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| 1 | Update on cerebral small vessel disease: a dynamic whole-brain disease显示文摘Cerebral small vessel disease(CSVD)is a very common neurological disease in older people.It causes stroke and dementia,mood disturbance and gait problems.Since it is difficult to visualise CSVD pathologies in vivo,the diagnosis of CSVD has relied on imaging findings including white matter hyperintensities,lacunar ischaemic stroke,lacunes,microbleeds,visible perivascular spaces and many haemorrhagic strokes.However,variations in the use of definition and terms of these features have probably caused confusion and difficulties in interpreting results of previous studies.A standardised use of terms should be encouraged in CSVD research.These CSVD features have long been regarded as different lesions,but emerging evidence has indicated that they might share some common intrinsic microvascular pathologies and therefore,owing to its diffuse nature,CSVD should be regarded as a‘whole-brain disease’.Single antiplatelet(for acute lacunar ischaemic stroke)and management of traditional risk factors still remain the most important therapeutic and preventive approach,due to limited understanding of pathophysiology in CSVD.Increasing evidence suggests that new studies should consider drugs that target endothelium and blood–brain barrier to prevent and treat CSVD.Epidemiology of CSVD might differ in Asian compared with Western populations(where most results and guidelines about CSVD and stroke originate),but more community-based data and clear stratification of stroke types are required to address this. | Yulu Shi Joanna M Wardlaw | 2016 | Stroke & Vascular Neurology2016，1，3： | 74 |
| 2 | 压疮的处置显示文摘本“最佳实践信息册”是JBI1997发表的相同主题的最佳实践信息册Ⅲ的更新版,信息基于2005年“英国皇家护理学院”和“英国国家健康和卓越临床研究所”发布的临床实践指南。 | The Joanna Briggs Institute 成磊(译) 胡雁(审校) | 2009 | 中华护理杂志2009，44，6： | 54 |
| 3 | 减少老年人用药差错的策略显示文摘本最佳实践信息册是JBI于2005年发表的相同主题内容的更新[1],资料来自发表于2006-2008年的6篇系统评价[2-7]。在这6篇入选的系统评价中,4篇[2,4-6]报告应用计算机化医嘱输入系统(CPOE)和(或)临床决策支持系统(CDSS),而且没有发现新的证据支持其他类型的干预措施。1篇系统评价报告了可预防的用药不良事件的发生率和特征[3]。因此,大多数先前的最佳实践信息无法得到更新。 | The Joanna Briggs Institute 黄晓燕(译) 胡雁(审校) 薛一帆(审校) | 2010 | 中华护理杂志2010，45，11： | 27 |
| 4 | Response of soil catalase activity to chromium contamination显示文摘The impact of chromium(III) and (VI) forms on soil catalase activity was presented. The Orthic Podzol, Haplic Phaeozem and Mollic Gleysol from different depths were used in the experiment. The soil samples were amended with solution of Cr(III) using CrCl3, and with Cr(VI) using K2Cr2O7 in the concentration range from 0 to 20 mg/kg, whereas the samples without the addition of chromium served as control. Catalase activity was assayed by one of the commonly used spectrophotometric methods. As it was demonstrated in the experiment, both Cr(III) and Cr(VI) have an ability to reduce soil catalase activity. A chromium dosage of 20 mg/kg caused the inhibition of catalase activity and the corresponding contamination levels ranged from 75% to 92% for Cr(III) and 68% to 76% for Cr(VI), with relation to the control. Catalase activity reached maximum in the soil material from surface layers (0–25 cm), typically characterized by the highest content of organic matter creating favorable conditions for microorganisms. | Zofia Stepniewska Agnieszka Wolińska Joanna Ziomek | 2009 | Journal of Environmental Sciences2009，21，8： | 22 |
| 5 | 产妇月子行为和传统习惯及其影响因素显示文摘目的:探讨产妇月子传统习惯及其影响因素。方法:问卷调查与定性研究结合,对本市区产后42天左右的产妇776例问卷调查;定性研究采用半结构性访谈、关键人物访谈及专题小组讨论共调查63人次,其中半结构性访谈有产妇及其家人(丈夫、婆婆或母亲)36人,关键人物访谈有社区产后访视人员4人、中医4人,专题小组讨论有从事或负责社区产后访视工作的护理保健人员及中医19人。结果:776例产妇中,月子期间不洗头洗澡的有54.9%、不刷牙的有36.3%、不吃蔬菜的有19.3%、不吃水果的有36.1%,活动范围只能局限在居室内走动的为100%。主要是长辈的意愿及其传统观念起主导作用;产后访视次数对吃蔬菜的影响有显著性;产妇的文化程度和保健知识掌握程度与月子健康行为呈正相关。结论:从孕期、住院分娩、直至产后1个月内的家庭访视,要不断地向产妇及其婆婆、妈妈、丈夫等负责照顾产妇的家庭成员进行健康宣教,使保健知识不断得到强化,确立并形成产妇坐月子的健康行为,以利母婴身心健康。 | 陈起燕 陈烈平 Joanna Raven 张荣莲 杨闽燕 | 2008 | 中国妇幼保健2008，23，26： | 21 |
