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| 1 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 2 | Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial显示文摘 | Edward B Garon Tudor-Eliade Ciuleanu Oscar Arrieta Kumar Prabhash Konstantinos N Syrigos Tuncay Goksel Keunchil Park Vera Gorbunova Ruben Dario Kowalyszyn Joanna Pikiel Grzegorz Czyzewicz Sergey V Orlov Conrad R Lewanski Michael Thomas Paolo Bidoli Shaker | 2014 | The Lancet2014，，： | 2 |
| 3 | Metabolic response of sheep skin to a chronic infusion of a variant of insulin-like growth factor Ⅰ显示文摘 | Hocking Edwards J E Khalaf S K Sinclaire B R | 1995 | Biochem J1995，308，2： | 1 |
| 4 | Analysis of stained objects in histological sections by spectral imaging and differential absorption显示文摘 | Woemer B M Edwards D A | 1999 | Journal of Histochemistry & Cytochemistry1999，47，10： | 1 |
| 5 | Development and verification of a one-dimensional ablation code including pyrolysis gas flow 显示文摘 | Amar A J Blackwell B F Edwards J R | 2009 | Journal of Thermophysics and Heat Transfer2009，23，1： | 1 |
| 6 | Metagenomic analysis of the microbial community associated with the coral Porites astreoides显示文摘 | Wegley L Edwards R Rodriguez-Brito B | 2007 | Envir Microb2007，9，： | 1 |
| 7 | In silicon predictions of Escherichia coli metabolic capabilities are consistent with experimental data显示文摘 | Edwards J S Ibarra R U Palsson B O | 2001 | Nat Biotechnol2001，19，： | 1 |
| 8 | Consumption of watermelon juice increases plasma concentrations of lycopene and beta- carotene in humans显示文摘 | EDWARDS A J VINYARD B T WILEY E R | 2003 | The Journal of Nutrition2003，133，4： | 1 |
| 9 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 10 | Metage- nomic analysis of the microbial community associated with the coral Porites astreoides显示文摘 | Wegley L Edwards R Rodriguez-Brito B | 2007 | Environmental Microbiology2007，9，11： | 1 |
| 11 | Structural Characterization of the Released Polysaccharide of Desiccation-Tolerant Nostoc commune DRH-1 显示文摘 | Helm R F Huang Z B Edwards D | 2000 | J Bact2000，182，4： | 1 |
| 12 | Using pyrosequencing to shed light on deep mine microbial ecology 显示文摘 | Edwards R A Rodriguez-Brito B Wegley L | 2006 | BMC Genomics2006，7，1： | 1 |
| 13 | Integrating Employment Contracts and Comparisons: What One Can Teach Us About the Other 显示文摘 | O'Neill B S J R B Halbesleben J C Edwards | 2007 | Journal of Managerial Issues2007，，2： | 1 |
| 14 | Graded levels of phytase past industry standards improve broiler performance显示文摘 | SHIRLEY R B EDWARDS H M | 2003 | Poult Sci2003，82，： | 1 |
| 15 | Community genomics among stratified microbial assemblages in the ocean's interior显示文摘 | DeLong E F Preston C M Mincer T Rich V Hallam S J Frigaard N U Martinez A Sullivan M B Edwards R Brito B R Chisholm S W Karl D M | | 0，，5760： | 1 |
| 16 | Inbred-progeny selection is predicted to be inferior to half-sib selection for three maize popu|ations 显示文摘 | Wardyn B M Edwards J W Lamkey K R | 2009 | Crop Science2009，49，2： | 1 |
| 17 | Registry of the International Society for Heart and Lung Transplantation:eleventh official pediatric heart transplantation report-2008显示文摘 | KIRK R EDWARDS L B AURORA P | 2008 | J Heart Lung Transplant2008，27，： | 1 |
| 18 | A Note on the Effect of Farmer Mental Health on Adoption : The Case of Agri - environment Schemes 显示文摘 | Hounsome B Edwards R T Edwards - Jones G | 2006 | Agricultural Systems2006，91，3： | 1 |
| 19 | Independent action and contrasting phenotypes of resistance genes against spotted alfalfa aphid and bluegreen aphid in Medicago truncatula 显示文摘 | Klingler J P Edwards O R Singh K B | 2007 | New Phytologist2007，173，： | 1 |
| 20 | Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA显示文摘 | Leslie A Kavanagh D Honeyborne I Pfafferott K Edwards C Pillay T Hilton L Thobakgale C Ramduth D Draenert R Le Gall S Luzzi G Edwards A Brander C Sewell A K Moore S Mullins J Moore C Mallal S Bhardwaj N Yusim K Phillips R Klenerman P Korber B Kiepiela P Walker B Goulder P | 2005 | J Exp Med2005，201，6： | 1 |
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