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| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Impact of formal training in endoscopic submucosal dissection for early gastrointestinal cancer: A systematic review and a meta-analysis显示文摘AIM: To summarize the clinical impact of a formal training for the effectiveness and safety of endoscopic submucosal dissection for gastrointestinal cancer.METHODS: We searched databases including PubM ed, EMBASE and the Cochrane Library and Science citation Index updated to August 2014 to include eligible articles. In the Meta-analysis, the main outcome measurements were en bloc resection rate, local recurrence rate(R0) and the incidence of procedure-related complications(perforation, bleeding). RESULTS: En bloc resection was high for both, dissecting stomach tumors with an overall percentage of 93.2%(95%CI: 90.5-95.8) and dissecting colorectal tumors with an overall percentage of 89.4%(95%CI: 85.1-93.7). Although the number of studies reporting R0 resection(the dissected specimen was revealed free of tumor in both vertical and lateral margins) was small, the overall estimates for R0 resection were 81.4%(95%CI: 72-90.8) for stomach and 85.9%(95%CI: 77.5-95.5) for colorectal tumors, respectively. The analysis showed that the percentage of immediate perforation and bleeding were very low; 4.96(95%CI: 3.6-6.3) and 1.4%(95%CI: 0.8-1.9) for colorectal tumors and 3.1%(95%CI: 2.0-4.1) and 4.8%(95%CI: 2.8-6.7) for stomach tumors, respectively. CONCLUSION: In order to obtain the same rate of success of the analyzed studies it is a necessity to create training centers in the western countries during the 'several years' of gastroenterology residence first only to teach EGC diagnose and second only to train endoscopic submucosal dissection. | Miguel A Tanimoto M Lourdes Guerrero Yoshinori Morita Jonathan Aguirre-Valadez Elisa Gomez Carlos Moctezuma-Velazquez Jose A Estradas-Trujillo Miguel A Valdovinos Luis F Uscanga Rikiya Fujita | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 2 |
| 4 | 新型雄激素受体种系错义突变与非裔男性家族性前列腺癌显示文摘种族、家族史和年龄是众所周知的前列腺癌危险因素。雄激素受体依赖性信号传送是前列腺癌变和肿瘤转移的重要基础。非裔男性的前列腺癌发病率、死亡率高于白人,且临床恶性程度高。本实验探究了非裔男性家族性前列腺癌与雄激素受体(AR)基因突变之间的关系。实验中我们对参与路易斯安那州立大学健康科学中心前列腺癌遗传连锁研究的30个高危黑人和白人家庭的60名前列腺癌患者的基因组HDNA序列进行了检测。应用外显子特异性聚合酶链反应,双向自动测序和限制性内切酶基因分型分析AR基因编码区突变,结果在一个有早发前列腺癌家族史黑人家庭的3名成员中发现了种系AR-A1675T(T559S)替换突变,突变位于DNA结合区。本研究首次在患家族性前列腺癌的黑人男性中发现了种系雄激素受体突变,该突变可能会改变受体与DNA结合亲和力和/或对雄激素、非雄性类固醇或雄激素拈抗剂的反应。今后的研究应当探索AR(A1675T)序列对黑人早发和/或家族性前列腺癌的影响和影响频率。 | Si-Yi Hu Tao Liu Zhen-Zhen Liu Elisa Ledet Cruz Velasco-Gonzalez Diptasri M Mandal Shahriar Koochekpour | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 5 | Maintenance treatment with Pegylated liposomal doxorubicin versus observation following induction chemotherapy for metastatic breast cancer: GEICAM 2001-01 study显示文摘 | Emilio Alba Manuel Ruiz-Borrego Mireia Margelí álvaro Rodríguez-Lescure Pedro Sánchez-Rovira Amparo Ruiz Jose Ramón Mel-Lorenzo Manuel Ramos-Vázquez Nuria Ribelles Elisa Calvo Antonio Casado Antonia Márquez David Vicente José Angel García-Sáenz Miguel Mar | 2010 | Breast Cancer Research and Treatment2010，，1： | 2 |