| 6 | 渐进式压力长袜预防术后静脉血栓栓塞显示文摘本“最佳实践信息册”是JBI2001发表的相同主题最佳实践信息册的更新版,信息基于2007年出版的由英国国家卫生与临床优化研究所(NICE)委托制作的“静脉血栓栓塞”临床指南。 | The Joanna Briggs Institute 李铮(译) 胡雁(审校) 薛一帆(审校) | 2010 | 中华护理杂志2010，45，5： | 21 |
| 7 | 免疫鸡产生IgY抗体的技术显示文摘IgY技术正在成为生物技术领域和医药研究中的新热点 ,并且越来越得到国内同仁的重视。因为卵黄抗体 (IgY)化学性质稳定 ,产量高、成本低 ,以及动物种系距离的优势 ,更适于生产特异性抗体 ,具有开发功能性食品和新药的潜能。作为系列介绍的第二部分 ,本文详细介绍和探讨免疫鸡产生IgY抗体技术的主要技术环节和实践应用方面的具体信息 ,包括动物饲养 ,对鸡的免疫 ,抗体特性 ,IgY提取技术 ,鸡单克隆抗体的制备等方面。 | 张小莺 郑礼 Rüdiger Schade Horacio Raul Terzolo Hanibal Pablo Chacana Joanna Porankiewicz-Asplund | 2004 | 中国药理学通报2004，20，10： | 19 |
| 8 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 9 | Glutamate transporters in brain ischemia: to modulate or not?显示文摘在这评论,我们简短描述 glutamate (Glu ) 在中央神经系统(CNS ) 的新陈代谢和它的特定的运输和受体。此后,我们集中于有刺激性的氨基酸 transporters, cystine/glutamate antiporters (系统 x c -) 和小囊的 glutamate transporters,明确地在 CNS 和位于 Glu transporters 的规定下面的分子的机制探讨他们的地点和角色。我们响应组织缺氧或局部缺血在 Glu transporter 表示有关改变从在 vitro 或在 vivo 研究提供证据,包括支持在击病人的 Glu transporters 的角色的有限人的数据。而且,通过表示的调整或 Glu transporters 的活动导致大脑忍耐到局部缺血的潜力也被讨论。最后我们包含 ischemic preconditioning 和药理学代理人的申请的现在的策略,例如 β酮抗菌素, amitriptyline, riluzole 和 N-acetylcysteine,它对局部缺血导致紧张的纸巾的重要保护。 | Weronika KRZYZANOWSKA Bartosz POMIERNY Magorzata FILIP Joanna PERA | 2014 | Acta Pharmacologica Sinica2014，，4： | 17 |
| 10 | Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver显示文摘AIM: The expression pattern of endoglin (CD105) in hepatocellular carcinoma (HCC) has not been reported so far. We hypothesized that CD105 could differentially highlight a subset of microvessels in HCC, and intratumoral microvessel density (IMVD) by CD105 immunostaining (IMVD-CD105) could provide better prognostic information than IMVD by CD34 immunostaining (IMVD-CD34).METHODS: Paraffin blocks of tumor and adjacent nontumorous liver tissues from 86 patients who underwent curative resection of HCC were used for this study. Serial sections were stained for CD105 and CD34, respectively,to highlight the microvessels. IMVD was counted according to a standard protocol.RESULTS: In the HCC tissues, CD105 was either negatively or positively stained only in a subset of microvessels. In contrast, CD34 showed positive and more extensive microvessel staining in all cases examined. However, in the adjacent non-tumorous liver sections, CD105 showed a diffuse pattern of microvessel staining in 20 of 86 cases,while CD34 showed negative or only focal staining of the sinusoids around portal area. Correlation with clinicopathological data demonstrated that lower scores of IMVD-CD105 were found in larger sized tumors [mean 41.4/0.74 mm2 (>5 cm tumor) vs 65.9/0.74 mm2(≤ 5 cm tumor), P = 0.043] and more aggressive tumors,as indicated by venous infiltration [36.8/0.74 mm2 (present)vs 64.2/0.74 mm2 (absent), P = 0.020], microsatellite nodules [35.1/0.74 mm2 (present) vs 65.9/0.74 mm2(absent), P = 0.012], and advanced TNM tumor stage [38.8/0.74 mm2 (stage 3 or 4) vs 68.3/0.74 mm2 (stage 1or 2), P = 0.014]. No prognostic significance was observed when median values were used as cut-off points using either IMVD-CD105 or IMVD-CD34. However, the presence of the diffuse pattern of CD105 expression in the adjacent non-tumorous liver tissues predicted a poorer disease-free survival (median 8.6 vs 21.5 mo, P = 0.026).CONCLUSION: Our data demonstrate that a lower IMVDCD105 is associated with larger and more aggressive tumors. In this study, IMVD-CD105 did not provide significant prognostic information. However, active angiogenesis as highlighted by diffuse CD105 staining of the microvessels in the adjacent non-tumorous liver tissues is predictive of early recurrence. | Joanna W.Ho Ronnie T.Poon Chris K.Sun Sheung-Tat Fan | 2005 | World Journal of Gastroenterology2005，11，2： | 16 |
