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| 1 | Beneficial mechanisms of aerobic exercise on hepatic lipid metabolism in non-alcoholic fatty liver disease显示文摘BACKGROUND:Non-alcoholic fatty liver disease(NAFLD)refers to any fatty liver disease that is not due to excessive use of alcohol.NAFLD probably results from abnormal hepatic lipid metabolism and insulin resistance.Aerobic exercise is shown to improve NAFLD.This review aimed to evaluate the molecular mechanisms involved in the beneficial effects of aerobic exercise on NAFLD.DATA SOURCE:We searched articles in English on the role of aerobic exercise in NAFLD therapy in Pub Med. | Rui Guo Emily C Liong Kwok Fai So Man-Lung Fung George L Tipoe | 2015 | Hepatobiliary & Pancreatic Diseases International2015，14，2： | 16 |
| 2 | Therapeutic approaches to non-alcoholic fatty liver disease: past achievements and future challenges显示文摘BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver injury and mortality in Western countries and China. However, as to date, there is no direct and effective therapy for this disease. The aim of this review is to analyze the key progress and challenges of main current therapeutic approaches in NAFLD. DATA SOURCE: We carried out a PubMed search of English-language articles relevant to NAFLD therapy. RESULTS: There are two major therapeutic strategies for NAFLD treatment: (1) lifestyle interventions (including weight reduction, dietary modification and physical exercise) and (2) pharmaceutical therapies. Lifestyle interventions, particularly chronic and moderate intensity exercise, are the most effective and recognized clinical therapies for NAFLD. For pharmaceutical therapies, although their effects and mechanisms have been extensively investigated in laboratory studies, they still need further tests and investigations in clinical human trials. CONCLUSION: Future advancement of NAFLD therapy should focus on the mechanistic studies on cell based and animal models and human clinical trials of exercise, as well as the combination of lifestyle intervention and pharmaceutical therapy specifically targeting main signaling pathways related to lipid metabolism, oxidative stress and inflammation. | Jia Xiao Rui Guo Man Lung Fung Emily C Liong George L Tipoe | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 14 |
| 3 | Pneumocystis jirovecii pneumonia显示文摘 | Emilie C Fanny L Marie EB | 2010 | Infect Dis Clin N Am2010，24，10： | 1 |
| 4 | Self-eare and qual- ity of life of heart failure patients at a multidisciplinary heart function clinic显示文摘 | Emily S Kevin J L Joseph A C | 2011 | J Cardiovase Nuts2011，26，5： | 1 |
| 5 | Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer显示文摘 | Greenspan Emily J Cyr Jennifer L Pleau Devon C | 2007 | Carcinogenesis2007，28，4： | 1 |
| 6 | A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis显示文摘 | Stephen H Caldwell Elizabeth E Hespenheide Jan A Redick Julia C Iezzoni Emily H Battle Bonnie L Sheppard | 2001 | The American Journal of Gastroenterology2001，，2： | 1 |
| 7 | Antimi- crobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia 显示文摘 | Lai Wah Chan Emily L C Cheah Constance L L Saw | 2008 | Chin Med J2008，，3： | 1 |
| 8 | Self-esteem and coping strategies in child molesters显示文摘 | Marshall W L Emily C Anderson D | | Journal of Interpersonal Violence0，，9： | 1 |
| 9 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 10 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
| 11 | Circulating [alpha]Klotho influences phosphate handling by controlling FGF23 production显示文摘 | Smith Rosamund C O’Bryan Linda M Farrow Emily G Summers Lelia J Clinkenbeard Erica L Roberts Jessica L Cass Taryn A Saha Joy Broderick Carol Ma Y Linda Zeng Qing Qiang Kharitonenkov Alexei Wilson Jonathan M Guo Qianxu Sun Haijun Allen Matt | 2012 | Journal of Clinical Investigation2012，，12： | 1 |
| 12 | Bisphenol A is Re- leased from Polycarbonate Drinking Bottles and Mimics the Neurotoxic Actions of Estrogen in Developing Cerebellar Neu- rons显示文摘 | HOA H L EMILY M C JASON P C | 2008 | Toxicology Letters2008，176，2： | 1 |
| 13 | Comparing forest assessment based on computer visualization versus videography 显示文摘 | Ikuko Fujisaki Mahnas Jean Mohammadi-Aragb David L Evans Robert J Moorhead Derek W Irby Scott D Roberts Stephen C G-rado Emily B Schultz | | Landscape and Urban0，，： | 1 |
| 14 | Optimization of supercritical fluid extraction and pressurized liquid extraction of active principles from Magnolia of ficinalis using the Taguchi design显示文摘 | EMILY L C CHEAH W S LAI W C | 2010 | Separation and Purification Technology2010，71，4： | 1 |
| 15 | Parameters governing gold nanoparticle X-ray radiosensitization of DNA in solution显示文摘 | Emilie Brun Léon Sanche Cécile Sicard-Roselli | 2009 | Colloids and Surfaces B: Biointerfaces2009，，1： | 1 |
| 16 | Canine parvovirus types 2c and 2b circulating in North American dogs in 2006 and 2007显示文摘 | Sanjay K Emily C Cathy L | 2007 | J Clin Microblol2007，45，12： | 1 |
| 17 | The Correspon-dent,the Comic,and the Combatant:The Consequence of Host Style in Political Talk Shows显示文摘 | Emily K. V Stephanie E L Bode D.Jasun C Mitchell B C.N.Johnson Y.M Kim and Dhavan V.Shah | | 0，，： | 1 |
| 18 | Bis- phenol A is Released from Polycarbonate Drinking Bottles and Mimics the Neurotoxic Actions of Estro- gen in Developing Cerebellar Neurons 显示文摘 | HOA H L EMILY M C JASON P C etal | 2008 | Toxicol Lett2008，176，： | 1 |
| 19 | En- hanced bioproduction of carvone in a two-liquid-phase partitioning bioreactor with a highly hydrophobic bio- catalyst 显示文摘 | Jenna L E M Emily T B Helen C D | 2008 | Biotechnol Bioeng2008，101，4： | 1 |
| 20 | 儿童期哮喘病史与青年期无症状动脉硬化的关系:Bogalusa心脏研究显示文摘哮喘与各种心血管病风险相关。目前尚不清楚儿童期哮喘病史是否会导致成年动脉硬化(心血管事件的一种无创性替代指标)。为此,Dianjianyi对年龄20~51岁有儿童期哮喘病史的Bogalusa心脏研究参与者1746人进行前瞻性分析。 | 刘青 叶鹏 Dianjianyi S Xiang L Yoriko H Hoirun N Xiaoyun S Felicia R Tanika K Emily H Shengxu L Jiang H Lydia B Wei C Lu Q | 2018 | 中华高血压杂志2018，26，6： | 0 |
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