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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Ecological of the rare microbial biosphere of the Arctic Ocean 显示文摘 | Pierre E G Emilio O C David L K | 2009 | PNAS2009，106，22： | 1 |
| 3 | Hy- bridizing the fifth generation mesoscale model with arti- ficial neural networks for short-term wind speed predic- tion显示文摘 | SANCHO S S ANGEL M P A EMILIO G O | 2009 | Renewable Energy2009，34，： | 1 |
| 4 | Ecological of the rare microbial biosphere of the Arctic Ocean显示文摘 | Pierre E G Emilio O C David L K | 2009 | PNAS2009，106，22： | 1 |
| 5 | Short term wind speed prediction based on evolutionary support vector regres- sion algorithms显示文摘 | Sancho S S Emilio G O Angel M | 2011 | Expert Systems with Applications2011，38，4： | 1 |
| 6 | An Easy Demonstration of the Optimum Value of the Adaptation Constant in the LMS Algorithm显示文摘 | Emilio S O Javier C M Juan F G | 1998 | IEEE Transactions on Education1998，41，1： | 1 |
| 7 | Short term wind speed prediction based on evolutionary support vector regression algorithms 显示文摘 | SANCHO S S EMILIO G O | 2011 | Expert Systems with Applications2011，38，4： | 1 |
| 8 | BELM: Bayesian Extreme Learning Machine显示文摘 | Emilio S O Juan G S Martín J D | 2011 | IEEE Transactions on Neural Networks2011，22，3： | 1 |
| 9 | Upregulation of Trefoil Factor 3 (TFF3) After Rectal Cancer Chemoradiotherapy Is an Adverse Prognostic Factor and a Potential Therapeutic Target显示文摘 | Enrique Casado Victor Moreno Garcia Jose Javier Sánchez María Teresa Gómez del Pulgar Jaime Feliu Joan Maurel Beatriz Castelo Juan Moreno Rubio Rocío A.B. López Miguel ángel García-Cabezas Emilio Burgos Javier de Castro Cristóbal Belda-Iniesta Miriam Lópe | 2012 | International Journal of Radiation Oncology, Biology, Physics2012，，5： | 1 |
| 10 | BELM: Bayesian extreme learning machine显示文摘 | EMILIO S O JUAN G S | 2011 | IEEE Transactions on Neural Networks2011，22，3： | 1 |
| 11 | A new La2/3LixTi1_xAlxO3 solid solution: Structure, Microstructure, and Li+ conductivity显示文摘 | AINHOA M O SUSANA G M EMILIO M | 2002 | Chemical Materials2002，14，： | 1 |
| 12 | Oxygen uptake rate in microbial processes:An overview显示文摘 | Felix G O Emilio G Victoria E S | 2010 | Biochem Eng J2010，49，： | 1 |
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