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| 1 | Favorable lifestyle before diagnosis associated with lower risk of screen-detected advanced colorectal neoplasia显示文摘AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia(ACN) in colorectal cancer(CRC) screening.METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero(poorest) to six(best). Odds ratios(ORs) and 95%CIs were calculated using multivariable logistic regression to evaluate the association between the single lifestyle variables and the lifestyle score and the probability of detecting ACN.RESULTS: In all 6315 women and men completed the lifestyle questionnaire, 3323(53%) in the FIT arm and 2992(47%) in the FS arm. This was 89% of those who participated in screening. ACN was diagnosed in 311(5%) participants of which 25(8%) were diagnosed with CRC. For individuals with a lifestyle score of two, three, four, and five-six, the ORs(95%CI) for the probability of ACN detection were 0.82(0.45-1.16), 0.43(0.28-0.73), 0.41(0.23-0.64), and 0.41(0.22-0.73), respectively compared to individuals with a lifestyle score of zero-one. Of the single lifestyle factors, adherence to non-smoking and moderate alcohol intake were associated with a decreased probability of ACN detection compared to being a smoker or having a high alcohol intake 0.53(0.42-0.68) and 0.63(0.43-0.93) respectively.CONCLUSION: Adopted healthy behaviors were inversely associated with the probability of ACN detection. Lifestyle assessment might be useful for risk stratification in CRC screening. | Markus D Knudsen Thomas de Lange Edoardo Botteri Dung-Hong Nguyen Helge Evensen Chloé B Steen Geir Hoff Tomm Bernklev Anette Hjartaker Paula Berstad | 2016 | World Journal of Gastroenterology2016，22，27： | 3 |
| 2 | Psychological effects of colorectal cancer screening: Participants vs individuals not invited显示文摘AIM To investigate the possible long-term psychological harm of participating in colorectal cancer(CRC)screening in Norway.METHODS In a prospective, randomized trial, 14294 participants(aged 50-74 years) were invited to either flexible sigmoidoscopy(FS) screening, or a faecal immunochemical test(FIT)(1:1). In total, 4422 screening participants(32%) completed the questionnaire, which consisted of the Hospital Anxiety and Depression Scale and the SF-12, a generic health-related quality of life(HRQOL) measurement, when invited to screening and one year after the invitation. A control group of 7650 individuals was invited to complete the questionnaire only, at baseline and one year after, and 1911(25%) completed the questionnaires.RESULTS Receiving a positive or negative screening result and participating in the two different screening modalities did not cause clinically relevant mean changes in anxiety, depression or HRQOL after one year. FS screening, but not FIT, was associated with an increased probability of being an anxiety case(score ≥ 8) at the one-year follow-up(5.6% of FS participants transitioned from being not anxious to anxious, while 3.0% experienced the reverse). This increase was moderately significantly different from the changes in the control group(in which the corresponding numbers were 4.8% and 4.5%, respectively), P = 0.06. CONCLUSION Most individuals do not experience psychological effects of CRC screening participation after one year, while FS participation is associated with increased anxiety for a smaller group. | Benedicte Kirk?en Paula Berstad Edoardo Botteri Linn Bernklev Badboni El-Safadi Geir Hoff Thomas de Lange Tomm Bernklev | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 3 | Cigarette Smoking and Adenomatous Polyps: A Meta-analysis显示文摘 | Edoardo Botteri Simona Iodice Sara Raimondi Patrick Maisonneuve Albert B. Lowenfels | 2008 | Gastroenterology2008，，2： | 1 |
| 4 | Changes in Circulating Tumor Cell Detection in Patients with Localized Breast Cancer Before and After Surgery显示文摘 | Maria T. Sandri MD Laura Zorzino DSc Maria C. Cassatella DSc Fabio Bassi MD Alberto Luini MD Chiara Casadio MD Edoardo Botteri PhD Nicole Rotmensz PhD Laura Adamoli PhD Franco Nolè MD | 2010 | Annals of Surgical Oncology2010，，6： | 1 |
| 5 | ABO blood group and cancer显示文摘 | Simona Iodice Patrick Maisonneuve Edoardo Botteri Maria Teresa Sandri Albert B. Lowenfels | 2010 | European Journal of Cancer2010，，18： | 1 |
| 6 | Prognostic value of human papillomavirus in anal squamous cell carcinoma显示文摘 | Paola Simona Ravenda Elena Magni Edoardo Botteri Michela Manzotti Massimo Barberis Davide Vacirca Cristina Maria Trovato Veronica Dell’Acqua Maria Cristina Leonardi Mario Sideri Nicola Fazio Maria Giulia Zampino | 2014 | Cancer Chemotherapy and Pharmacology2014，，5： | 1 |
| 7 | Peptide receptor radionuclide therapy with 90Y-DOTATOC in recurrent meningioma显示文摘 | Mirco Bartolomei Lisa Bodei Concetta Cicco Chiara Maria Grana Marta Cremonesi Edoardo Botteri Silvia Melania Baio Demetrio Aricò Maddalena Sansovini Giovanni Paganelli | 2009 | European Journal of Nuclear Medicine and Molecular Imaging2009，，9： | 1 |
| 8 | ABO blood group and cancer显示文摘 | Simona Iodice Patrick Maisonneuve Edoardo Botteri Maria Teresa Sandri Albert B. Lowenfels | 2010 | European Journal of Cancer2010，，18： | 1 |
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