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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y | 1998 | Science1998，280，： | 1 |
| 3 | A group-IV ferromagnetic semiconductor : Mnx Ge1-x 显示文摘 | PARK Y D HANBICKI A T ERWIN S C | 2002 | Science2002，295，5555： | 1 |
| 4 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 5 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 6 | U/Pb zircon geochronology and tempo of the End-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 7 | U/Pb zircon geochro- nology and tempo of the end-Permian mass extinction显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Sci- ence1998，280，： | 1 |
| 8 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 9 | Specific properties and fracture toughness of syntactic foam: Effect of foam microstructures 显示文摘 | Erwin M Wouterson Freddy Y C Boey Xiao Hua | 2005 | Composites Science and Technology2005，65，： | 1 |
| 10 | Estradiol-treated mesenchymal stem cells improve myocardial recovery after ischemia 显示文摘 | Erwin GS Crisostomo PR Wang Y | 2009 | J Surg Res2009，152，： | 1 |
| 11 | Development of a highly sensitive inhibition immunoassay for microcystin-LR显示文摘 | PETRA L RAMONA M ERWIN Y | 2004 | Anal Chim Acta2004，521，： | 1 |
| 12 | Observation of second-phase particles in bulk zirconium alloys using synchrotron radiation显示文摘 | ERWIN K T DELAIRE O MOTTA A T CHU Y S MANCINI D C BIRTCHER R C | 2001 | J Nucl Mater2001，294，： | 1 |
| 13 | Development of a highly sensitive inhibition immunoassay for microcystin-LR显示文摘 | Petra L Ramona M Erwin Y G | 2004 | Anal Chim Acta2004，521，1： | 1 |
| 14 | U/Ph zircon geochronology and Tempo of the end-Permian mass extinction显示文摘 | Bowring S A Erwin D H Jin Y G | 1988 | Science1988，280，15： | 1 |
| 15 | A group-IV ferromagnetic semiconductor:MnxGe1x显示文摘 | Hanbicki A T Erwin S C | 2002 | Science2002，295，： | 1 |
| 16 | U/Pb zircon geochronology and tempo of the end-Permian mass extinction显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
| 17 | A Group-IV Ferromagnetic Semiconductor:MnxGe1-x显示文摘 | Park Y D Hanbicki A T Erwin S C Hellberg C S Sullivan J M Mattson J E Ambrose T F Wilson A Spanos G Jonker B T | 2002 | Science2002，295，： | 1 |
| 18 | A group-IV fer- romagnetic semiconductor: Mnx Gel-x 显示文摘 | Park Y D Hanbicki A T Erwin S C | 2002 | Science2002，295，： | 1 |
| 19 | Serological Evidence for the Association of Bartonella henselae Infection with Arrhythmogenic Right Ventricular Cardiomyopathy显示文摘 | AndreasH. Fischer Berndvan der Loo GertrudM. Sh?r ReinhardZbinden FiratDuru CorinnaBrunckhorst ValentinRousson EtienneDelacrétaz y ThomasStuber Erwin N.Oechslin FerencFollath RolfJenni | 2008 | Clin Cardiol2008，，10： | 1 |
| 20 | U/Pb zircon geo- chronology and tempo of the end-Permian mass extinction 显示文摘 | Bowring S A Erwin D H Jin Y G | 1998 | Science1998，280，： | 1 |
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