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| 1 | How important is donor age in liver transplantation?显示文摘The age of liver donors has been increasing in the past several years because of a donor shortage. In the United States, 33% of donors are age 50 years or older, as are more than 50% in some European countries. The impact of donor age on liver transplantation(LT) has been analyzed in several studies with contradictory conclusions. Nevertheless, recent analyses of the largest databases demonstrate that having an older donor is a risk factor for graft failure. Donor age is included as a risk factor in the more relevant graft survival scores, such as the Donor Risk Index, donor age and Model for End-stage Liver Disease, Survival Outcomes Following Liver Transplantation, and the Balance of Risk. The use of old donors is related to an increased rate of biliary complications and hepatitis C virus-related graft failure. Although liver function does not seem to be significantly affected by age, the incidence of several liver diseases increases with age, and the capacity of the liver to manage or overcome liver diseases or external injuries decreases. In this paper, the importance of age in LT outcomes, the role of donor age as a risk factor, and the influence of aging on liver regeneration are reviewed. | Alberto Lué Estela Solanas Pedro Baptista Sara Lorente Juan J Araiz Agustin Garcia-Gil M Trinidad Serrano | 2016 | World Journal of Gastroenterology2016，22，21： | 10 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Differences in the pheno- lic composition and sensory profile between red wines aged in oak barrels and wines aged with oak chips显示文摘 | Miriam O H Silvia P M Estela C M | 2010 | LWT-Food Science and Technology2010，，43： | 1 |
| 4 | Different enzyme requirments for the synthesis of biodiesel Novazym 435 and Lipozyme TL IM显示文摘 | ESTELA H M CRISTINA O | 2008 | Bioresource Techno2008，99，2： | 1 |
| 5 | Enzymatic re - esterification of lower glycerides from soybean oil with conjugated linole- ic acid (CLA) 显示文摘 | ESTELA H M CRISTINA O | 2009 | J Agric Food Ehem2009，57，： | 1 |
| 6 | Molecular and insecticidal characterization of a Cry1I protein toxic to insects of the families noctuidae,tortricidae,plutellidae,and chrysomelidae显示文摘 | Ruiz De Escudero I Estela A Porcar M | 2006 | Applied and Environmental Microbiology2006，72，7： | 1 |
| 7 | Effects of heavy metals on microbial activity of water and sediment communities 显示文摘 | Cristina R M Mercedes G E Estela B D | 1999 | Water Air&Soil Pollution1999，15，2： | 1 |
| 8 | Simultaneous determination of fluorophores with overlapped spectra by sequential injection analysis coupled to variable angle scanning fluorescence spectrometry and multivariate linear regression algorithms显示文摘 | Armas G Miro M Estela J M | 2002 | Anal Chim Acta2002，471，2： | 1 |
| 9 | Sequential fractionation and plant availability of heavy metals as affected by sewage sludge applications to soil显示文摘 | Canet Pomares R F Estela M | 1998 | Communications in Soil Science and Plant Analysis1998，29，56： | 1 |
| 10 | Antioxidant and cytotoxic activities of canadine: Biological effects and structural aspects显示文摘 | Estela R. Correché Sebastian A. Andujar Rita R. Kurdelas María J. Gómez Lechón Mónica L. Freile Ricardo D. Enriz | 2008 | Bioorganic & Medicinal Chemistry2008，，7： | 1 |
| 11 | Flow analysis techniques for phosphorus: an overview显示文摘 | ESTELA J M CERDA V | 2005 | Talanta2005，66，： | 1 |
| 12 | Flow-through solid-phase reflectometric method for simultaneous multiresidue determination of nitrophenol derivatives 显示文摘 | MANERA M MIRO M ESTELA J M | 2007 | Anal Chim Acta2007，582，1： | 1 |
| 13 | Flow analysis techniques for phos- phorus:An overview显示文摘 | ESTELA J M CERDA V | 2005 | Talanta2005，66，2： | 1 |
| 14 | Short-term oral toxicity of quercetin and pterostibene in Swiss mice显示文摘 | Ruiz M J Femamdez M Estela J M | 2006 | Toxicol Lett2006，1641，： | 1 |
| 15 | Improving the chemilum inescence-based determination of sulphide in complex environmental samples by using a new,automated multi-syringe flow inject ion analysis sy stem coupled to a g as diffusion unit显示文摘 | Maya F Estela J M Cerda V | | 0，，1： | 1 |
| 16 | Molecular and insecticidal characterization of a Cry1I protein toxic to insects of the families Noctuidae,Tortricidae,Plutellidae and Chrysomelidae显示文摘 | Escudero I R Estela A Porcar M | 2006 | Applied and Environmental Microbiology2006，72，7： | 1 |
| 17 | Survival and prognostic factors for AIDS and non-AIDS patients with Non-Hodgkin' s lymphoma in Bahia, Brazih A retrospective cohort study显示文摘 | Estela L Marinho M Ivana L | 2013 | ISRN Hematology2013，7，： | 1 |
| 18 | Flow analysis techniques for phosphorus : An overview 显示文摘 | Estela J M Cerda V | 2005 | Talanta2005，66，： | 1 |
| 19 | Software applied to oral implantology: Update 显示文摘 | Serrano M R Estela S A Diago M P | 2008 | Med Oral Patol Oral Cir Bucal2008，13，10： | 1 |
| 20 | Growth and siderophore production of Xy-lella fastidiosa under iron - limited conditions 显示文摘 | Estela Silva - Stenico M Pacheco F T H Rodrigues JL M | 2005 | Mi-crobiological research2005，，4： | 1 |
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