| 11 | Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases显示文摘BACKGROUND: There is a growing evidence that matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinases) play an important role in the pathogenesis of numerous disorders especially with inflammatory etiology and extracellular matrix (ECM) remodeling. Despite the fact that gelatinases involve in liver cirrhosis is provided in the literature, their role in the pathogenesis of chronic pancreatitis and non-specific inflammatory bowel diseases is still under investigation.DATA SOURCES: We carried out a PubM ed search of English language articles relevant to the involvement of gelatinases in the pathogenesis of liver fibrosis, pancreatitis, and non-specific inflammatory bowel diseases.RESULTS: The decreased activity of gelatinases, especially MMP-2, is related to the development of liver fibrosis, probably due to the decrease of capability for ECM remodeling. Similar situation can be found in chronic pancreatitis; however reports on this matter are rare. The presence of non-specific inflammatory bowel diseases results in MMP-9 activity elevation.CONCLUSION: The fluctuation of gelatinases activity during liver fibrosis, chronic pancreatitis and non-specific inflammatorybowel diseases is observed, but the exact role of these enzymes demands further studies. | Jacek Kurzepa Agnieszka M?dro Gra?yna Czechowska Joanna Kurzepa Krzysztof Celiński Weronika Kazmierak Maria S?omka | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 15 |
| 12 | In-vehicle VOCs composition of unconditioned,newly produced cars显示文摘The in-vehicle volatile organic compounds(VOCs) concentrations gains the attention of both car producers and users. In the present study, an attempt was made to determine if analysis of air samples collected from an unconditioned car cabin can be used as a quality control measure. The VOCs composition of in-vehicle air was analyzed by means of active sampling on Carbograph 1TD and Tenax TA sorbents, followed by thermal desorption and simultaneous analysis on flame ionization and mass detector(TD-GC/FID-MS). Nine newly produced cars of the same brand and model were chosen for this study. Within these, four of the vehicles were equipped with identical interior materials and five others differed in terms of upholstery and the presence of a sunroof; one car was convertible. The sampling event took place outside of the car assembly plant and the cars tested left the assembly line no later than 24 hr before the sampling took place. More than 250 compounds were present in the samples collected; the identification of more than 160 was confirmed by comparative mass spectra analysis and 80 were confirmed by both comparison with single/multiple compounds standards and mass spectra analysis. In general, aliphatic hydrocarbons represented more than 60% of the total VOCs(TVOC) determined. Depending on the vehicle, the concentration of aromatic hydrocarbons varied from 12% to 27% of total VOCs. The very short period between car production and sampling of the in-vehicle air permits the assumption that the entire TVOC originates from off-gassing of interior materials. The results of this study expand the knowledge of in-vehicle pollution by presenting information about car cabin air quality immediately after car production. | Krzysztof Brodzik Joanna Faber Damian Lomankiewicz Anna Golda-Kopek | 2014 | Journal of Environmental Sciences2014，26，5： | 14 |
| 13 | 多级孔催化剂的合成及应用(英文)显示文摘系统总结了多级孔分子筛、多级孔金属氧化物和多级孔碳基材料等多级孔催化剂材料的研究进展, 主要阐述了多级孔催化剂材料已有的制备方法及其在催化领域中的应用. | 李小云 孙明慧 ROOKE Joanna Claire 陈丽华 苏宝连 | 2013 | 催化学报2013，34，1： | 12 |
