatic injuries treated from 1990 to 2015 was reviewed. One hundred and thirty patients with AAST grade 3, 4 or 5 pancreatic injuries underwent resection(pancreatoduodenectomy, n = 20, distal pancreatectomy, n = 110), including 30 who had an initial damage controllaparotomy(DCL) and later definitive surgery. AAST injury grades, type of pancreatic resection, need for DCL and incidence and ASGS severity of complications were assessed. Uni-and multivariate logistic regression analysis was applied. RESULTS Overall 238 complications occurred in 95(73%) patients of which 73% were ASGS grades 3-6. Nineteen patients(14.6%) died. Patients more likely to have complications after pancreatic resection were older, had a revised trauma score(RTS) < 7.8, were shocked on admission, had grade 5 injuries of the head and neck of the pancreas with associated vascular and duodenal injuries, required a DCL, received a larger blood transfusion, had a pancreatoduodenectomy(PD) and repeat laparotomies. Applying univariate logistic regression analysis, mechanism of injury, RTS < 7.8, shock on admission, DCL, increasing AAST grade and type of pancreatic resection were significant variables for complications. Multivariate logistic regression analysis however showed that only age and type of pancreatic resection(PD) were significant. CONCLUSION This ASGS-based study benchmarked postoperative morbidity after pancreatic resection for trauma. The detailed outcome analysis provided may serve as a reference for future institutional comparisons. | Jake E Krige Eduard Jonas Sandie R Thomson Urda K Kotze Mashiko Setshedi Pradeep H Navsaria Andrew J Nicol | 2017 | World Journal of Gastrointestinal Surgery2017，9，3： | 1 |
| 20 | Atopic and non-atopic asthma in a farming and a general population显示文摘 | Eduard W Omenaas E Bakke PS | 2004 | Am J Ind Med2004，46，4： | 1 |
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