|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver dysfunction and SARS-CoV-2 infection显示文摘Severe acute respiratory syndrome coronavirus 2 infection is the cause of coronavirus disease 2019(COVID-19),which predominantly affects the respiratory system;it also causes systemic and multi-organic disease.Liver damage is among the main extrapulmonary manifestations.COVID-19-associated liver injury is defined as any liver damage occurring during the disease course and treatment of COVID-19 in patients with or without pre-existing liver disease,and occurs in approximately one in five patients.Abnormal liver test results have been associated with a more severe course of COVID-19 and other complications,including death.Mechanisms linking COVID-19 to liver injury are diverse.Particular consideration should be made for patients with pre-existing liver disease,such as metabolic dysfunction-associated fatty liver disease,chronic liver disease due to viral or autoimmune disease,liver transplant carriers,or cirrhosis,given the risk for more severe outcomes.This manuscript summarizes the current lines of evidence on COVID-19-associated liver injury regarding pathophysiology,clinical significance,and management in both patients with or without preexisting liver disease,to facilitate clinicians’access to updated information and patient care.Finally,we mention the ideas and recommendations to be considered for future research. | Abraham Edgar Gracia-Ramos Joel Omar Jaquez-Quintana Raúl Contreras-Omaña Moises Auron | 2021 | World Journal of Gastroenterology2021，27，26： | 2 |
| 2 | 14-day triple, 5-day concomitant, and 10-day sequential therapies for Helicobacter pylori infection in seven Latin American sites: a randomised trial显示文摘 | E Robert Greenberg Garnet L Anderson Douglas R Morgan Javier Torres William D Chey Luis Eduardo Bravo Ricardo L Dominguez Catterina Ferreccio Rolando Herrero Eduardo C Lazcano-Ponce María Mercedes Meza-Montenegro Rodolfo Pe?a Edgar M Pe?a Eduardo Salazar- | 2011 | The Lancet2011，，9790： | 2 |
| 3 | Diatom Locomotion: A Consideration of Movement in Highly Viscous Situation显示文摘 | EDGAR L A | 1982 | British PhyoAlogioal Journal1982，17，3： | 1 |
| 4 | HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium显示文摘BACKGROUND The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence factor.AIM To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) cells.METHODS Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GLYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional modeling.RESULTS HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium cells.Immunogold technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS cells.Bioinformatics analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein to the external environment. The programs also showed a similarity with the Tip-alpha protein of H. pylori. Tip-alpha is an exotoxin that penetrates cells and induces tumor necrosis factor alpha production, and HP0953 could have a similar function as posttranslational modification sites were found;modifications in turn require enzymes located in eukaryotic cells. Thus, to be functional, HP0953 may necessarily need to be translocated inside the cell where it can trigger different mechanisms producing cellular damage.CONCLUSION The location of HP0953 around infected cells, the probable posttranslational modifications, and its similarity to an exotoxin suggest that this protein is a virulence factor. | Nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma L Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo Sandra Mendoza-Elizalde Edgar O López-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-López Marcela Salazar García Norma Velázquez-Guadarrama | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 5 | Two-photon Fluorescence and Second Harmonic Generation Phenomena in the Ordered Tissue 显示文摘 | ASATURR A L EDGAR A J | 2002 | Proceedings of SPIE2002，4633，： | 1 |
| 6 | Nitric oxide synthase and hypertension显示文摘 | Baudouin L Edgar A Leopoldo R | 2002 | Curr Opin Nephrol Hypertens2002，11，2： | 1 |
| 7 | How size is controlled:from Hippos to Yor- kies显示文摘 | BUTITITA L A EDGAR B A | 2007 | Nat Cell Biol2007，9，11： | 1 |
| 8 | Wingless and Notch regulate cell cycle arrest in the developing Drosophila wing显示文摘 | JOHOSTON L A EDGAR B A | 1998 | Nature1998，394，： | 1 |
| 9 | Filling out the Hippo pathway显示文摘 | Saucedo L J Edgar B A | 2007 | Nat Rev Mol Cell Biol2007，8，8： | 1 |
| 10 | Comparison of mortality in all patients on dialysis, patients on dialysis awaiting Transplantation, and Recipients of a first cadaveric transplant显示文摘 | ROBERT A W VALARIE B A EDGAR L M | 1999 | N Eng J Med1999，341，23： | 1 |
| 11 | Gene-Expression Pro- filing of Human Osteoblasts Following Treatment with the Ionic Products of Bioglass 45 $5 Dissolution 显示文摘 | Xynos I D Edgar A J Buttery L D | 2001 | J Biomed Mater Res2001，55，2： | 1 |
| 12 | Simultaneous heat and masstransfer in free convection 显示文摘 | Mathers W Madden A Edgar L | 1957 | Industrial and Engineering Chemistry1957，49，6： | 1 |
| 13 | Geneexpression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution 显示文摘 | Xynos I D Edgar A J Buttery L D | 2001 | J Biomed Mater Res2001，55，： | 1 |
| 14 | Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition 显示文摘 | EDGAR K A CROCKER L CHENG E | 2014 | Genes Cancer2014，5，34： | 1 |
| 15 | Diatom locomotion: Computer assisted analysis of cine film 显示文摘 | Edgar L A | 1979 | British Phycological Journal1979，14，1： | 1 |
| 16 | Diatom locomotion: A consideration of movement in a highly viscous situation 显示文摘 | Edgar L A | 1982 | British Phycological Journal1982，17，3： | 1 |
| 17 | Mucilage secretions of moving diatoms显示文摘 | Edgar L A | 1983 | Protoplasma1983，118，1： | 1 |
| 18 | CXCR4 physically associates with the T cell receptor to signal in T cells显示文摘 | Kumar A Humphreys T D Kremer K N Bramati P S Brad- field L Edgar C E | 2006 | Immunity2006，25，： | 1 |
| 19 | The catalysis of biodiesel synthesis显示文摘 | Edgar L James G G David A B | 2006 | Catalysis2006，，19： | 1 |
| 20 | Serotyping of Campylobacter jejuni by slide agglutination based on heat-labile antigenic factors显示文摘 | Lior H Woodward D L Edgar J A | 1982 | J Clin Microbiol1982，15，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员