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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest显示文摘在干旱的热带森林中,草本植物可能具有休眠机制,并在土壤中形成持续和短暂的种子库。这一由进化而获得的机制对草本植物的建植和生存,特别是在气候不可预测的森林生态系统中,具有重要生态适应意义。因此,本研究的目的是验证草本植物是否具备物理休眠机制,以及这些植物是如何克服这些自然屏障的,并最终理解巴西干旱热带森林土壤种子库中种子萌发时间动态。本研究选择巴西Caatinga森林中的5种本地草本植物的种子,经过发芽前处理来验证是否存在物理休眠。连续4年在雨季和旱季收集土壤样品,并监测这些草本植物种子在温室中的萌发动态。利用广义线性模型验证种子萌发和出苗率的差异。研究结果表明Caatinga森林中的草本植物种子存在着物理休眠和非物理休眠;而且草本植物从土壤种子库中出苗的种内和种间存在着年份和季节的差异。对于多年生草本植物,不同季节和年份频繁出现不出苗的现象,这可能与物理休眠机制和克服种皮障碍所需的环境条件有关。在这些物种中,种子的二态性和休眠可能给它们的生存带来额外的优势。此外,在一年生植物中出现中等水平的物理休眠可能是对降雨不可预测性的进化调整。相比之下,我们发现没有休眠的一年生草本植物对季节和年际气候变化更敏感,这可以从土壤种子库中其出苗率的增加和显著减少得到证明。这些通过进化获得的种子休眠差异有利于那些分布在气候变化无常的半干旱地区草本植物种群的建立。 | José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de Andrade Elcida de Lima Araújo | 2020 | Journal of Plant Ecology2020，13，3： | 1 |
| 3 | Phytochemical study guided by the myorelaxant activity of the crude extract, fractions and constituent from stem bark of Hymenaea courbaril L.显示文摘 | Gabrieli Penha Bezerra Roberto Wagner da Silva Góis Teresinha Silva de Brito Francisco José Batista de Lima Mary Anne Medeiros Bandeira Nirla Rodrigues Romero Pedro Jorge Caldas Magalh?es Gilvandete Maria Pinheiro Santiago | 2013 | Journal of Ethnopharmacology2013，，： | 1 |
| 4 | Assessing arsenic, cadmium, and lead contents in major crops in Brazil for food safety purposes显示文摘 | Ana Paula Branco Corguinha Guilherme Amaral de Souza Veridiana Cardoso Gon?alves Camila de Andrade Carvalho Willian Eduardo Amaral de Lima Fábio Aurélio Dias Martins Celso Hideto Yamanaka Eros Artur Bohac Francisco Luiz Roberto Guimar?es Guilherme | 2014 | Journal of Food Composition and Analysis2014，，： | 1 |
| 5 | Determination of arsenic compounds in beverages by high - performance liquid chromatography - inductively coupled plasma mass spectrometry 显示文摘 | NMM Coelho LN Coelho ES de Lima | 2005 | Talanta2005，66，： | 1 |
| 6 | Effect of Estrogen–Progestogen Hormonal Replacement Therapy on Periurethral and Bladder Vessels显示文摘 | R. M. Endo M. J. B. C. Gir?o M. G. F. Sartori M. J. Sim?es E. C. Baracat G. Rodrigues de Lima | 2000 | International Urogynecology Journal2000，，2： | 1 |
| 7 | Experimental evaluation of extended endplate beam-to-column joints subjected to bending and axial force显示文摘 | L.R.O. de Lima L. Sim?es da Silva P.C.G.da S. Vellasco S.A.L. de Andrade | 2004 | Engineering Structures2004，，10： | 1 |
| 8 | Experimental evaluation of extended endplate beam-to-column joints subjected to bending and axial force显示文摘 | L.R.O. de Lima L. Sim?es da Silva P.C.G.da S. Vellasco S.A.L. de Andrade | 2004 | Engineering Structures2004，，10： | 1 |
| 9 | Uterine volume and menstrual patterns in users of the levonorgestrel-releasing intrauterine system with idiopathic menorrhagia or menorrhagia due to leiomyomas B显示文摘 | Magalhes J Aldrighi JM de Lima GR | 2007 | Contraception2007，75，3： | 1 |
| 10 | Maxillary canine retraction with self-ligating and conventional brackets显示文摘 | Mezomo M de Lima ES de Menezes LM | 2011 | Angle Orthod2011，81，2： | 1 |
| 11 | Maxillary canine retraction with self-ligating and conventional brackets 显示文摘 | Mezomo M de Lima ES de Menezes LM Weissheimer A Allgayer S | 2011 | Angle Orthod2011，8，2： | 1 |
| 12 | Maxillary canineretraction with self-ligating and conventional brackets显示文摘 | Mezomo M de Lima ES de Menezes LM | 2011 | AngleOrthod2011，81，2： | 1 |
| 13 | Behaviour of flush end-plate beam-to-column joints under bending and axial force 显示文摘 | Luís Sim?es da Silva L R O de Lima P C G das Vellasco S A L de Andrade | 2004 | Steel and Composite Structures2004，4，2： | 1 |
| 14 | Maxillary canine retraction with self-ligating and conventional brackets 显示文摘 | Mezomo M de Lima ES de Menezes LW | 2011 | Angle Orthod2011，81，2： | 1 |
| 15 | Mechanical reduction of the bacterial population in the root canal by three instrumentation techniques显示文摘 | José F. Siqueira Kenio C. Lima Fernando A.C. Magalh?es Hélio P. Lopes Milton de Uzeda | 1999 | Journal of Endodontics1999，，5： | 1 |