| 6 | Isolation and expansion of adult cardiac stem cells from human and murineheart 显示文摘 | Elisa M Lueiana DA Giacome F | 2004 | Circ Res2004，95，8： | 1 |
| 7 | Short- Versus Long-Term Duration of Dual-Antiplatelet Therapy After Coronary Stenting: A Randomized Multicenter Trial显示文摘 | Marco Valgimigli Gianluca Campo Monia Monti Pascal Vranckx Gianfranco Percoco Carlo Tumscitz Fausto Castriota Federico Colombo Matteo Tebaldi Giuseppe Fucà Moh?d Kubbajeh Elisa Cangiano Monica Minarelli Antonella Scalone Caterina Cavazza Alice Frangione M | 2012 | Circulation2012，，16： | 1 |
| 8 | Recent advancements in chemical luminescence-based lab-onchip and microfluidic platforms for bioanalysis显示文摘 | MARA M MASSIMO G ELISA M | 2014 | Journal of Pharmaceutical and Biomedical Analysis2014，87，1： | 1 |
| 9 | Enantioselective ethylation of aldehydes with 1,3-N-donor ligands derived from (+)-camphoric acid显示文摘 | MURTINHO D ELISA S S M ROCHA G | | 0，，： | 1 |
| 10 | Catching up in the global wine industry: innovation systems, cluster knowledge networks and firm-level capabilities in Italy and Chile 显示文摘 | BELL M GUILIANI ELISA | 2007 | International Journal of Technology and Globalisation2007，3，23： | 1 |
| 11 | Role of arginine metabolism in immunity and immune pathology 显示文摘 | ELISA P ILARIA M LUIGI D | 2008 | Immunobiology2008，212，910： | 1 |
| 12 | Overexpression of Osmyb4 enhances compatible solute accumulation and increases stress tolerance of Arabidopsis thaliana 显示文摘 | Monica M Elisa B Roberto C | 2005 | PhysiolPlanta2005，1259，2： | 1 |
| 13 | Cardiomyopathy familial dilated显示文摘 | Matthew RG Elisa C Luisa M | 2006 | Orphanet J of Rare Diseases2006，1，1： | 1 |
| 14 | Optical and structural investigation on rare-earth-doped aluminophosphate glasses显示文摘 | Elisa M Vasiliu I C Cristiana E A | 2006 | Optical Materials2006，28，： | 1 |
| 15 | Sol-gel combustion synthesis of BNBT powders显示文摘 | Elisa M Carmen G Anna L C | 2008 | Journal of Sol-Gel Science and Technology2008，46，： | 1 |
| 16 | Reproducibility and validity of a food-frequency questionnaire for use among low-income Brazilian workers显示文摘 | Fonres N S Stringhini M L Elisa B M | 2003 | Public Health Nutirtion2003，6，： | 1 |
| 17 | Isolation and expansion of adult cardiac stem cells from human and murine heart显示文摘 | Elisa M Luciana D Giacomo F | 2004 | Circ Res2004，95，： | 1 |
| 18 | Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene☆显示文摘 | Victor R Gordeuk Angela Caleffi Elena Corradini Francesca Ferrara Russell A Jones Oswaldo Castro Onyinye Onyekwere Rick Kittles Elisa Pignatti Giuliana Montosi Cinzia Garuti Innocent T Gangaidzo Z.A.R Gomo Victor M Moyo Tracey A Rouault Patrick MacPhail A | 2003 | Blood Cells Molecules and Diseases2003，，3： | 1 |
| 19 | Selective chemical oxidation or reduction of chlorophenols with potassium nitro-sodisulfonate显示文摘 | Elisa L Ismael C Edgar M | 2003 | Organic Chemistry in Mexico2003，7，： | 1 |
| 20 | A matching algorithm for measuring the structural similarity between an XML document and a DTD and its applications 显示文摘 | Elisa B Giovanna G Macro M | 2004 | Information Systems2004，29，： | 1 |
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