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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Celecoxib enhances the detoxification of diethylnitrosamine in rat liver cancer显示文摘AIM:To study the effect of celecoxib(CXB) on diethylnitrosamine activation through the regulation of cytochrome P450 in a hepatocarcinogenesis model.METHODS:Six-week-old male Sprague-Dawley rats were randomly divided into fi ve groups,a non-treated group(NT) ,a diethylnitrosamine-treated group(DEN) ,a DEN+CXB-treated group(DEN+CXB) ,and CXB 8 d-treated and CXB 32 d-treated groups.The effects of celecoxib on the enzymatic activities of CYP1A1,2A,2B1/2,and 2E1 were assessed in hepatic microsomes 24 h after DEN administration.Changes in CYP1A1 and CYP2B1/2 protein expression were also evaluated.The rate of DEN metabolism was measured by the production of the deethylation metabolite acetaldehyde,and the denitrosation metabolite nitrite.RESULTS:DEN+CXB administration produced a significant increase in the enzymatic activities of CYP2B1/2 and 1A1,whereas it did not change the activities of CYP2A and 2E1,compared to that of the DEN group.CXB treatment for eight days did not produce a signif icant effect on enzymatic activity when compared to the NT group;however,when it was administered for prolonged times(CXB 32 d group) ,the enzymatic activities were increased in a similar pattern to those in the DEN+CXB group.The observed increase in the enzymatic activities in the DEN+CXB group was accompanied by an increase in the CYP2B1/2 protein levels;no changes were observed in the levels of CYP1A1.In vitro,CXB increased the denitrosation of DEN,a pathway of metabolic detoxification.The addition of SKF-525A,a preferential inhibitor of CYP2B,abrogated the denitrosation of DEN.CONCLUSION:These results suggest that the mechanism of action of CXB involves enhancement of the detoxif ication of DEN by an increasing denitrosation via CYP2B1/2. | Martha Estela Salcido-Neyoy Adolfo Sierra-Santoyo Olga Beltrán-Ramírez José Roberto Macías-Pérez Saúl Villa-Trevio | 2009 | World Journal of Gastroenterology2009，15，19： | 3 |
| 3 | Vitamin B12-induced spermatogenesis recovery in cimetidine-treated rats: effect on the spermatogonia number and sperm concentration显示文摘H 2-receptor 对手 cimetidine 是也由于它的 antiangiogenic 效果为癌症的治疗使用的 antiulcer 药。然而,这药在生精的小管引起了结构的变化。维生素 B 12 为男不孕的治疗被用作一个治疗学的代理人。有维生素 B 12 的老鼠的补充在 cimetidine 治疗期间恢复了损坏生精的小管,但是这维生素怎么恢复生精的上皮,没被澄清。在这研究,我们评估了维生素 B 12 是否在对待 cimetidine 的老鼠改进 spermatogonia, spermatocytes,和精子集中的数字。成年雄的老鼠如下被对待 50 天:cimetidine 组收到了 cimetidine 的 100 mg kg 1 b.w, cimetidine-B 12 组收到了 cimetidine 和 12 组收到了的维生素 B 12-hydroxocobalamin, B 的 3 g 仅仅维生素的 3 g,和控制组收到了盐。精子集中被计算,嵌入 historesin 的睾丸节被用于 spermatogonia 的量的分析(一;In/B ) 并且 spermatocytes。TUNEL 方法和 PCNA immunofluorescence 被执行。Cimetidine 在精子集中引起了重要减小。TUNEL 积极的 spermatogonia 和 spermatocytes 在这些房间的数字被相关到重要减小。在 cimetidine-B 12 组,精子集中比在 spermatogonia (阶段 II-VI ) 的数字的 cimetidine 组和重要增加被相关到 PCNA-immunolabeled spermatogonia 和 spermatocytes 的高发生的高。结果证明有维生素 B 12 的老鼠的补充在 cimetidine 处理期间增加精子集中并且在 spermatogonia 和 spermatocytes 的恢复施加潜在的效果。 | Flavia L Beltrame Estela Sasso-Cerri | 2017 | Asian Journal of Andrology2017，19，5： | 1 |
| 4 | Effects of a dust deposition event on coastal marine microbial abundance and activity, bacterial community structure and ecosystem function 显示文摘 | Itziar L Thomas L Estela R | 2010 | Journal of Plankton Research2010，32，4： | 1 |
| 5 | Survival and prognostic factors for AIDS and non-AIDS patients with Non-Hodgkin' s lymphoma in Bahia, Brazih A retrospective cohort study显示文摘 | Estela L Marinho M Ivana L | 2013 | ISRN Hematology2013，7，： | 1 |
