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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression显示文摘 | Endres M Fan G Hirt L | 2000 | J Cereb Blood Flow Metab2000，20，1： | 2 |
| 3 | Stroke damage in mice after knocking the neutrophin-4 gene into the brain-derived neurotrophic factor locus 显示文摘 | Endres M Fan G Hirt L | 2003 | J Cereb Blood Flow Metab2003，23，2： | 1 |
| 4 | Post-stroke depression:Clinical aspects,epidemiology,therapy and pathophysiology显示文摘 | Kronenberg G Katchanov J Endres M | 2006 | Nervenarzt2006，77，9： | 1 |
| 5 | Post-stroke depression:mechanisms,translation and therapy显示文摘 | Loubinoux I Kronenberg G Endres M | 2012 | J Cell Mol Med2012，16，9： | 1 |
| 6 | Comparison of three strategies to delineate the bowel for whole pelvis IMRT of prostate cancer显示文摘 | anguineti G Little M Endres | 2008 | Radiother Oncol2008，88，1： | 1 |
| 7 | lschemic brain damage inmice after selectivelymodify-ing BDNF orNT gene expression显示文摘 | Endres M Fan G Hirt L | 2000 | Cereb Blood FlowMetab2000，20，1： | 1 |
| 8 | Cell survival or death in renal tubularepithelium after ischemia-repeffusion injury 显示文摘 | Gobe G WiUgoss D Hogg N Schoch E Endre Z | 1999 | Kidney Int1999，56，4： | 1 |
| 9 | Post-stroke depression: me chanisms, translation and therapy显示文摘 | Loubinoux I Kronenberg G Endres M | 2012 | Journal of Cellular and Molecular Medicine2012，16，9： | 1 |
| 10 | Acute toxicity of whole-pelvis IMRT in 87 patients with localized prostate cancer 显示文摘 | Sanguineti G Endres EJ Parker BC | 2008 | Acta 0ncol2008，47，： | 1 |
| 11 | Post stroke depression: mechanisms, translation and therapy 显示文摘 | Loubinoux I Kronenberg G Endres M | 2012 | J Cell Mol Med2012，16，9： | 1 |
| 12 | Folic acid, neurodeg- enerative and neuropsychiatric disease显示文摘 | Kronenberg G Colla M Endres M | 2009 | CurrMe/Med2009，9，： | 1 |
| 13 | A receptor kinase regulating symbiotic nodule development显示文摘 | Endre G Kereszt A Kevei Z | 2002 | Nature2002，417，： | 1 |
| 14 | Post-stroke depres- sion : Clinical aspects, epidemiology, therapy and pathophysi- ology 显示文摘 | Kronenberg G Katehanov J Endres M | 2006 | Nerve-narzt2006，77，1： | 1 |
| 15 | Post-stroke depression: clinical aspects, epidemiology, therapy, and pathophysiology 显示文摘 | Kronenbeereg G Katchanov J Endres M | 2006 | Nervenarzt2006，10，77： | 1 |
| 16 | Theeffecl of lime to surgery on outcome in elderly patients with proximal femoral fractures显示文摘 | SmektalaR Endres H G DaschB ecal | 2008 | BMC MuscuLoskeletal Disorders2008，29，9： | 1 |
| 17 | High resolution sediment and vegetation responses to Younger Dryas climate change in varved lake sediments from Meerfelder Maar,Germany显示文摘 | Brauer A Endres C G nter C Litt T Stebich M Negendank J F W | | 0，，： | 1 |
| 18 | Inhibition of Toll-like receptor 7- and 9- mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus 显示文摘 | Schlender J Hornung V Finke S Gfinthner-Biller M Marozin S Brz6zka K Moghim S Endres S Hartmann G Conzelmann KK | 2005 | J Virol2005，79，9： | 1 |
| 19 | Poststroke depres- sion : mechanisms, translation and therapy 显示文摘 | Loubinoux I Kronenberg G Endres M | 2012 | J Cell Mol Med2012，16，： | 1 |
| 20 | Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit显示文摘 | Westhuyzen J Endre ZH Reece G | 2003 | Nephrol Dial Transplant2003，18，： | 1 |
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