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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Robust power allocation algorithms for MIMO OFDM systems with imperfect CSI显示文摘 | Rey F Lamarca M Vazquez G | 2005 | IEEE Transaction on Signal Processing2005，53，3： | 1 |
| 3 | Hypertensionin Response to Chronic Reductions in Uterine Perfusion in PregnantRats: Effect of Tumor Necrosis Factor-a Blockade 显示文摘 | Babbette LaMarca Josh Speed Lillian Fournier | 2008 | Hypertension2008，52，6： | 1 |
| 4 | Autoantibod-ies to the Angiotensin Type I Receptor in Response to Placental Is-chemia and Tumor Necrosis Factor a in Pregnant Rats 显示文摘 | Babbette LaMarca Gerd Wallukat Mayte Llinas | 2008 | Hyperten-sion2008，52，6： | 1 |
| 5 | Recent progress toward understanding of the pathophysiology of hypertension during preeclampsia 显示文摘 | LaMarca BD Gilbert J Granger JP | 2008 | Hypertension2008，51，4： | 1 |
| 6 | Partial recording protocols for periodontal disease assessment in epidemiological surveys显示文摘 | Vettore MV Lamarca G de A Leao AT | 2007 | Cad Saude Publica2007，23，1： | 1 |
| 7 | Role of endothelin in mediating soluble fms-like tyresine kinase l-induced hypertension in pregnant rats 显示文摘 | Murphy SR LaMarca BB Cockrell K | 2010 | Hypertension2010，55，2： | 1 |
| 8 | Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats显示文摘 | LaMarca BB Cockrell K Sullivan E | 2005 | Hypertension2005，46，： | 1 |
| 9 | Animal model of Gaucher's disease from targeted disruption of the mouse glueoeerebrosidase gene显示文摘 | Tybulewicz V L Tremblay M L LaMarca M E | 2002 | Nature2002，357，6377： | 1 |
| 10 | Leiomyomatosis peritonea- lis disseminata with malignant degeneration: a case report显示文摘 | Lamarca M Rubio P AndrOs P | 2011 | Eur J Gynaecol Oncol2011，32，6： | 1 |
| 11 | Epidermal growth factor-stimulated extravillous cytotrophoblast motility is mediated by the activation of PI3-K, Akt and both p38 and p42/44 mitogen-activated protein kinases 显示文摘 | LaMarca HL Dash PR Vishnuthevan K | 2008 | Hum Reprod2008，23，： | 1 |
| 12 | Pathophysiology of hypertension during preeclampsia:linking placental ischemia with endothelial dysfunction显示文摘 | Gilbert JS Ryan MJ LaMarca BB | 2008 | Am J Physiol Heart Circ Physiol2008，294，2： | 1 |
| 13 | Hypertension produced by reductions in uterine perfusion in the pregnant rat: Role of interleukin-6显示文摘 | Gadonski G LaMarca BB Sullivan E | 2006 | Hypertension2006，48，4： | 1 |
| 14 | Recent progress toward the un- derstanding of the pathophysiology of hypertension during preeclamp- sia显示文摘 | LaMarca BD Gilbert J Granger JP | 2008 | Hypertension2008，51，4： | 1 |
| 15 | Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia显示文摘 | LaMarca BD Ryan MJ Gilbert JS | 2007 | Curr Hypertens Rep2007，9，： | 1 |
| 16 | Three - dimensional growth of extravillous cytotmphoblasts promotes differentiation and invasion显示文摘 | Lamarca HL Ott CM Zu Bentrup K | 2005 | Placenta2005，26，10： | 1 |
| 17 | Angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA)-mediated pregnancy hypertension 显示文摘 | Herse F LaMarca B | 2013 | Am J Reprod Immunol2013，69，4： | 1 |
| 18 | Gaucher disease: mutation and polymorphism spectrum in the glucocerebrosi- dase gene (GBA) 显示文摘 | Hruska KS LaMarca ME Scott CR | 2008 | Hum Murat2008，29，5： | 1 |
| 19 | Role of endothelin in mediating tumor necrosis factor-induced hypertension in pregnant rats 显示文摘 | LaMarca BB Cockrell K Sullivan E | 2005 | Hypertension2005，46，： | 1 |
| 20 | Robust power allocation algorithms for MIMO OFDM systems with imperfect CSI显示文摘 | Rey F Lamarca M Vazquez G | 2005 | IEEE Trans Signal Processing2005，53，3： | 1 |
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