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| 1 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 2 | Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-1igase signaling effector DWARF3显示文摘 | Li-Hua Zhao X Edward Zhou Wei Yi Zhongshan Wu Yue Liu Yanyong Kang Li Hou Parker W de Waal Suling Li Yi Jiang Adrian Scaffidi Gavin R Flematti Steven M Smith Vinh Q Lam Patrick R Griffin YonghongWang Jiayang Li Karsten Melcher H Eric Xu | 2015 | Cell Research2015，25，11： | 7 |
| 3 | The structural basis of the dominant negative phenotype of the Gαi1β1Y2 G203A/A326S heterotrimer显示文摘 | Ping LIU Ming-zhu JIA X Edward ZHOU Parker W DE WAAL Bradley M DICKSON Bo LlU Li HOU Yan-ting YIN Ya n-yong KANG Yi SHI Karsten MELCHER H Eric XU Yi JIANG | 2016 | Acta Pharmacologica Sinica2016，37，9： | 3 |
| 4 | Foreign language aptitude and intelligence显示文摘 | Wesche M Edwards H & Wells W | 1982 | Applied Psycholinguistics1982，，3： | 1 |
| 5 | Characterazation of plastein reaction products formed by pepsin, α-chymotrypsin, and papain treat- ment of egg albumin hydrolysates显示文摘 | Edwards J H Shipe W F | 1978 | Food Science1978，43，4： | 1 |
| 6 | OMEGA EP high-energy petawatt laser: progress and prospects显示文摘 | D N Maywar J H Kelly L J Waxer S F B Morse I A Begishev J Bromage C Dorrer J L Edwards L Folnsbee M J Guardalben S D Jacobs R Jungquist T J Kessler R W Kidder B E Kruschwitz S J Loucks J R Marciante R L McCrory D D Meyerhofer A V Okishev J B Oliver G Pien | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 7 | Characterization of plastein reaction products formed by pepsin, α -chymotrypsin, and papain treatment of egg albumin hydrolysates显示文摘 | J H Edwards W F Shipe | 1978 | Journal of Food Science1978，43，： | 1 |
| 8 | Analysis of capacity fade in a lithium ion battery 显示文摘 | ANDREW T S CHARLES E H PALPH E W EDWARD P G | | Journal of Power Sources0，150，4： | 1 |
| 9 | Cloning and characterisation of an oleosin gene from Brassica napus 显示文摘 | W Edwards C H Shaw D J Murphy | 1992 | Plant Molecular Biology1992，19，3： | 1 |
| 10 | Oxygen consumption of river muds 显示文摘 | EDWARDS R W ROLLEY H L J | 1965 | Journal of Ecology1965，53，： | 1 |
| 11 | R trol with conservation tillage and unoff and erosion conreduced-input practices watersheds显示文摘 | Shipitalo M J Edwards W H | 1998 | Soil & Tillage Research1998，46，12： | 1 |
| 12 | Quantitative controls on submarine slope failure morphology显示文摘 | Lee H J Schwab W J and Edwards B D | 1991 | Marine Geotechnology1991，10，： | 1 |
| 13 | Hernia through the foramen of Winslow 显示文摘 | Edwards H Stewart W | 1943 | Br Med J1943，1，4289： | 1 |
| 14 | A biomechanical study of the fatigue characteristics of thorscolumbar fixation implants in a calf spine model显示文摘 | WITTENBERG R H SHEA M EDWARDS W T | 1992 | Spine1992，17，： | 1 |
| 15 | Nosocomial infection rates in adult and pediatric intensive care units in the Unite States显示文摘 | Jarvis W R Edwards J R Culver D H | 1991 | Am J Med1991，91，3： | 1 |
| 16 | Transpiration of well-watered and water stressed Asian Pear Trees as determined by lysimetry, heat-pulse, and estimated by a Penman-Monteith model 显示文摘 | Caspari H W Green S IL Edwards W R N | 1993 | Agricultural and Forest Meteorology1993，，67： | 1 |
| 17 | AusRivAS : Using macro-invertebrates to assess ecological condition of rivers in Western Australia 显示文摘 | Smith M J Kay W R Edward D H D | 1999 | Freshwater Biology1999，41，： | 1 |
| 18 | Runoff and erosion con- trol with conservation tillage and reduced-input practices on cropped watersheds 显示文摘 | Shipitalo M J Edwards W H | 1998 | Soil&Tillage Research1998，46，12： | 1 |
| 19 | AUSRIVAS:using macroinvertenrates to assess ecological condition of rivers in Western Australia显示文摘 | Smith M J Kay W R Edward D H D | 1999 | Fresh Biology1999，，41： | 1 |
| 20 | Practice guideline development task force of the College of American Pathologists : hereditary hemochromatosis 显示文摘 | WITTE D L CROSBY W H EDWARDS C Q | 1996 | Clin Chim Acta1996，245，2： | 1 |
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