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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Individual fluorouracil dose adjustment based on pharmacokinetic follow - up compared with conventional dosage : results of a muhicenter randomized trial of patients with metastatic colorectal cancer 显示文摘 | ERICK G REMY D JACQUES J | 2008 | J Clin Oncol2008，26，13： | 1 |
| 3 | Eocene and Oligocene paleosols of Central Oregon显示文摘 | Retallack Gregory John Bestland Erick A Fremd Theodore J | | 0，，： | 1 |
| 4 | The current sta-tus of camptothecin analogues as antitumor asents显示文摘 | Erick Rowinsky Ross O D illjam J Slichenmyer | 1983 | WJ the Natl cancer Institue1983，85，4： | 1 |
| 5 | Earlyhemonhage growth in patients with intrac erebral hemorrhage显示文摘 | Brott T Brod erick J Kothari R | 1997 | Siroke1997，28，1： | 1 |
| 6 | Co-teaching is a science methods course, a situated learning model of being a teacher 显示文摘 | Erick C J F N Ware P G Williams | 2003 | Journal of Teaches Education2003，，54： | 1 |
| 7 | Polymor-phism and partial characterization of digestive enzymesin the spiny lobster Panulirus argus显示文摘 | Erick Perera Moyano F J Díaz M | 2008 | ComparativeBiochemistry and Physiology Part B2008，150，3： | 1 |
| 8 | Microbial sucrose phosphorylase:fermentation process,properties,and biotechnical applications显示文摘 | Erick J Vandamme Jan Van Loo Lieve M | 1987 | Advances in Applied Microbiology1987，32，6： | 1 |
| 9 | Effects of leuprolide-induced hypogonadism and testosterone replacement on sleep,melatonin,and prolacfin secretion in men显示文摘 | Peter J S Erick H T | 1997 | J Clin Endocrinol Metab1997，82，10： | 1 |
| 10 | The role of phytosterols in plantadaptation to temperature显示文摘 | ERICK J DUFOURC W | 2008 | Signaling&Behavior2008，3，2： | 1 |
| 11 | Cyclin-dependent kinase and P53 pathways are activated independently and mediate Bax activation in neurons after DNA damage显示文摘 | Erick J Elizabeth K Hardy J | 2001 | J Neurosci2001，21，14： | 1 |
| 12 | The current status of camptothecin analogues as antitumor agents 显示文摘 | Erick Rowinsky Ross 0 D illiam J Slichenmyer | 1983 | WJ the Natl cancer Institue1983，85，4： | 1 |
| 13 | Vandamme, Influence of the phosphorus and nitrogen source on nisin production in Lactocoecus lactis subsp,lactis batch fermentations using a complex medium显示文摘 | Luc De Vuyst Erick J | 1993 | Appl Microbiol Biotechnol1993，40，： | 1 |
| 14 | Induction of Neuronal Apoptosis by Camptothecin, An Inhibitor of DNA Topoisomerase-I: Evidence for Cell Cycle-inde- pendent Toxicity显示文摘 | Erick J Morris and Herbert M GeUer | 1996 | The Journal of Cell Biology1996，6，12： | 1 |
| 15 | Does high nitrogen loading prevent clear-water conditions in shallow lakes at moderately high phosphorus concentrations? 显示文摘 | Maria A Gonzo' Lez S Erick J | 2004 | Freshwater Biology2004，27，2： | 1 |
| 16 | Individual fluorouracil dose adjustment based on pharmacokinetic follow-up compared with conventional dosage:results of a nmlticenter randomized trial of patients with metastatic colorectal cancer 显示文摘 | Erick G Remy D Jacques J et at | 2008 | J Clin Oncol2008，26，28： | 1 |
| 17 | Experimental comparison study of control architectures for bilateral teleoperators显示文摘 | ERICK J RODRIGUEZ-SEDA M W S DONGJUN L | | 0，，6： | 1 |
| 18 | On the classification of stationary sets显示文摘 | Erick Van Douwen David J Lutzer | 1979 | in: Michigan Math J1979，26，： | 1 |
| 19 | Estrogen recep to r gene expression in human uterine leiomyomata显示文摘 | Brandon D D Erick son T E Keenan E J | 1995 | J Clin Endocrino IM1995，80，6： | 1 |
| 20 | Are Family Firms Born or Made? An Exploraiory Investigation显示文摘 | Jess H Chua James J Chrisman Erick PC Chang | 2004 | Family Business Review2004，3，： | 1 |
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