| 14 | Augmenting peripheral nerve regeneration using stem cells: A review of current opinion显示文摘Outcomes following peripheral nerve injury remain frustratingly poor. The reasons for this are multifactorial, although maintaining a growth permissive environment in the distal nerve stump following repair is arguably the most important. The optimal environment for axonal regeneration relies on the synthesis and release of many biochemical mediators that are temporally and spatially regulated with a high level of incompletely understood complexity. The Schwann cell(SC) has emerged as a key player in this process. Prolonged periods of distal nerve stump denervation, characteristic of large gaps and proximal injuries, have been associated with a reduction in SC number and ability to support regenerating axons. Cell based therapy offers a potential therapy for the improvement of outcomes following peripheral nerve reconstruction. Stem cells have the potential to increase the number of SCs and prolong their ability to support regeneration. They may also have the ability to rescue and replenish populations of chromatolytic and apoptotic neurons following axotomy. Finally, they can be used in non-physiologic ways to preserve injured tissues such as denervated muscle while neuronal ingrowth has not yet occurred. Aside from stem cell type, careful consideration must be given to differentiation status, how stem cells are supported following transplantation and how they will be delivered to the site of injury. It is the aim of this article to review current opinions on the strategies of stem cell based therapy for the augmentation of peripheral nerve regeneration. | Neil G Fairbairn Amanda M Meppelink Joanna Ng-Glazier Mark A Randolph Jonathan M Winograd | 2015 | World Journal of Stem Cells2015，7，1： | 12 |
| 15 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 16 | 成人围手术期体温过低的预防和处理策略显示文摘本“最佳实践信息手册”来自Joanna Briggs Institute的一篇系统评价。该系统评价可从JBI循证中心网站(www.joanna briggs.edu.au)获得。 | The Joanna Briggs Institute 吴密彬 胡雁 Yifan ue | 2013 | 中华护理杂志2013，48，9： | 10 |
| 17 | Nitrogen removal from wastewater and bacterial diversity in activated sludge at different COD/N ratios and dissolved oxygen concentrations显示文摘The impact of the organic carbon to nitrogen ratio (chemical oxygen demand (COD)/N) in wastewater and dissolved oxygen (DO) concentration on carbon and nitrogen removal efficiency,and total bacteria and ammonia-oxidizing bacteria (AOB) communities in activated sludge in constantly aerated sequencing batch reactors (SBRs) was determined.At DO of 0.5 and 1.5 mg O2 /L during the aeration phase,the efficiency of ammonia oxidation exceeded 90%,with nitrates as the main product.Nitrification and denitrification achieved under the same operating conditions suggested the simultaneous course of these processes.The most effective nitrogen elimination (above 50%) was obtained at the COD/N ratio of 6.8 and DO of 0.5 mg O2 /L.Total bacterial diversity was similar in all experimental series,however,for both COD/N ratios of 6.8 and 0.7,higher values were observed at DO of 0.5 mg O2 /L.The diversity and abundance of AOB were higher in the reactors with the COD/N ratio of 0.7 in comparison with the reactors with the COD/N of 6.8.For both COD/N ratios applied,the AOB population was not affected by oxygen concentration.Amplicons with sequences indicating membership of the genus Nitrosospira were the determinants of variable technological conditions. | Magdalena Zielińska Katarzyna Bernat Agnieszka Cydzik-Kwiatkowska Joanna Sobolewska Irena Wojnowska-Baryla | 2012 | Journal of Environmental Sciences2012，24，6： | 9 |