| 16 | Preliminary stages before nasal reconstruction using forehead flap:restoring perinasal subunits and nostril patency显示文摘Due to the complex three-dimensional structure of the nose,the repair of the nasal defect requires reconstruction of three different layers:skin envelope,osteocartilaginous framework and nasal lining.Before nasal reconstruction can be accomplished,the nose must rest on a stable platform to avoid late nasal obstructions,and septal deviations resulting from scar contraction.We present three cases of nasal reconstruction using a forehead flap in which we performed a preliminary stage to increase reliability of outcomes. | Victor Diniz de Pochat Fernando César Câmara de Oliveira Felipe Simões da Rocha Mata Marcelo Sacramento Cunha Nivaldo Alonso JoséValber Lima Meneses | 2015 | Plastic and Aesthetic Research2015，2，1： | 0 |
| 17 | Preemptive endoluminal vacuum therapy after pancreaticoduodenectomy: A case report显示文摘BACKGROUND Pancreaticoduodenectomy is a technically demanding operation,with reported morbidity rates of approximately 40%-50%.A novel idea is to use endoscopic vacuum therapy(EVT)in a preemptive setting to prevent anastomotic leakage and pancreatic fistulas.In a recent case series,EVT was proven to be effective in preventing leaks in patients with anastomotic ischemia.There have been no previous reports on preemptive EVT after pancreaticoduodenectomy.CASE SUMMARY We describe the case of a 71-year-old woman with hypertension and diabetes who was admitted to the emergency room with jaundice,choluria,fecal acholia,abdominal pain,and fever.Admission examinations revealed leukocytosis and hyperbilirubinemia(total:13 mg/dL;conjugated:12.1 mg/dL).Abdominal ultrasound showed cholelithiasis and dilation of the common bile duct.Magnetic resonance imaging demonstrated a stenotic area,and a biopsy confirmed cholangiocarcinoma. Considering the high risk of leaks after pancreaticoduodenectomy,preemptive endoluminal vacuum therapy was performed.The system comprised a nasogastric tube,gauze,and an antimicrobial incise drape.The negative pressure was 125 mmHg,and no adverse events occurred.The patient was discharged on postoperative day 5 without any symptoms.CONCLUSION Preemptive endoluminal vacuum therapy may be a safe and feasible technique to reduce leaks after pancreaticoduodenectomy. | Flaubert Sena de Medeiros Epifanio Silvino do Monte Junior Romero de Lima França Heli Clóvis de Medeiros Neto Juliany Medeiros Santos Eligio Alves Almeida Júnior Samuel Oliveira da Silva Júnior Mario Herman Santos Moura Pedreira Tavares Eduardo Guimarães Hourneaux de Moura | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，11： | 0 |
| 18 | Biomass-glycerol briquettes are not necessarily mechanically stable and energetically effective显示文摘The re-use of glycerol from biodiesel industry as an alternative lubricant for making high-performance briquettes is usual.However,the technical performance of this agro-industrial residue is not consistent.This study outlines,accordingly,the real risk of introducing glycerol into the co-briquetting of highly caloric by-products of energy-crops.The production of hybrid briquettes consisted of pressing mixtures of residues of sugarcane and sorghum with the liquid additive at 10,20,and 30 wt.%in bench-scale hydraulic piston presser machine.Irrespective of the blend,briquettes containing the supplement at the highest level as part of their composition ended up being much more hygroscopic(20.10%)and less energetic(3.15 GJ m^(−3)).The explanation for the negative impact of glycerol on the thermomechanical behavior of briquettes would be overconcen-tration of additive capable of effectively defying compacting biomass.The degree of compaction during co-briquetting has likely gone down quickly with a maximizing level of glycerol.As long as the additive is not able to lubricate the feedstock suitably,improbability of biomass particles to successfully bond together to form themselves into mechanically stable and energetically effective briquettes is large.Besides lower density(273.80 kg m^(−3))and higher relaxation(22.75%),briquettes with glycerol at 30 wt.%generally were aesthetically unpleasing.Practically,these products resisted no longer to handling,transportation,and storage.They lost their shape easily during emptying and shifting them,thus,releasing larger quanti-ties of biomass to the environment.Preliminary evidence of high-viscosity glycerol capable of limiting safe and effective production of high-performance briquettes for heating and power exists. | Bruno Rafael de Almeida Moreira Ronaldo da Silva Viana Samuel Dias Moreira Monique dos Santos Lima Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi | 2020 | Waste Disposal and Sustainable Energy2020，2，4： | 0 |
