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| 1 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Must treatments and wild yeastgrowth before and during alcoholic fermentation 显示文摘 | Agostino C Elisa P Raffaele G | 2011 | Ann Micro-biol2011，，6： | 1 |
| 4 | Biological effects of 6 mT static magnetic fields: A comparative study in different cell types 显示文摘 | Bernadette T Alfonsina C Elisa P | 2006 | Bioelectromagnetics2006，27，7： | 1 |
| 5 | Mental Workload and Visual Impairment: Differences be- tween Pupil, Blink, and Subjective Rating 显示文摘 | Miguel A R Elisa P Angela C | 2008 | The Spanish Journal of Psychology2008，11，2： | 1 |
| 6 | Role of arginine metabolism in immunity and immune pathology 显示文摘 | ELISA P ILARIA M LUIGI D | 2008 | Immunobiology2008，212，910： | 1 |
| 7 | Clay minerals for adsorption of veterinary FQs: Behavior and modeling 显示文摘 | ELISA R ANNA P MICHELA S | 2014 | Journal of Environmental Chemical Engineering2014，2，1： | 1 |
| 8 | Alpha 1 antichymotryp- sin genotype is associated with increased risk of prostate carcinoma and PSA levels显示文摘 | Federico L Alessandro B Elisa P | 2008 | Anticancer Res2008，28，1： | 1 |
| 9 | Combined 3 D visualization of volume data and polygonal models using a Shear-Warp algorithm显示文摘 | Schmidt Ana Elisa F Gattass Marcelo Carvalho Paulo Cezar P | 2000 | Computers & Graphics2000，24，4： | 1 |
| 10 | Electrodeposition of Co-Ni and Co-Ni-Cu systems in sulphate-citrate medi- um 显示文摘 | Elvira G Salvador P Elisa V | 2005 | Electrochim Acta2005，51，： | 1 |
| 11 | Sequential toxicity idenitrification evaluation(TIE) for characterizing toxicity of Venice Lagoon sediments:Comparison of two different approaches显示文摘 | Marco P A Martina B Elisa V | 2009 | Ecotoxicology and Environmental Safety2009，72，： | 1 |
| 12 | A multi-analytical study on thephotochemical degradation of synthetic organic pigments显示文摘 | Elisa G Ilaria D Maria P C | 2015 | Dyesand Pigments2015，123，39： | 1 |
| 13 | Flavonoids as antioxidants in plants: location and functional significance显示文摘 | GIOVANNI A ELISA A SUSANNA P | 2012 | Plant Sei2012，196，： | 1 |
| 14 | Including technical and security risks in the management of information systems:a programmatic risk management model显示文摘 | Robin L Dillon M Elisa beth P | 2005 | Systems Engineering2005，8，4： | 1 |
| 15 | Effects of long-term heavy metal contamination on soil microbial characteristics显示文摘 | ADILIA O MARIA ELISA P | 2006 | Journal of Bioscience and Bioengineering2006，102，3： | 1 |
| 16 | Improved RNA extraction and one-tube RT-PCR assay simultaneous detection of control plant RNA plus several viruses in plant extracts显示文摘 | Elisa P Katherine Helmeczy | 2000 | Journal of Virological Methodes2000，90，： | 1 |
| 17 | Micellar liquid chromatography determination of B vitamins with direct injection and ultraviolet absorbance detection显示文摘 | LORENC M P ELISA C P MAYTE G A | 2003 | J Chromatogr: A2003，984，： | 1 |
| 18 | Improved RNA extrac- tion and one-tube RT-PCR assay for simultaneous detec- tion of control plant RNA plus several viruses in plant extracts 显示文摘 | Annette N Elisa P Katherine H | 2000 | Journal of Virological Methods2000，90，1： | 1 |
| 19 | Trichocystatin-2 (TC-2):An en- dogenous inhibitor of cysteine proteinases in Trichomonas vaginalis is associat- ed with TvCP39显示文摘 | Jonathan P Lucero A Elisa E F | 2014 | The International Journal of Biochemistry & Cell Biology2014，54，： | 1 |
| 20 | TRBAC : a temporal role-based access control model 显示文摘 | ELISA B ANDREA B P ELENA F | 2000 | ACM Trans on Information and Systems Security2000，4，3： | 1 |
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