| 18 | Synchronous and metachronous neoplasms in gastric cancer patients:A 23-year study显示文摘AIM:To determine the prevalence and characteristics of additional primary malignancies in gastric cancer(GC)patients.METHODS:GC patients(862 total;570 men,292women;mean age 59.8±12.8 years)diagnosed at the Department of Gastroenterology at Pomeranian Medical University over a period of 23 years were included in this retrospective analysis of a prospectively maintained database.Mean follow-up time was 31.3±38.6 mo(range 1-241 mo).The following clinicopathological features of patients with synchronous tumors were compared to those with metachronous tumors:age,sex,symptom duration,family history of cancer,tumor site,stage(early vs advanced),histology,and blood group.GC patients with and without a second tumor were compared in terms of the same clinicopathological features.RESULTS:Of 862 GC patients,58(6.7%)developed a total of 62 multiple primary tumors,of which 39(63%)were metachronous and 23(37%)synchronous.Four(6.9%)of the 58 multiple GC patients developed two or more neoplasms.The predominant tumor type of the secondary neoplasms was colorectal(n=17),followed by lung(n=9),breast(n=8),and prostate(n=7).Age was the only clinicopathological feature that differed between GC patients with synchronous vs metachronous malignancies;GC patients with synchronous neoplasms were older than those with metachronous neoplasms(68.0±10.3 years vs 59.9±11.1years,respectively,P=0.008).Comparisons between patients with and without a second primary cancer revealed that the only statistically significant differences were in age and blood group.The mean age of the patients with multiple GC was higher than that of those without a second primary tumor(63.4±11.4years vs 59.5±13.0 years,respectively,P=0.026).GC patients with a second primary tumor were more commonly blood group O than those without(56.2%vs 31.6%,respectively,P=0.002).CONCLUSION:GC patients may develop other primary cancers;appropriate preoperative and postoperative diagnostic modalities are thus required,particularly if patients are older and blood group O. | Magorzata Lawniczak Alicja Gawin Halina Jaroszewicz-Heigelmann Wiesawa Rogoza-Mateja Joanna Raszeja-Wyszomirska Andrzej Biaek Katarzyna Karpińska-Kaczmarczyk Teresa Starzyńska | 2014 | World Journal of Gastroenterology2014，20，23： | 8 |
| 19 | The effect of mining face's direction on the observed seismic activity显示文摘 | Witold Pytel Joanna Switon Adrian Wojcik | 2016 | International Journal of Coal Science & Technology2016，3，3： | 8 |
| 20 | Intestinal epithelium, intraepithelial lymphocytes and the gut microbiota-Key players in the pathogenesis of celiac disease显示文摘Celiac disease(CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Before activating the immune system, gluten peptides are transferred by the epithelial barrier to the mucosal lamina propria, where they are deamidated by intestinal tissue transglutaminase 2. As a result, they strongly bind to human leucocyte antigens(HLAs), especially HLA-DQ2 and HLA-DQ8, expressed on antigen-presenting cells. This induces an inflammatory response, which results in small bowel enteropathy. Although gluten is the main external trigger activating both innate and adaptive(specific) immunity, its presence in the intestinal lumen does not fully explain CD pathogenesis. It has been hypothesized that an early disruption of the gut barrier in genetically susceptible individuals, which would result in an increased intestinal permeability, could precede the onset of gluten-induced immune events. The intestinal barrier is a complex functional structure, whose functioning is dependent on intestinal microbiotahomeostasis, epithelial layer integrity, and the gutassociated lymphoid tissue with its intraepithelial lymphocytes(IELs). The aim of this paper was to review the current literature and summarize the role of the gut microbiota, epithelial cells and their intercellular junctions, and IELs in CD development. | Bozena Cukrowska Agnieszka Sowińska Joanna Beata Bierla Elzbieta Czarnowska Anna Rybak Urszula Grzybowska-Chlebowczyk | 2017 | World Journal of Gastroenterology2017，23，42： | 7 |
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