| 19 | Self-reported participation restrictions in normal hearing individuals in thyroid ontogeny: Evidence of subclinical changes显示文摘Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism patients.Methods: An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with(n = 42) and without(n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's ttest and chi-square test were used for statistical analysis at a significance level of 5%.Results: There was a significant(p < 0.001) self-reported participation restrictions in CH(61.9%), with a greater relevance for the social domain(p = 0.002). There was a greater frequency of mild/moderate(40.5%)and higher prevalence of association with clinical factors and adherence to treatment.Conclusion: The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population. | Caio Le?nidas Oliveira de Andrade Gabriela Carvalho Machado Luan Paulo Franco Magalh?es Elen Pereira de Jesus Elaine Alves Matias Taíse Lima de Oliveira Cerqueira Hélida Braga de Oliveira Luciene da Cruz Fernandes Helton Estrela Ramos Crésio de Arag?o Dantas Alves | 2019 | Journal of Otology2019，14，1： | 0 |
| 20 | Prevalence,phenotype and medication for the pediatric inflammatory bowel disease population of a state in Southeastern Brazil显示文摘BACKGROUND Inflammatory bowel disease(IBD)can lead to social and economic impacts worldwide.In Brazil,where its adult prevalence is increasing,the epidemiology of the pediatric population is not well known,although there is a documented increase in pediatric IBD incidence worldwide.Brazil has continental dimensions,and Espírito Santo is a state of southeastern Brazil,the region with the highest demographic densities and is the economically most important in the country.AIM To assess the prevalence,incidence,phenotype and medications in a Southeastern Brazilian pediatric population.METHODS Data were retrieved from the Public Medication-Dispensing System of the Department of Health in Espírito Santo state from documentation required to have access to highly expensive medication from August 1,2012 to July 31,2014.There were 1048 registered patients with IBD of all ages,and of these patients,the cases≤17 years were selected.The data were obtained through the analysis of administrative requests for these medications and included medical reports,endoscopy exams,histopathology and imaging tests,which followed the Clinical Protocols and Therapeutic Guidelines of the Brazilian Government.Only confirmed cases of IBD were included in the study.RESULTS There were 55 pediatric patients/1048 registered patients(5.34%),with Crohn's disease(CD)representing 30/55(55%),ulcerative colitis(UC)24/55(43.6%)and 1 unclassified IBD,a significant difference from adult patients(P=0.004).The prevalence of IBD in pediatric patients was 5.02 cases/100.000 inhabitants;the incidence in 2014 was 1.36 cases/100.000 inhabitants.The mean age at diagnosis was 12.2 years(±4.2).There were 7 children diagnosed up to 6 years old,7 between 7 to 10 years old and 41 between 11 and≤17 years old.There was no difference in the distribution of UC and CD between these age categories(P=0.743).There was no difference in gender distribution in relation to adults.Children and adolescents with UC had a predominance of pancolitis,unlike adults(P=0.001),and used aminosalicylates and immunomodulators for their treatment.Pediatric patients with CD did not present a difference in disease location but had a higher frequency of fistulizing behavior(P=0.03)and perianal disease phenotype(P=0.007)than adult patients.Patients with CD used more immunomodulators and biological therapy.Treatment with biological therapy was more frequently used in pediatric patients than in adults(P<0.001).CONCLUSION Although the data from this study demonstrate that incidence and prevalence rates are low in southeastern Brazil,these data demonstrate the severity of IBD in pediatric patients,with the need for early diagnosis and therapy,avoiding serious damage. | Adalberta Lima Martins Renata de SáBrito Fróes Maria da Penha Zago-Gomes | 2022 | World Journal of Clinical Pediatrics2022，11，4： | 0 |
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