| 6 | Contrast-enhanced ultrasound in the staging of acute pancreatitis显示文摘 | Tomás Ripollés María J Martínez Estela López Inmaculada Castelló Fructuoso Delgado | 2010 | European Radiology2010，，10： | 1 |
| 7 | The foliar fungal endophytes of Citrus limon in Argentina显示文摘 | Durán L Daniel Ploper | 2005 | Canadian Journal of Botany2005，83，4： | 1 |
| 8 | Water imbibing capacity of soy protein isolate:influence of protein denaturation显示文摘 | Delia A S Jorge R W Estela L A | 2001 | Journal of Agricultural and Food Chemistry2001，39，： | 1 |
| 9 | Separation of di-n-propyl ether and n-propyl alcohol by extractive distillation and pressure-swing distillation: Computer simulation and economic optimization显示文摘 | Estela L Juan B M Macruz B | 2011 | Chemical Engineering and Processing2011，50，11： | 1 |
| 10 | Electrophoretic solubility and functional properties of commercial soy protein isolates 显示文摘 | Arrese Estela L Sorgentini Delia A Wagner Jorge R | 1991 | J Agric Food Chem1991，39，： | 1 |
| 11 | Erosion in Mediterranean landscapes:Changes and future challenges显示文摘 | Josd M G Estela N R Noemi L R | 2013 | Geomorphology2013，，198： | 1 |
| 12 | 2010,Effects of a dust deposition event on coastal marine microbial abundance and activity, bacterial community structure and ecosystem function 显示文摘 | LEKUNBERRI I THOMAS L ESTELA R | 2010 | Journal of Plankton Research2010，32，4： | 1 |
| 13 | Polycystic ovary syndrome in Salvador, Brazil: a prevalence study in primary health- care 显示文摘 | Gabrielli L Estela ML | 2012 | Reproductive Biology and Endocrinology2012，10，： | 1 |
| 14 | Liver histological changes and lipid peroxidation in the amphibian Ambystoma mexicanum induced by sediment elutriates from the Lake Xochimilco显示文摘Lacustrine sediments accumulate pollutants that input from the lake watershed and can be released to the water column by sediment resuspension; thus, pollutants can change their bioavailability and exert adverse effects to aquatic biota. Shallow-urban lakes are particularly susceptible to receive pollutants from urban discharges and sediment resuspension. Lake Xochimilco, in Mexico City, an urban-shallow lake, faces multiple problems: urban sprawl, overexploitation of aquifers, drying of springs, discharge of wastewater from treatment plants, and sediment resuspension. The aquatic biota living in this ecosystem is continuously exposed to the release of pollutants from the sediments. We assessed the risk that pollutants released from sediments from Lake Xochimilco, Touristic(TZ) and Agriculture zone(AZ), can exert on a native amphibian species of the lake(Ambystoma mexicanum) through exposure bioassays to sediment elutriates. We evaluate alterations in the amphibian by three approaches: biochemical(level of lipid peroxidation,LPO), cellular(ultrastructure) and the liver histology of A. mexicanum and we compare them with a batch control. Additionally, we assessed heavy metals(Pb, Cd and Hg) in elutriates.Elutriates from TZ showed the highest concentrations of the metals assessed. Organisms exposed to sediment elutriates from either study sites showed higher LPO values than control organisms(p < 0.05). Organisms exposed to elutriates from the TZ showed the most conspicuous damages: hepatic vasodilation of sinusoids, capillaries with erythrocytes,leukocyte infiltration and cytoplasmic vacuolation in hepatocytes. The biological responses assessed reflected the risk that faces A. mexicanum when is exposed for prolonged periods to sediment resuspension in Lake Xochimilco. | Esperanza Ortiz-Ordonez Eugenia López-López Jacinto Elías Sedeno-Díaz Esther Uría Ignacio Andrés Morales María Estela Pérez Mineko Shibayama | 2016 | Journal of Environmental Sciences2016，28，8： | 0 |
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