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| 1 | Effects of protein deprivation and re-feeding on P2X_2 receptors in enteric neurons显示文摘AIM:To investigate the effects of malnutrition and refeeding on the P2X2 receptor,nitric oxide synthase(NOS),calretinin,calbindin and choline acetyltransferase(ChAT) in neurons of the rat ileum.METHODS:We analyzed the co-localization,numbers and sizes of P2X2-expressing neurons in relation to NOS-immunoreactive(IR),calbindin-IR,ChAT-IR,and calretinin-IR neurons of the myenteric and submucosal plexus.The experimental groups consisted of:(1) rats maintained on normal feed throughout pregnancy until 42 d post-parturition(N);(2) rats deprived of protein throughout pregnancy and 42 d post-parturition(D);and(3) rats undernourished for 21 d post-parturition and then given a protein diet from days 22 to 42(DR).The myenteric and submucosal plexuses were evaluated by double labeling by immunohistochemical methods for P2X2 receptor,NOS,ChAT,calbindin and calretinin.RESULTS:We found similar P2X2 receptor immunoreactivity in the cytoplasm and surface membranes of myenteric and submucosal neurons from the N,D and DR groups.Double labeling of the myenteric plexus demonstrated that approximately 100% of NOS-IR,calbindin-IR,calretinin-IR and ChAT-IR neurons in all groups also expressed the P2X2 receptor.In the submucosal plexus,the calretinin-IR,ChAT-IR and calbindin-IR neurons were nearly all immunoreactive for the P2X2 receptor.In the myenteric plexus,there was a 19% increase in numbers per cm2 for P2X2 receptor-IR neurons,64% for NOS-IR,84% for calretinin-IR and 26% for ChAT-IR neurons in the D group.The spatial density of calbindin-IR neurons,however,did not differ among the three groups.The submucosal neuronal density increased for calbindin-IR,calretinin-IR and ChAT-IR neurons.The average size of neurons in the myenteric plexus neurons in the D group was less than that in the controls and,in the re-fed rats;there was a 34% reduction in size only for the calretinin-IR neurons.CONCLUSION:This work demonstrates that expression of the P2X2 receptor is present in inhibitory,intrinsic primary afferent,cholinergic secretomotor and vasomotor neurons.Undernutrition affected P2X2 receptor expression in the submucosal plexus,and neuronal and size.These changes were rescued in the re-fed rats. | Rúbia Misawa Priscila Azevedo Girotti Márcia Sanae Mizuno Edson Aparecido Liberti John Barton Furness Patricia Castelucci | 2010 | World Journal of Gastroenterology2010，16，29： | 2 |
| 2 | The multiple-liga- ment injured knee: Evaluation,treatment,and results显示文摘 | FANELLI G C ORCUTT D R EDSON C J | 2005 | Arthro- scopy2005，21，4： | 1 |
| 3 | Disseminated Mycobacterium abscessus infection manifesting as fever of unknown origin and intra-abdominal lymphadenitis:case report and literature review显示文摘 | Mueller P S Edson R S | 2001 | Diagn Microbiol Infect Dis2001，39，1： | 1 |
| 4 | A new guaiane mannoside from a Eutypa-like fungus isolated from Murraya paniculata in Brazil 显示文摘 | AFONSO D L EDSON R F SOUZA A Q L | 2008 | J Braz Chem Soc2008，19，7： | 1 |
| 5 | Electromagnetic Stimulation Combined with Aloe vera Increases Collagen Reorganization in Burn Repair显示文摘 | Sofia Poletti Leticia D. Lucke Fernanda O Bortolazzo Renata M. Acunha Marcos G. Mattos Femanda OG. Gaspi Thiago A. M. Andrade Maria Esmeria C. Amaral Andrea A .Aro Edson R Pimentel Marcelo AM. Esquisatto Fernanda A. S. Mendonga Glaucia M. T. Santos | 2018 | Journal of Pharmacy and Pharmacology2018，6，7： | 1 |
| 6 | Venom apparatus of braconid wasps:comparative ultrastructure of reservoirs and gland fila-ments显示文摘 | EDSON K M BARLIN M R VINSON S B | 1982 | Toxicon1982，20，3： | 1 |
| 7 | Textile sludge applica-tion to non-productive soil:Physico-chemical and phytotoxicity aspects 显示文摘 | Edson V C R Luciana M Maria M S | 2007 | Ecotoxicology and Environmental Safety2007，65，1： | 1 |
| 8 | Biomass growth, micronucleus induction,and antioxidant stress enzyme responses in VICIA FABA exposed to cadmium in solution显示文摘 | Edson V Cordova R Cleidson V | 2003 | Environmental Toxicology and Chemistry2003，22，3： | 1 |
| 9 | Direct covariance airsea CO2fluxes显示文摘 | McGillis W R Edson J B Hare J E | 2001 | Journal of Geophysical Research2001，106，16： | 1 |
| 10 | Production of hydrogen via steam reforming of biofuels on Ni/CeO 2-Al 2 O 3 catalysts promoted by noble metals显示文摘 | Profeti Luciene P R Ticianelli Edson A Assaf Elisabete M | 2009 | International Journal of Hydrogen Energy2009，34，： | 1 |
| 11 | Peck polarization properties of corner reflectors and cavities显示文摘 | Edson R | 1962 | J Opt Soc Am1962，52，3： | 1 |
| 12 | Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development显示文摘 | Edson M A Nalam R L Clementi C | 2010 | Mol Endo- crinol2010，24，6： | 1 |
| 13 | Simultane- ous preconcentration of copper, zinc, cadmium, and nickel in water samples by cloud point extraction u- sing 4-(2-pyridylazo)-resorcinol and their determina- tion by inductively coupled plasma optic emission spectrometry显示文摘 | Edson L S Paulo dos S R Maria F G | 2009 | Journal of Hazardous Materials2009，171，： | 1 |
| 14 | Bet tman Selfconstrualreference groups,and brand meaning显示文摘 | Escalas Jennifer Edson James R | | 0，，03： | 1 |
| 15 | The use of curtius rearrangement in the synthesis of 4-aminothiazolidines 显示文摘 | MaraE F B Hugo S B Edson R C | 1999 | Synthesis1999，6，： | 1 |
| 16 | Rhinoscleroma: a growing concern in the United States? Mayo Clinic experience 显示文摘 | Andraca R Edson RS Kern EB | 1993 | Mayo Clin Proc1993，68，： | 1 |
| 17 | Analysis and functionaL annotation of an expressed sequence tag collection for tropical crop sugarcane显示文摘 | ANDPE L V FELIPE R S EDSON L K et at | 2003 | Genome Res2003，13，： | 1 |
| 18 | The aminoglycosidesstreptomycin, kanamycin, gentamicin, tobramycin, amikacin, netilmicin, sisomicin显示文摘 | EDSON R S KEYS T F | 1983 | Mayo Clinic Proceedings1983，58，2： | 1 |
| 19 | Synthesis and characterization of lead zirconate titanate powders obtained by the oxidant peroxo method显示文摘 | EMERSON R C EDSON R L ELSON L | 2009 | J Alloy Compd2009，469，12： | 1 |
| 20 | Eucalyptus ESTsinvolved in mechanisms against plant pathogens and environmen-tal stresses显示文摘 | Daniel D R Edson L F Leonardo P B | 2010 | Summa Phytopathol2010，36，4： | 1 |
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